职 称：研究员、长聘副教授
所属科室：合成药物化学研究室
导师类别：博士生导师
联系方式：010-83166211
所属重点实验室：
谭忠平研究员1992年考⼊北京⼤学化学学院，跟随王剑波教授研究“重氮化合物相关的化学转化”等重要有机化学反应及其机理。1997 年取得北京⼤学学⼠学位，2000 年获得北京⼤学硕⼠学位，同年到美国哥伦⽐亚⼤学化学系 Virginia Cornish 教授课题组留学，2005 年获得化学生物学博⼠学位。从 2005 年到 2011 年，在纽约纪念斯隆-凯特琳癌症中⼼Samuel Danishefsky 教授课题组从事博⼠后研究。2011年加入美国科罗拉多⼤学从事独⽴科学研究，2018年加入中国医学科学院北京协和医学院药物研究所合成药物化学研究室。
谭忠平研究员主要从事糖蛋⽩相关研究。 由于难于获得适合⽤于研究的糖蛋⽩分⼦，科学界对这类⽣物⼤分⼦的了解一直非常落后。利⽤优化的化学合成技术，谭忠平研究员探索出了⼀种新的化学生物学策略进⾏糖蛋⽩研究。这个策略的核⼼是在研究中充分考虑和反映糖蛋⽩的多异型体混合物的天然存在形式，从而能够解决以前难以触及的问题。根据这个策略，利⽤化学合成⾼度灵活和精确的优势，通过模拟糖蛋⽩的天然存在形式，谭忠平研究员构建了多个糖蛋⽩异型体的分⼦⽂库。通过逐个⽐较分⼦⽂库内糖蛋⽩异型体的结构和性质，谭忠平研究员在国际上⾸次系统阐述了蛋⽩氧糖基化结构和性能之间的关系，并把它成功地应⽤到了药⽤蛋⽩和酶的糖基化改造中。
1. Wei Hao, Bo Ma, Ziheng Li, Xiaoyu Wang, Xiaopan Gao, Yaohao Li, Bo Qin, Shiying Shang, Sheng Cui*, Zhongping Tan*. Binding of the SARS-CoV-2 Spike Protein to Glycans. Science Bulletin, 2021, 66(12): 1205-1214.
2. Yaohao L, Xiaoyang Guan, Patrick K. Chaffey, Yuan Ruan, Bo Ma, Shiying Shang, Michael E. Himmel, Gregg T. Beckham*, Hai Long*, Zhongping Tan*. Carbohydrate-binding module O-mannosylation alters binding selectivity to cellulose and lignin. Chemical Science, 2020, 11: 9262-9271
3. Erica T. Prates, Xiaoyang Guan, Yaohao Li, Xinfeng Wang, Patrick K. Chaffey, Munir S. Skaf, Michael F. Crowley*, Zhongping Tan*, Gregg T. Beckham*. The impact of O-glycan chemistry on the stability of intrinsically disordered proteins. Chemical Science, 2018, 9:3710-3715.
4. Xiaoyang Guan, Patrick K. Chaffey, Huan Chen, Wei Feng, Xiuli Wei, Liu-Meng Yang, Yuan Ruan, Xinfeng Wang, Yaohao Li, Kimberly B. Barosh, Amy H. Tran, Jaimie Zhu, Wei Liang, Yong-Tang Zheng*, Xu Wang*, Zhongping Tan*. O-GalNAcylation of RANTES improves its properties as a human immunodeficiency virus type 1 entry inhibitor. Biochemistry, 2018, 57 (1): 136-148.
5. Xiaoyang Guan, Patrick K. Chaffey, Xiuli Wei, Daniel R Gulbranson, Yuan Ruan, Xinfeng Wang, Yaohao Li, Yan Ouyang, Liqun Chen, Chen Zeng, Theo N. Koelsch, Amy H. Tran, Wei Liang*, Jingshi Shen*, Zhongping Tan*. Chemically precise glycoengineering improves human insulin. ACS Chemical Biology, 2018,13 (1), 73-81.
6. Patrick K. Chaffey, Xiaoyang Guan, Xinfeng Wang, Yuan Ruan, Yaohao Li, Suzannah G. Miller, Amy H. Tran, Theo N. Koelsch, Lomax F. Pass, Zhongping Tan*. Quantitative effects of O-linked glycans on protein folding. Biochemistry, 2017, 56 (34), 4539-4548.
7. Patrick K. Chaffey, Xiaoyang Guan, Chao Chen, Yuan Ruan, Xinfeng Wang, Amy H. Tran, Theo N. Koelsch, Qiu Cui, Yingang Feng*, Zhongping Tan*. Structural insight into the stabilizing effect of O-glycosylation. Biochemistry, 2017, 56 (23), 2897-2906.
8. Xiaoyang Guan, Patrick K. Chaffey, Chen Zeng, Eric R. Greene, Liqun Chen, Matthew R. Drake, Claire Chen, Ari Groobman, Michael G. Resch, Michael E. Himmel, Gregg T. Beckham*, Zhongping Tan*. Molecular-scale features that govern the effects of O-glycosylation on a carbohydrate-binding module. Chemical Science, 2015, 6:7185-7189.
9. Liqun Chen, Matthew R. Drake, Michael G. Resch, Eric R. Greene, Michael E. Himmel, Patrick K. Chaffey, Gregg T. Beckham*, Zhongping Tan*. Specificity of O-glycosylation in enhancing the stability and cellulose binding affinity of Family 1 carbohydrate-binding modules. Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (21): 7612-7617.
Christina M. Payne, Michael G. Resch, Liqun Chen, Michael F. Crowley, Michael E. Himmel, Larry E. Taylor II, Mats Sandgren, Jerry Ståhlberg, Ingeborg Stals*, Zhongping Tan*, Gregg T. Beckham*, Glycosylated linkers in multi-modular lignocellulose degrading enzymes dynamically bind to cellulose. Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (36) 14646-14651.
Chemical Biology of Glycoproteins. Tan, Z., and Wang L. Royal Society of Chemistry Publishing, London, Print ISBN 978-1-78262-333-5.
1. S.J. Danishefsky, S. Shang, Z. Tan, S. Dong, J. Li, T. Gardella, (2012) Parathyroid hormone analogs, compositions and uses thereof. US20140228293 A1.
2. S.J. Danishefsky, J.D. Warren, J. Chen, B. Wu, G. Chen, Q. Wan, Z. Tan, C. Kan, Y. Yuan, Z. Hua, K. Ranganathan, J.D. Trzupek (2007) Homogeneous erythropoietin and other peptides and proteins, methods and intermediates for their preparation. WO2007120614 A2.
