完成临床学习和工作后，获McMaster大学免疫学博士学位，并在NIH做博士后研究。来到药物所后，担任课题组长，主要从事疫苗引起细胞免疫反应方面的研究，旨在阐明T细胞免疫的细胞与分子机制，特别是在粘膜表面对抗传染性和炎症以及癌症。另外在疾病模型中探索细胞重新编的治疗潜力，开展基础和应用研究，寻找更好的治疗方法。

主要研究方向包括免疫反应诱导与新型疫苗设计、疫苗与药物高效递送策略、细胞分化与效应分子机制、细胞再生潜能与组织损伤修复。利用多种细胞模型开展新药筛选，研究药物对干细胞及免疫细胞生物学特性、生存微环境、增值分化调控的影响，进一步探索疾病发展、细胞健康与异常、再生和组织修复等方面机制，寻求干细胞和疫苗干预技术在慢性疾病、自身免疫性疾病、组织损伤、退行性病变、传染病上的应用新途径。研究课题涉及细胞生物学、疫苗免疫学、药物传递系统、细胞激活与迁移、T记忆细胞、高效杀伤淋巴细胞以及新型疫苗载体和佐剂等。

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