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研究员

胡宽

职 称:助理教授

所属科室:天然药物活性物质与功能国家重点实验室

导师类别:博士生导师

联系方式:hukuan@imm.ac.cn

所属重点实验室:天然药物活性物质与功能国家重点实验室

个人简介

胡宽,国家海外高层次青年人才,北京市“科技新星”。迄今已在国际著名学术刊物上发表高水平 SCI 论文 70 余篇,其中以第一作者/通讯作者(含共同)身份发表40余篇论文,包括 Nat. Commun.、 Sci. Adv.、 Agnew. Chem. Int. Ed.、J. Immunother. Cancer、Nano Energy、Nano Today、Acta Pharm. Sin. B、Small、CCS Chem.、Bioactive Mater.、Adv. Drug Deliver. Rev.、Coordin. Chem. Rev.等。获得授权发明专利 9 项;撰写中英文专著共 2 本。开发的两个多肽诊断类核药已经进入临床阶段。兼任 Front. Chem.、 JoVE、 Materials 等 SCI 期刊的客座编辑,兼任中国生物工程学会青年委员。主持国家、省市、院校各级项目课题多项。曾获日本高度人才称号、 WILEY JLCR 青年科学家奖、日本核医学会研究奖励赏、中美核医学与分子影像协会青年科学家奖、美国核医学会年会最佳海外摘要奖等荣誉 10 余项。

研究方向

以解决临床重大用药需求为目标开展创新药物相关的研究。
1、 以攻克威胁人类健康的重大疾病(如恶性肿瘤、心脑血管疾病)为导向,开发具有临床诊断和治疗价值的多肽核素偶联药物和BNCT靶向药物;
2、 结合化学合成和基因工程方法,发展高通量筛选先导活性多肽方法;
3、 开发温和高效的生物正交方法,用于多肽、蛋白等生物大分子的核素选择性标记, 并进行临床评价。

发表论文

1)Duo Wang#, Chan Feng#, Zeyu Xiao#,*, Cuiqing Huang, Zerong Chen, Weiming Fang, Xiaocong Ma, Xingkai Wang, Liangping Luo*, Kuan Hu*, Wei Tao*. Therapeutic hydrogel for enhanced immunotherapy: A powerful combination of MnO2 nanosheets and vascular disruption. Nano Today, in pression, (2022).
2) Dongyuan Wang*, Yuan Tian, Yu Zhang, Xiaona Sun, Yuxuan Wu, Ruping Liu, Fang Zeng, Jingjing Du & Kuan Hu*. An assembly-inducing PDC enabling the efficient nuclear delivery of nucleic acid for cancer stem-like cell suppression. Nanoscale, 14, 15384-15392, (2022).
3) Juan Sun#, Zhenyuan Huangfu#, Jiangtao Yang, Guanglin Wang*, Kuan Hu*, Mingyuan Gao & Zhiyuan Zhong*. Imaging-guided targeted radionuclide tumor therapy: From concept to clinical translation. Advanced Drug Delivery Reviews 190, 114538, (2022).
4) Zeyu Xiao#, Duo Wang#, Chan Wang#, Zerong Chen, Cuiqing Huang, Yuan Yang, Lin Xie, Lulu Zhang, Lingling Xu, Ming-Rong Zhang*, Kuan Hu*, Zhou Li* & Liangping Luo*. PEIGel: A biocompatible and injectable scaffold with innate immune adjuvanticity for synergized local immunotherapy. Materials Today Bio, 100297, (2022).
5) Lingling Zhang#, Kuan Hu#, Tuo Shao, Lu Hou, Shaojuan Zhang, Weijian Ye, Lee Josephson, Jeffrey H. Meyer, Ming-Rong Zhang, Neil Vasdev, Jinghao Wang, Hao Xu, Lu Wang* & Steven H. Liang*. Recent developments on PET radiotracers for TSPO and their applications in neuroimaging. Acta Pharmaceutica Sinica B 11, 373-393, (2021).
6) Lin Xie#, Kuan Hu#, Yanhong Duo#, Takashi Shimokawa, Katsushi Kumata, Yiding Zhang, Cuiping Jiang, Lulu Zhang, Nobuki Nengaki, Hidekatsu Wakizaka, Yihai Cao* & Ming-Rong Zhang*. Off-tumor IDO1 target engagements determine the cancer-immune set point and predict the immunotherapeutic efficacy. Journal for ImmunoTherapy of Cancer 9, e002616, (2021).
7) Duo Wang#, Jun Zhou#, Weimin Fang, Cuiqing Huang, Zerong Chen, Meng Fan, Ming-Rong Zhang, Zeyu Xiao*, Kuan Hu* & Liangping Luo*. A multifunctional nanotheranostic agent potentiates erlotinib to EGFR wild-type non-small cell lung cancer. Bioactive Materials 13, 312-323, (2021).
8) Tong Li, Xian-Mao Lu, Ming-Rong Zhang, Kuan Hu* & Zhou Li*. Peptide-based nanomaterials: Self-assembly, properties and applications. Bioactive Materials 11, 268-282, (2021).
9) Kuan Hu#, Wenyu Wu#, Lin Xie, Hao Geng, Yiding Zhang, Masayuki Hanyu, Lulu Zhang, Yinghuan Liu, Kotaro Nagatsu, Hisashi Suzuki, Jialin Guo, Yundong Wu*, Zigang Li*, Feng Wang* & Mingrong Zhang*. Whole-body PET tracking of a D-dodecapeptide and its radiotheranostic potential for PD-L1 overexpressing tumors. Acta Pharmaceutica Sinica B 12, 1363-1376, (2021)
10) Chan Wang#, Kuan Hu#, Chaochao Zhao, Yang Zou, Ying Liu, Xuecheng Qu, Dongjie Jiang, Zhe Li, Ming-Rong Zhang & Zhou Li. Customization of Conductive Elastomer Based on PVA/PEI for Stretchable Sensors. Small 16, 1904758, (2020)
11) Kuan Hu, Zhimin Yang#, Lingling Zhang#, Lin Xie, Lu Wang, Hao Xu, Lee Josephson, Steven H. Liang & Ming-Rong Zhang. Boron agents for neutron capture therapy. Coordination Chemistry Reviews 405, 213139, (2020).
12) Kuan Hu, Wei Xiong, Chengjie Sun, Chan Wang, Jingxu Li, Feng Yin, Yixiang Jiang, Ming-Rong Zhang, Zhou Li*, Xinwei Wang* & Zigang Li*. Self-Assembly of Constrained Cyclic Peptides Controlled by Ring Size. CCS Chemistry 2, 42-51, (2020).
13) Kuan Hu, Lin Xie, Yiding Zhang, Masayuki Hanyu, Zhimin Yang, Kotaro Nagatsu, Hisashi Suzuki, Jiang Ouyang, Xiaoyuan Ji, Junjie Wei, Hao Xu, Omid C. Farokhzad, Steven H. Liang*, Lu Wang*, Wei Tao* & Ming-Rong Zhang*. Marriage of black phosphorus and Cu2+ as effective photothermal agents for PET-guided combination cancer therapy. Nature communications 11, 2778, (2020).
14) Kuan Hu, Lin Xie, Masayuki Hanyu, Yiding Zhang, Lingyun Li, Xiaohui Ma, Kotaro Nagatsu, Hisashi Suzuki, Weizhi Wang* & Ming-Rong Zhang*. Harnessing the PD-L1 interface peptide for positron emission tomography imaging of the PD-1 immune checkpoint. RSC Chemical Biology 1, 214-224, (2020).
15) Wei Xiong#, Kuan Hu#, Zhe Li#, Yixiang Jiang, Zigang Li*, Zhou Li* & Xinwei Wang*. A wearable system based on core-shell structured peptide-Co9S8 supercapacitor and triboelectric nanogenerator. Nano Energy 66, 104149, (2019).
16) Zhe Li#, Kuan Hu#, Mengyan Yang#, Yang Zou#, Jinbin Yang, Min Yu, Huaying Wang, Xuecheng Qu, Puchuan Tan, Chan Wang, Xuechang Zhou* & Zhou Li*. Elastic Cu@PPy sponge for hybrid device with energy conversion and storage. Nano Energy 58, 852-861, (2019).
17) Hu Kuan, Hanyu Masayuki, Lin Xie, Yiding Zhang, Nagatsu Kotaro, Suzuki Hisashi & Ming-Rong Zhang. Developing native peptide-based radiotracers for PD-L1 PET imaging and improving imaging contrast by pegylation. Chemical Communications 55, 4162-4165, (2019).
18) Kuan Hu#, Feng Yin#, Ziyuan Zhou#, Chenshan Lian, Yinghuan Liu, Chengjie Sun, Wenjun Li, Jianing Zhang & Zigang Li. Directional assembly of a stapled α-helical peptide. Chemical Communications 55, 10484-10487, (2019).
19) Huaying Wang#, Kuan Hu#, Zhe Li#, Chan Wang, Min Yu, Zigang Li* & Zhou Li*. Black Phosphorus Nanosheets Passivation Using a Tripeptide. Small 14, 1801701, (2018).
20) Chan Wang#, Kuan Hu#, Wenjian Li, Huaying Wang, Hu Li, Yang Zou, Chaochao Zhao, Zhe Li, Min Yu & Puchuan Tan, Zhou Li. Wearable Wire-Shaped Symmetric Supercapacitors Based on Activated Carbon-Coated Graphite Fibers. ACS applied materials & interfaces 10, 34302-34310, (2018).
21) Wenjun Li#, Kuan Hu#, Qingzhou Zhang, Dongyuan Wang, Yue Ma, Zhanfeng Hou, Feng Yin* & Zigang Li*. N terminal N-methylation modulates chiral centre induced helical (CIH) peptides' biophysical properties. Chemical Communications 54, 1865-1868, (2018).
22) Kuan Hu*, Chao Zheng, Miao An, Xiaohui Ma* & Lu Wang*. A peptide-based supercapacitor and its performance improvement via TiO2 coating. Journal of Materials Chemistry A 6, 8047-8052, (2018).
23) Kuan Hu#, Yixiang Jiang#, Wei Xiong, Hu Li, Pei-Yu Zhang, Feng Yin, Qianling Zhang, Hao Geng, Fan Jiang*, Zhou Li*, Xinwei Wang* & Zigang Li*. Tuning peptide self-assembly by an in-tether chiral center. Science Advances 4, eaar5907, (2018).
24) Feng Yin#, Kuan Hu#, Yangzi Chen, Mengying Yu, Dongyuan Wang, Qianqian Wang, Ken-Tye Yong, Fei Lu*, Yongye Liang* & Zigang Li*. SiRNA Delivery with PEGylated Graphene Oxide Nan osheets for Combined Photothermal and Genetherapy for Pancreatic Cancer. Theranostics 7, 1133-1148, (2017).
25) Kuan Hu#, Feng Yin#, Mengyin Yu, Chengjie Sun, Jingxu Li, Yujie Liang, Wenjun Li, Mingsheng Xie, Yuanzhi Lao, Wei Liang* & Zi-gang Li*. In-Tether Chiral Center Induced Helical Peptide Modulators Target p53-MDM2/MDMX and Inhibit Tumor Growth in Stem-Like Cancer Cell. Theranostics 7, 4566-4576, (2017).
26) Kuan Hu#, Chengjie Sun#, Mengying Yu, Wenjun Li, Huacan Lin, Jialin Guo, Yixiang Jiang, Chengxiang Lei & Zigang Li. Dual In-Tether Chiral Centers Modulate Peptide Helicity. Bioconjugate Chemistry 28, 1537-1543, (2017).
27) Kuan Hu#, Chengjie Sun#, Dan Yang, Yujie Wu, Chuan Shi, Longjian Chen, Tao Liao, Jialin Guo, Yinghuan Liu & Zigang Li. A precisely positioned chiral center in an i, i + 7 tether modulates the helicity of the backbone peptide. Chemical Communications 53, 6728-6731, (2017).
28) Kuan Hu#, Chengjie Sun# & Zigang Li. Reversible and Versatile On-Tether Modification of Chiral-Center-Induced Helical Peptides. Bioconjugate Chemistry 28, 2001-2007, (2017).
29) Kuan Hu#, Wenjun Li#, Mengying Yu, Chengjie Sun & Zigang Li. Investigation of Cellular Uptakes of the In-Tether Chiral-Center-Induced Helical Pentapeptides. Bioconjugate Chemistry 27, 2824-2827, (2016).
30) Kuan Hu, Hao Geng, Qingzhou Zhang, Qisong Liu, Mingsheng Xie, Chengjie Sun, Wenjun Li, Huacan Lin, Fan Jiang, Tao Wang*, Yun-Dong Wu* & Zigang Li*. An In-tether Chiral Center Modulates the Helicity, Cell Permeability, and Target Binding Affinity of a Peptide. Angewandte Chemie International Edition 55, 8013-8017, (2016).

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