1．药物分子设计与合成
2．活性天然产物的全合成及结构修饰
3．创新药物的研发

1. Discovery of a novel serine-targeting covalent inhibitor against hCES2A for treating drug-induced diarrhea and ulcerative colitis, Danyang Hu#, Hairong Zeng#, Wenxuan Li#, Ya Zhang#, Xiaoqian Chi, Xiaoyu Liu, Haijing Zhang*, Guangbo Ge*, Xiaozhen Jiao*, and Ping Xie., J Med. Chem., 2025, DOI: 10.1021/acs.jmedchem.5c00563. (IF=6.9 )
2. New Bysspectin A Derivatives as Potent Inhibitors of Human Carboxylesterase 2A, Wenxuan Li#, Ya Zhang#, Yuanyuan Wu#, Guanghao Zhu, Xiaoyu Liu, Yunqing Song, Bo Ma, Sheng Lin, Guangbo Ge*, Xiaozhen Jiao*, Ping Xie，Eur. J. Med. Chem., 2023, 259, 115708. (IF=6.7 )
3. Total Synthesis of the Proposed Structure of Characellide B, Yong Wang†, Zhenwei Wang†, Zhe Wang†, Xiaoyu Liu, Yingjun Jiang, Xiaozhen Jiao* and Ping Xie*, Org. Lett., 2021, 23, 3680-3684. (IF=6.091 )
4. (+)-Isocryptotanshinone derivatives and its simplified analogs as STAT3 signaling pathway inhibitors, Xiang Shi# , Ting ting Du #, Zhihui Zhang #, Xiaoyu Liu, Ying Yang , Nina Xue , Xiaozhen Jiao* , Xiaoguang Chen * , Ping Xie *, Bioorganic Chemistry , 127 (2022) ,106015. （IF=5.307）
5. Total Synthesis of (-)-Levesquamide, Yingjun Jiang, Xiaoyu Liu, Wenxuan Li, Xiaozhen Jiao*, Ping Xie*, J Org. Chem., 2023, 88, 3981-3986. (IF=4.198 )
6. Convenient synthesis of perhydrobenz[e]indene triketone, a key intermediate for the total synthesis of stelletins, Yang Cao, Xiaoyu Liu, Zhe Wang, Yuan Wang, Xiaozhen Jiao * and Ping Xie*, Org. & Bio. Chem., 2023, 21, 3850-3857. (IF=3.876)
7. Total synthesis of (±) commiphoranes C–D and their epimers，Xiaoyu Liu#, Haidong Deng#, Yingjun Jiang, Yang Cao, Zhe Wang, Xiaozhen Jiao * and Ping Xie, Org. & Bio. Chem., 2022, 20(10): 2102-2108.（IF=3.876）
8. Total Synthesis of Bysspectin A, Feilong Yang, Xiaoyu Liu, Xiang Shi, Yong Wang, Guoru Hu, Sheng Lin, Xiaozhen Jiao* and Ping Xie*, Tetrahedron, 2019, 75, 3101-3107. (IF=2.33 )
9. Asymmetric total synthesis of (t)-isocryptotanshinone and formal synthesis of (-)-cryptotansh- inone, Xiang Shi, Xiaoyu Liu, Feilong Yang, YongWang, ZhenweiWang, Xiaozhen Jiao*, Ping Xie*, Tetrahedron, 2019, 75, 3962-3967. (IF=2.33 )
10. Design, Synthesis and Biological Evaluation of Substituted (+)-SG-1 Derivatives as Novel anti-HIV Agents. Xiaoyu Liu，Panpan Chen, Xiaoyu Li, Mingyu Ba, Xiaozhen Jiao*, Ying Guo*, Ping Xie, Bio. & Med. Chem. Lett., 2018, 28(10): 1699-1703 (IF=2.442)
11. Enantioselective Total Synthesis of Colomitides and their Absolute Configuration Determina- tion and Structural Revision. Hongguang Yang, Xiaoyu Liu, Xiaoyu Li, Xiang Shi, Feilong Yang, Xiaozhen Jiao*, Ping Xie*. Org. & Bio. Chem., 2017, 15, 3728- 3735. (IF=3.423 )
12. Discovery of novel N-substituted-prolinamido indazoles as potent Rho kinase inhibitors and vasorelaxation agents, Yangyang Yao†，Renze Li†, Xiaoyu Liu, Feilong Yang, Ying Yang, Hongguang Yang, Xiaoyu Li, Xiang Shi, Tianyi Yuan, Lianhua Fang, Guanhua Du, Xiaozhen Jiao*, Ping Xie*. Molecules, 2017, 22, 1766-1781. (IF=3.098 )