药用天然产物合成生物学研究，主要包括：
1. 解析天然药用分子生物合成机制，发掘新颖功能酶
2. 创建药用分子生物合成细胞工厂，实现绿色生物制造
3. 联合酶法-化学法进行天然产物结构优化，用于新药发现
围绕以上研究方向，先后主持国自然优秀青年科学基金、原创探索、面上等国家级项目；在Nature Communications、Angewandte Chemie International Edition等国际权威期刊发表研究论文20余篇，申请专利10余项，授权4项；担任Acta Pharmaceutica Sinica B与Chinese Chemical Letters等期刊青年编委、中华中医药学会青年委员。

1. Kebo Xie#*, Xiaolin Zhang#, Songyang Sui, Fei Ye* and Jungui Dai*. Exploring and applying the substrate promiscuity of a C-glycosyltransferase in the chemo-enzymatic synthesis of bioactive C-glycosides. Nature Communications, 2020, 11, 1-12 (Q1区，第一兼共同通讯作者).
2. Ruiqi Yan#, Binghan Xie#, Kebo Xie#*, Qi Liu#, Songyang Sui, Shuqi Wang, Dawei Chen, Jimei Liu, Ridao Chen, Jungui Dai* & Lin Yang*. Unravelling and reconstructing the biosynthetic pathway of bergenin. Nature Communications, 2024, 15, 3539. (Q1区，共同第一兼共同通讯作者)
3. Changkang Li#, Xinxin Yin#, Shuai Wang, Songyang Sui, Jimei Liu, Xincheng Sun, Jinming Di, Ridao Chen, Dawei Chen, Yaotian Han, Kebo Xie*, Jungui Dai*. A Cytochrome P450 Enzyme Catalyses Oxetane Ring Formation in Paclitaxel Biosynthesis. Angewandte Chemie International Edition, 2024, e202407070. (Q1区，共同通讯作者)
4. Kebo Xie#*, Qian Zhang#, Fei Ye, Jungui Dai*. A multi-enzymatic cascade reaction for the synthesis of bioactive C-oligosaccharides. Chinese Chemical Letters, 2024, 35, 109028. (Q1区，共同第一兼共同通讯作者).
5. Kebo Xie, Ridao Chen, Jianhua Li, Ruishan Wang, Dawei Chen, Xiaoxiang Dou, and Jungui Dai*, Exploring the catalytic promiscuity of a new glycosyltransferase from Carthamus tinctorius, Organic Letters, 2014, 16, 4874-4877. (Q1区，第一作者)
6. Kebo Xie, Ridao Chen, Dawei Chen, Jianhua Li, Ruishang Wang, Lin Yang and Jungui Dai*, Enzymatic N-Glycosylation of Diverse Arylamine Aglycones by a Promiscuous Glycosyltransferase from Carthamus tinctorius. Advanced Synthesis & Catalysis, 2017, 359, 603‒608. Q1区，第一作者)
7. Songyang Sui#, Kebo Xie#, Ruimingqian Guo, Jungui Dai*, and Lin Yang*. Molecular characterization of a stereoselective and promiscuous flavanone 3-hydroxylase from Carthamus tinctorius L. Journal of Agricultural and Food Chemistry, 2023, 71, 1679-1689. (Q1区, 共同第一作者)
8. Tian Yue, Ridao Chen, Dawei Chen, Jimei Liu, Kebo Xie* and Jungui Dai*, Enzymatic Synthesis of Bioactive O-Glucuronides Using Plant Glucuronosyltransferases, Journal of Agricultural and Food Chemistry, 2019, 67, 6275-6284. (Q1区，共同通讯作者)
9. Yujiao Zhang#, Kebo Xie#, Aijing Liu, Ridao Chen, Dawei Chen, Lin Yang, Jungui Dai* Enzymatic biosynthesis of benzylisoquinoline alkaloid glycosides via promiscuous glycosyltransferases from Carthamus tinctorius. Chinese Chemical Letters, 2019, 30, 443-446. (Q1区，共同第一作者)
10. Kebo Xie#, Xiaoxiang Dou#, Ridao Chen, Dawei Chen, Cheng Fang, Zhiyan Xiao and Jungui Dai*, Molecular Characterization and Phylogenetic Analysis of Two Novel Fungal Phenolic UDP-Glycosyltransferases from Absidia coerulea and Rhizopus japonicus. Applied and Environmental Microbiology, 2017, AEM-03103. (Q1区，共同第一作者)