目前主要研究领域为肿瘤药理学和肾脏病药理学。利用现代药理学的新思路和新方法，结合大数据分析和AI新算法，从生物数据库中预测同疾病相关蛋白靶点。同时，利用分子生物学的方法，验证靶点的有效性，并筛选有效治疗药物。 研究领域还包括内质网和线粒体药理学、多发性骨髓瘤耐药以及化疗保护药物的开发等。细分领域包括色氨酸代谢、内质网-线粒体互作、慢性肾病和化疗后脏器损伤的分子机制。

1. Yu Zhang, Xiaodi Zhao, Zhiling Ma, Peng Wang, Sen Zhang, Jiaxin Li, Peripheral ICOS+CD4 T cell frequency: an indicator for short-term progression in resectable advanced gastric cancer following platinum-based chemotherapy. journal of investigative medicine, 2025
2. Ting Wang, Xiufeng Liao, Xiaodi Zhao, Kai Chen, Yangzhonghui Chen, Hui Wen, Dali Yin, Yuchen Wang, Bin Lin, Sen Zhang, Huaqing Cui, Rational design of 2-benzylsulfinyl-benzoxazoles as potent and selective in‐doleamine 2, 3-dioxygenase 1 inhibitors to combat inflammation, Bioorganic Chemistry, 2024, 152, 107740.
3. Ying-Da Zang, Hai-Jie Wu, Xin-Yi Chen, Zhi-ling Ma, Chuang-Jun Li, Jie Ma, Xiao-Guang Chen, Li Sheng,* Sen Zhang* and Dong-Ming Zhang* Synthesis and Biological Evaluation of Novel Psidium Meroterpenoid Derivatives Against Cisplatin-induced Acute Kidney Injury, Journal of Medicinal Chemistry, 2024, 67(16), 14234-14255.
4. Wenying Shi, Zhaojun Li, Weida Wang, Xikun Liu, Haijie Wu, Xiaoguang Chen, Xunrong Zhou, Sen Zhang，Dynamic gut microbiome-metabolome in c-BSA induced experimental immune-complex glomerulonephritis and effect of losartan and MMF on microbiota modulation, Journal of Pharmaceutical Analysis, 2024, 14(4):100931.
5. Yuanyuan Chen, Xikun Liu, Jie Ma, Weida Wang, Zhaojun Li, Haijie Wu, Zhanxi Lu, Dongming Zhang, Xiaoying Zhang, Yu Zhang, Sen Zhang, Hydrangea paniculata coumarins alleviate adriamycin-induced renal lipotoxicity through activating AMPK and inhibiting C/EBPβ. Journal of ethnopharmacology, 2024, (329): 118156
6. Xiaokai Zhan, Xikun Liu, Li Rang, Man Shen, Jiajia Zhang, Ran Tang, Sibin Fan, Fengyi, Zhao, Xin Li, Xiaoying Zhang, Zhongxia, Huang, Sen Zhang. Detection of lenalidomide metabolites in urine to discover drug-resistant compounds. Clinica Chimica Acta. 2024; 553:117707.
7. Zhaojun Li, Xingguang Zhang, Haijie Wu, Zhiling Ma, Xikun Liu, Jie Ma, Dongming Zhang, Li Sheng, Xiaoguang Chen and Sen Zhang, Hydrangea paniculata coumarins attenuate experimental membranous nephritis by bidirectional interactions with the gut microbiota, Communications Biology, 2023, 6, 1189.
8. Xiaohu Shi, Zhaojun Li, Weifeng Lin, Wenying Shi, Rongrong Hu, Gang Chen, Xuemei Li, Xuewang Li, Sen Zhang. Altered intestinal microbial flora and metabolism in patients with idiopathic membranous nephropathy. American Journal of Nephrology. 2023, 54(11-12):451-470.
9. Zhan X-K, Liu X-K, Zhang S*, Chen H*. Expression and prognosis of inducible T-cell co-stimulator and its ligand in Chinese stage I–III lung adenocarcinoma patients. Animal Models and Experimental Medicine. 2023, 6(5): 464-473.
10. Haijie Wu, Xiaohu Shi, Yingda Zang, Xiaodi Zhao, Xikun Liu, Weida Wang, Wenying Shi, Clarence T T Wong, Li Sheng, Xiaoguang Chen, Sen Zhang, 7-hydroxycoumarin-β-D-glucuronide protects against cisplatin-induced acute kidney injury via inhibiting p38MAPK-mediated apoptosis in mice, Life sciences, 2023, 327,121864.
11. Taoxia Wang, Shubei Cui, Xiaoli Liu, Li Han, Xiaoting Duan, Shuning Feng, Sen Zhang*, Guiying Li*, LncTUG1 ameliorates renal tubular fibrosis in experimental diabetic nephropathy through the miR-145-5p/dual-specificity phosphatase 6 axis, Renal failure, 2023, 45(1),2173950.
12. Haijie Wu, Xiaoguang Chen, Sen Zhang*, Jiaxin Li*. Gut Microbiota, the Potential Biological Medicine for Prevention, Intervention and Drug Sensitization to Fight Diseases. Nutrients, 2022,14(20):4220.
13. Haijie Wu*, Binghan Jia*, Xiaodi Zhao*, Haoyu Zhang, Zhaojun Li, Weida Wang, Xiaoguang Chen, Sen Zhang，Pathophysiology and system biology of rat c-BSA induced immune complex glomerulonephritis and pathway comparison with human gene sequencing data. International immunopharmacology, 2022, 109, 108891.
14. Zhang Ying, Li Zhaojun, Wu Haijie, Wang Jing, Zhang Sen. Esculetin alleviates murine lupus nephritis by inhibiting complement activation and enhancing Nrf2 signaling pathway. Journal of Ethnopharmacology. 2022; 288:115004. IF:5.4
15. Weida Wang, Li Sheng, Yuanyuan Chen, Zhaojun Li, Haijie Wu, Jie Ma, Dongming Zhang, Xiaoguang Chen*, Sen Zhang*. Total coumarin derivates from Hydrangea paniculata attenuate renal injuries in cationized-BSA induced membranous nephropathy by inhibiting complement activation and interleukin 10-mediated interstitial fibrosis, phytomedicine, 2022;96:153886.
16. Meng Jin, Li Kong, Ying Han, Sen Zhang*. Gut microbiota enhances the chemosensitivity of hepatocellular carcinoma to 5-fluorouracil in vivo by increasing curcumin bioavailability. phytotherapy research, 2021, 35(10):5823-5837.
17. Yu zhang, Xiaofeng Huang, Jin Liu, Guo Chen, Chengjun Liu, Sen Zhang*, Jiaxin Li*. New insight into long non-coding RNAs associated with bone metastasis of breast cancer based on an integrated analysis, Cancer Cell international, 2021, 21(1), 372.
18. Yuanyuan Chen, Xiaoguang Chen*, Sen Zhang*, Druggability of lipid metabolism modulation against renal fibrosis. Acta Pharmacologica Sinica, 2022, 43(3):505-519.
19. Yuanyuan Chen, Zhaojun Li, Xiaoguang Chen*, Sen Zhang*, Long non-coding RNAs: from disease code to drug role. Acta Pharmaceutica Sinica B, 2021, 11(2), 340-354.
20. Weida Wang, Zhaojun Li, Yuanyuan Chen, Haijie Wu, Sen Zhang* and Xiaoguang Chen, Prediction Value of Serum NGAL in the Diagnosis and Prognosis of Experimental Acute and Chronic Kidney Injuries, Biomolecules, 2020, 10(7):981.
21. Zhang Yu, Han Wendan, Zhang Sen*. Seeking for correlative genes and signaling pathways with bone metastasis from breast cancer by integrated analysis, Frontiers in Oncology. 2019, 9:138. DOI: 10.3389/fonc.2019.00138.
22. Zhang Sen, Wang Weida, Ma Jie, Sheng Li, Zhang Dongming, Chen Xiaoguang*, Coumarin glycosides from Hydrangea paniculata slow down the progression of diabetic nephropathy by targeting Nrf2 anti-oxidation and smad2/3-mediated profibrosis. Phytomedicine, 2019,57, 385-395.
23. Zhang Sen, Wang Weida, Yan Li, Li Zhaojun, Xue Nina, Chen Xiaoguang, Nicousamide attenuates renal dysfunction and glomerular injury in remnant kidneys by inhibiting TGF-β1 internalisation and renin activity. European journal of pharmacology, 2019, 845:74-84.
24. Zhang Sen, Ma Jie, Sheng Li, Zhang Dongming, Chen Xiaoguang*, Yang Jingzhi, Dongjie Wang. Total Coumarins from Hydrangea paniculata Show Renal Protective Effects in Lipopolysaccharide-Induced Acute Kidney Injury via Anti-inflammatory and Antioxidant Activities. Frontiers in Pharmacology. 2017;8(872). DOI: 10.3389/fphar.2017.00872.
25. Sen Zhang, Xiao Kai Zhan, Jin Jing, Zhang Yi, Zhou Wanqi, Chemosensitizing activities of cyclotides from Clitoria ternatea in paclitaxel-resistant lung cancer cells, Oncology Letters, 5: 641-644, 2013.
26. Sen Zhang, Jingzhi Yang, Hongyan Li, Yan Li, Xiaoguang Chen. Skimmin, a coumarin, suppresses the streptozotocin-induced diabetic nephropathy in wistar rats. European Journal of Pharmacology, 692(1-3): 78-83, 2012.
27. Giang Kien Truc Nguyen, Sen Zhang, Wei Wang, Clarence Tsun Ting Wong, Ngan Thi Kim Nguyen, and James P. Tam*, Discovery of a linear cyclotide from the bracelet subfamily and its disulfide mapping by top-down mass spectrometry. The journal of biological chemistry, 2011, 286(52), 44833-44844.
28. Giang Kien Truc Nguyen, Sen Zhang, Ngan Thi Kim Nguyen, Phuong Quoc Thuc Nguyen, Ming Sheau Chiu, Antony Hardjojo, James P. Tam*, Discovery and Characterization of Novel Cyclotides Originated from Chimeric Precursors Consisting of Albumin-1 Chain and Cyclotide Domains in the Fabaceae Family. The journal of biological chemistry vol. 2011, 286(27), 24275–24287.