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报告题目:From Transcriptional Regulation to Fungal Natural Product

报告人:尹文兵 研究员

主持人:戴均贵 研究员






尹文兵,研究员,博士生导师。于2009年毕业于德国马尔堡大学,获得博士学位。先后在美国威斯康辛大学麦迪逊分校、美国加州大学洛杉矶分校做博士后研究工作。2014年初正式回国工作并入选中科院百人计划。在J. Am. Chem. Soc.J. Biol. Chem.Mol. Microbiol.ACS Synth.Biol. ChembiochemOrg. Biomol. Chem.Nature Chem. Biol.等国际著名刊物发表论文近20篇。由于出色的学术成绩,获得2008年度国家优秀自费留学生奖学金。当前是美国化学学会的会员和Fungal Genetics and Biology杂志的特邀客座编辑。



The fungal kingdom is remarkable for the production of bioactive natural products commonly referred to as secondary metabolites (SMs). The study of fungal secondary metabolism has recently garnered significant interest, and the advent of fungal genomics has led to new insights into SM discovery and regulatory mechanisms. Much of this activity is driven by interests in drug discovery due to the biological properties of these metabolites. However, the treasure of SM is far underestimated and unexplored from the sequenced genomes because most of the biosynthetic genes are silent in the laboratory conditions. Here we describe key technological breakthroughs that together result in advances in mining the fungal SMs.  These include: (1) we identified a series of SM restorers and novel metabolites by manipulating global regulator LaeA; (2) prenyltransferase-guided discovery of fungal indole alkaloid and (3) novel polyketide production in a heterologous expression via synthetic biological approaches. Taken together, our studies provide the efficient ways for finding new SM regulators and bioactive metabolites.