1. 药物化学：治疗耐药细菌感染、肿瘤以及代谢性疾病等活性先导物的结构优化和成药性评价。
2. 新药开发：化学原料药合成工艺开发与注册申报。

1. Bo Feng#, Huabin Hu#, Jin Xiang#, Guangxu Wu, Zihao Zhu, Gao Zhang, Jie Zhang,Weidong Pan, Wenxuan Zhang*, Tianlei Li*, Song Wu*. Discovery of novel triphenylphosphonium conjugated pleuromutilin with enhanced anti-MRSA effect and broaden antibacterial spectrum, European Journal of Medicinal Chemistry，2025, 294, 117731.
2. Xinyu Luo#, Guangxu Wu#, Jing Feng, Jie Zhang, Hengjian Fu, Hang Yu, Zunsheng Han, Wansen Nie, Zihao Zhu, Bo Liu, Weidong Pan, Beibei Li, Yan Wang, Chi Zhang, Tianlei Li* , Wenxuan Zhang*, Song Wu*. Novel pleuromutilin derivatives conjugated with phenyl-sulfide and boron-containing moieties as potent antibacterial agents againstantibiotic-resistant bacteria. European Journal of Medicinal Chemistry, 2024, 277, 116745.
3. Zhuo Cheng, Bei-Bei He, Kangfan Lei, Ying Gao, Yuqi Shi, Zheng Zhong, Hongyan Liu, Runze Liu, Haili Zhang, Song Wu, Wenxuan Zhang*, Xiaoyu Tang* and Yong-Xin Li *. Rule-based omics mining reveals antimicrobial macrocyclic peptides against drug-resistant clinical isolates. Nature Communications, 2024,15(1), 4901.
4.Xiaolei Ma#, Xiaoyou Yu#, Rui Li#, Jinjin Cui, Haoyang Yu, Ling Ren, Jiandong Jiang, Wenxuan Zhang,* Lulu Wang*, Berberine-silybin salt achieves improved anti-nonalcoholic fatty liver disease effect through regulating lipid metabolism[J]. Journal of Ethnopharmacology, 2024, 319: 117238.
5.Xintong Zhao,# Jing Feng,# Jie Zhang,# Zunsheng Han, Yuhua Hu, Hui-Hui Shao, Tianlei Li, Jie Xia, Kangfan Lei, Weiping Wang, Fangfang Lai, Yuan Lin, Bo Liu, Kun Zhang, Chi Zhang, Qingyun Yang, Xinyu Luo, Hanyilan Zhang, Chuang Li, Wenxuan Zhang,* Song Wu*. Discovery and druggability evaluation of pyrrolamide-type GyrB/ParE inhibitor against drug-resistant bacterial infection[J]. Acta Pharmaceutica Sinica B, 2023, 13(12): 4945-4962. (back cover).
6.Lei Tang#, Wenfang Duan# Chi Zhang#, Yulu Shi, Wenlian, Kangfan Lei, Wenxuan Zhang*, Song Wu*, Jihong Zhang*, Potent salinomycin C20-O-alkyl oxime derivative SAL-98 effciently inhibits tumor growth and metastasis by affecting Wnt/β-catenin signal pathway, Biochemical Pharmacology, 2023, 214, 115666.
7. Qihong Yang #, Tong Qin #, Tao An #, Hongna Wu, Gang Xu, Jin Xiang, Kangfan Lei, Shaohua Zhang, Jie Xia, Guifeng Su, Dan Wang, Minggao Xue, Lingmei Kong, Wenxuan Zhang*, Song Wu*, Yan Li*, Novel PORCN inhibitor WHN-88 targets Wnt/β-catenin pathway and prevents the growth of Wnt-driven cancers, European Journal of Pharmacology, 2023, 945, 175628.
8. Bo Li,# Jun Wu,# Lei Tang,# Xu Lian, Zhongwen Li, Wenfang Duan, Tong Qin, Xintong Zhao, Yuhua Hu, Chi Zhang, Tianlei Li, Jie Hao, Wenxuan Zhang,* Jihong Zhang* and Song Wu*, Synthesis and anti-tumor activity evaluation of salinomycin C20-O-alkyl/benzyl oxime derivatives, Org. Biomol. Chem., 2022, 20, 870.