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研究员

张森

职 称:研究员

所属科室:药理学研究室

导师类别:硕士生导师

联系方式:15201539761
zhangs@imm.ac.cn

所属重点实验室:

个人简介

药理学博士,研究员,1979年8月生。2002年从山东大学取得生物化学学士学位,而后分别在中国协和医科大学肿瘤研究所和药物研究所取得硕士和博士学位。2008-2011年,新加坡南洋理工大学访问学者。长期从事新药开发,主要参与过国家1.1类新药硝克柳胺和中药1.3类圆锥绣球提取物的开发工作。曾主持国家自然科学基金、北京市自然科学基金、教育部重点实验专项基金、中国医学科学院基本科研业务经费、中国医学科学院医学与健康科技创新工程子任务以及十三五重大专项子任务;参与国自然重大项目、国家重点研发计划、北京“十病十药”科委项目、北京市自然基金重点项目以及863“结直肠癌早期诊断”等项目。以第一作者或通讯作者发表SCI收录文章近40篇,申请专利11项,授权4项,在研新药3项。

研究方向

目前主要研究领域为肿瘤药理学和慢性肾脏病药理学。利用现代药理学的新思路和新方法,结合大数据分析和AI新算法,从生物数据库中预测同疾病相关核酸靶点和蛋白靶点。同时,利用分子生物学的方法,验证靶点的有效性,并筛选有效治疗药物。 研究领域还包括调节肠道菌群治疗慢性肾病以及增敏肿瘤治疗等。细分领域包括色氨酸代谢和内质网应激参与慢性肾脏病进展的分子机制。

发表论文

1. Shi X, Li Z, Lin W, Shi W, Hu R, Chen G, Sen Zhang. Altered intestinal microbial flora and metabolism in patients with idiopathic membranous nephropathy. Am J Nephrol. 2023.
2. Zhan X-K, Liu X-K, Zhang S*, Chen H*. Expression and prognosis of inducible T-cell co-stimulator and its ligand in Chinese stage I–III lung adenocarcinoma patients. Animal Models and Experimental Medicine. 2023, 6(5): 464-473.
3. Haijie Wu, Xiaohu Shi, Yingda Zang, Xiaodi Zhao, Xikun Liu, Weida Wang, Wenying Shi, Clarence T T Wong, Li Sheng, Xiaoguang Chen, Sen Zhang, 7-hydroxycoumarin-β-D-glucuronide protects against cisplatin-induced acute kidney injury via inhibiting p38MAPK-mediated apoptosis in mice, Life sciences, 2023, 327,121864.
4. Taoxia Wang, Shubei Cui, Xiaoli Liu, Li Han, Xiaoting Duan, Shuning Feng, Sen Zhang*, Guiying Li*, LncTUG1 ameliorates renal tubular fibrosis in experimental diabetic nephropathy through the miR-145-5p/dual-specificity phosphatase 6 axis, Renal failure, 2023, 45(1),2173950.
5. Haijie Wu, Xiaoguang Chen, Sen Zhang*, Jiaxin Li*. Gut Microbiota, the Potential Biological Medicine for Prevention, Intervention and Drug Sensitization to Fight Diseases. Nutrients, 2022,14(20):4220.
6. Haijie Wu*, Binghan Jia*, Xiaodi Zhao*, Haoyu Zhang, Zhaojun Li, Weida Wang, Xiaoguang Chen, Sen Zhang,Pathophysiology and system biology of rat c-BSA induced immune complex glomerulonephritis and pathway comparison with human gene sequencing data. International immunopharmacology, 2022, 109, 108891.
7. Zhang Ying, Li Zhaojun, Wu Haijie, Wang Jing, Zhang Sen. Esculetin alleviates murine lupus nephritis by inhibiting complement activation and enhancing Nrf2 signaling pathway. Journal of Ethnopharmacology. 2022; 288:115004. IF:5.4
8. Weida Wang, Li Sheng, Yuanyuan Chen, Zhaojun Li, Haijie Wu, Jie Ma, Dongming Zhang, Xiaoguang Chen*, Sen Zhang*. Total coumarin derivates from Hydrangea paniculata attenuate renal injuries in cationized-BSA induced membranous nephropathy by inhibiting complement activation and interleukin 10-mediated interstitial fibrosis, phytomedicine, 2022;96:153886.
9. Meng Jin, Li Kong, Ying Han, Sen Zhang*. Gut microbiota enhances the chemosensitivity of hepatocellular carcinoma to 5-fluorouracil in vivo by increasing curcumin bioavailability. phytotherapy research, 2021, 35(10):5823-5837.
10. Yu zhang, Xiaofeng Huang, Jin Liu, Guo Chen, Chengjun Liu, Sen Zhang*, Jiaxin Li*. New insight into long non-coding RNAs associated with bone metastasis of breast cancer based on an integrated analysis, Cancer Cell international, 2021, 21(1), 372.
11. Yuanyuan Chen, Xiaoguang Chen*, Sen Zhang*, Druggability of lipid metabolism modulation against renal fibrosis. Acta Pharmacologica Sinica, 2022, 43(3):505-519.
12. Yuanyuan Chen, Zhaojun Li, Xiaoguang Chen*, Sen Zhang*, Long non-coding RNAs: from disease code to drug role. Acta Pharmaceutica Sinica B, 2021, 11(2), 340-354.
13. Weida Wang, Zhaojun Li, Yuanyuan Chen, Haijie Wu, Sen Zhang* and Xiaoguang Chen, Prediction Value of Serum NGAL in the Diagnosis and Prognosis of Experimental Acute and Chronic Kidney Injuries, Biomolecules, 2020, 10(7):981.
14. Zhang Yu, Han Wendan, Zhang Sen*. Seeking for correlative genes and signaling pathways with bone metastasis from breast cancer by integrated analysis, Frontiers in Oncology. 2019, 9:138. DOI: 10.3389/fonc.2019.00138.
15. Zhang Sen, Wang Weida, Ma Jie, Sheng Li, Zhang Dongming, Chen Xiaoguang*, Coumarin glycosides from Hydrangea paniculata slow down the progression of diabetic nephropathy by targeting Nrf2 anti-oxidation and smad2/3-mediated profibrosis. Phytomedicine, 2019,57, 385-395.
16. Zhang Sen, Wang Weida, Yan Li, Li Zhaojun, Xue Nina, Chen Xiaoguang, Nicousamide attenuates renal dysfunction and glomerular injury in remnant kidneys by inhibiting TGF-β1 internalisation and renin activity. European journal of pharmacology, 2019, 845:74-84.
17. Zhang Sen, Ma Jie, Sheng Li, Zhang Dongming, Chen Xiaoguang*, Yang Jingzhi, Dongjie Wang. Total Coumarins from Hydrangea paniculata Show Renal Protective Effects in Lipopolysaccharide-Induced Acute Kidney Injury via Anti-inflammatory and Antioxidant Activities. Frontiers in Pharmacology. 2017;8(872). DOI: 10.3389/fphar.2017.00872.
18. Zhang Sen, Ma Jie, Yang Jingzhi, Wang Dongjie, Zhang Dongming, Chen Xiaoguang*. Total coumarins from Hydrangea paniculata protect against cisplatin-induced acute kidney damage in mice by suppressing renal inflammation and apoptosis, Evidence-Based Complementary and Alternative Medicine, 2017;2017:5350161, DOI:10.1155/2017/5350161.
19. Zhang Sen, Wang Dongjie, Xue Nina, Ji Ming, Lai Fangfang, Jinjin, Chen Xiaoguang. Nicousamide protects kidney podocyte by inhibiting the TGFβ receptor II phosphorylation and AGE-RAGE signaling, American Journal of Translational Research, 2017, 9(1):115-125.
20. Ma Pei#, Zhang Sen#, Su Qinglin, Qiu Guixing, Wu Zhihong. Protective effects of icariin on cisplatin-induced acute renal injury in mice, American Journal of Translational Research, 2015;7(10):2105-2114.
21. Xiao-kai Zhan#,*, Sen Zhang#, Bang-wei Cao, Jin-wan Wang, Jun-ling Li, Yong-kun Sun, Wen Zhang, Lin Yang, Ai-ping Zhou, Yi-he bali Chi, Ye-xiong Li, Jian-hui Ma and Chang-ling Li. Clinicopathological characteristics and treatment outcomes of Chinese patients with genitourinary embryonal rhabdomyosarcoma. World J Surg Oncol, 2015; 13: 190.
22. Sen Zhang, Hongqi Xin, Yan Li, Dongming Zhang, Jing Shi, Jingzhi Yang, and Xiaoguang Chen. Skimmin, a Coumarin from Hydrangea paniculata, slows down the Progression of Membranous Glomerulonephritis by Anti-Inflammatory Effects and Inhibiting Immune Complex Deposition. Evidence-Based Complementary and Alternative Medicine. 2013:819296. doi: 10.1155/2013/819296
23. Sen Zhang, Xiao Kai Zhan, Jin Jing, Zhang Yi, Zhou Wanqi, Chemosensitizing activities of cyclotides from Clitoria ternatea in paclitaxel-resistant lung cancer cells, Oncology Letters, 5: 641-644, 2013.
24. Sen Zhang, Jingzhi Yang, Hongyan Li, Yan Li, Xiaoguang Chen. Skimmin, a coumarin, suppresses the streptozotocin-induced diabetic nephropathy in wistar rats. European Journal of Pharmacology, 692(1-3): 78-83, 2012.
25. Giang Kien Truc Nguyen, Sen Zhang, Wei Wang, Clarence Tsun Ting Wong, Ngan Thi Kim Nguyen, and James P. Tam*, Discovery of a linear cyclotide from the bracelet subfamily and its disulfide mapping by top-down mass spectrometry. The journal of biological chemistry, 2011, 286(52), 44833-44844.
26. Giang Kien Truc Nguyen, Sen Zhang, Ngan Thi Kim Nguyen, Phuong Quoc Thuc Nguyen, Ming Sheau Chiu, Antony Hardjojo, James P. Tam*, Discovery and Characterization of Novel Cyclotides Originated from Chimeric Precursors Consisting of Albumin-1 Chain and Cyclotide Domains in the Fabaceae Family. The journal of biological chemistry vol. 2011, 286(27), 24275–24287.

专著

专利

1. 阮海斌,张森。舒尼替尼在治疗疾病中的应用;中国,申请号:2023108434135;申请日:2023.07.11
2. 张森,贾冰寒,石文莹,刘喜坤,长链非编码 RNA-LINC01094 在筛选预防或治疗慢性肾病药物中的应用;中国,申请号:2023104627143;申请日:2023.4.26
3. 张东明,陈晓光,张森,马洁,臧应达,李创军,陈欣怡,吴海杰,赵晓迪,黄蕾,一类香豆素苷及其制备方法和其药物组合物与用途,中国,申请号: 202211107702.0;申请日:2022.9.13.
4. 张森,史晓虎,王琰,李昭君,吴海杰,陈园园,赵晓迪, 一类肠道菌在预防或治疗肾病综合征药物或生物制剂中的应用,中国,申请号:202210392727.3,申请日:2022.4.15.
5. 张东明,臧应达,张森,吴海杰等。一类混源萜及其制备方法和其药物组合物与用途。中国,申请号:202111169421.3,申请日:2021.10.8。
6. 王琰,张崇敬,曹之宪,陈晓光,张森,徐蔓依,于航,潘立斌。一种用于早期结直肠肿瘤的靶向多肽化合物与应用;中国。申请号:202111570465.7;申请日:2021.05.25。
7. 张森,李昭君,王伟达,陈园园,吴海杰。一组用于诊断特发性膜性肾病的微生物标志物组合及其应用。中国。申请号:202011130811.5。申请日:2020.10.21.
8. 詹晓凯,刘洁,张森,林琳,郝学志。一种利用拉曼成像技术检测耐药性的方法。中国,专利号:ZL201810278859.7 ,申请日:2018-3-30;授权公告日:2021-3-5。
9. 王素娟,关晓兵,王嘉祺,包捷,贺浩珂,张森,汪苑苑,石建功。一种改良型低毒增生平组合物及其制备方法和用途, 专利申请日:2018.6.26, 中国, 专利号:ZL201810666698.9。授权公告日:2022年6月21日。
10. 王琰,陈晓光,杨潇骁,曹之宪,李燕,温宝莹,冯茹,张森,黄敏。一种多肽、及其在结直肠癌的早期诊断中的应用; 授权号:ZL201810026559.X;申请日:2018.1.15。授权日: 2022.7.29. 中国。
11. 张东明,陈晓光,杨敬芝,张森,马洁,李燕。圆锥绣球总香豆素苷、其制备方法及其组合物与用途;专利号:ZL201610147475.2;授权日:2021.8.13.中国。

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