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科研队伍

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研究员

杨桠楠

职 称:研究员

所属科室:天然药物化学研究室

导师类别:硕士生导师

联系方式:yyn@imm.ac.cn

所属重点实验室:

个人简介

1. 工作经历
(1) 2020.09-至今 中国医学科学院药物研究所 药物化学 研究员
(2) 2014.09-2020.08 中国医学科学院药物研究所 药物化学 副研究员
(3) 2010.08-2014.08 中国医学科学院药物研究所 药物化学 助理研究员
2. 教育背景
(1) 2007.09-2010.07 中国医学科学院药物研究所 药物化学 博士
(2) 2005.09-2007.07 吉林大学 药物化学 硕士
(3) 2001.09-2005.07 吉林大学 药物化学 学士
3. 在研项目
(1) 国家自然科学基金面上项目。项目编号:81673313。
(2) 国家自然科学基金青年基金项目。项目编号:81303207。
(3) 北京市自然科学基金青年基金项目。项目编号:7144227。。
(4) 医科院基本科研业务费青年医学人才奖励项目。项目编号:2018RC350011。
(5) 药用植物功效利用国家重点实验室开放课题。项目编号:201806。
(6) 道地药材国家重点实验室培育基地开放课题。项目编号:GZ20140118。

研究方向

1. 常用中药药效物质基础研究
2. 天然活性成分的发现、结构修饰及全合成
近十年来重点研究常用中药药效物质,选取在抗肿瘤、抗糖尿病、治疗神经退行性疾病以及心脑血管疾病方面具有确切疗效的十余种常用中药,包括大花红景天、牛蒡子、甘草、丹参、地骨皮等,对其化学成分进行了深入的挖掘和研究,利用已构建靶向分离策略,快速、高效、靶向获得结构新颖的活性先导物。针对高活性的先导物进一步对其进行结构修饰以及全合成研究,从而进一步完成成药性评价,为创新药物研发奠定基础。

发表论文


1. Ya-nan Yang, Hui Zhu, Xiang Yuan, Xu Zhang, Zi-ming Feng, Jian-shuang Jiang, Pei-cheng Zhang* Seven new prenylated flavanones from the roots of Sophora flavescens and their anti-proliferative activities. Bioorganic Chemistry 2021, 109, 104716.
2. Zhao-Kun Yin, Zi-Ming Feng, Jian-Shuang Jiang, Xu Zhang, Pei-Cheng Zhang* and Ya-Nan Yang* New diterpenoid quinones derived from Salvia miltiorrhiza and their cytotoxic and neuroprotective activities. RSC Advances, 2020, 10, 14235.
3. Jun Cao, Si-Yuan Shao, Xu Zhang, Xiang Yuan, Zi-Ming Feng, Jian-Shuang Jiang, Ya-Nan Yang* & Pei-Cheng Zhang*. Two new lignans from the fruits of Forsythia suspense. Journal of Asian Natural Products Research, 2020, 22, 418–424.
4. Zhao-Kun Yin, Zi-Ming Feng, Jian-Shuang Jiang, Xu Zhang, Pei-Cheng Zhang* &Ya-Nan Yang*, Two new tanshinone derivatives from the rhizomes of Salvia miltiorrhiza and their antiviral activities. Journal of Asian Natural Products Research, 2020, 22, 24–29.
5. Ya-Nan Yang, Bing Han, Peng-Fei Yang, Zi-Ming Feng, Jian-Shuang Jiang and Pei-Cheng Zhang *. A concise approach for determining the relative configuration of H-7 and H-8 in 8,4′-oxyneolignans by 1H NMR spectroscopy. Organic Chemistry Frontiers, 2019, 6, 886–891.
6. Ya-Nan Yang, Yuan-Yuan Liu, Zi-Ming Feng, Jian-Shuang Jiang, Pei-Cheng Zhang*,Seven new flavonoid glycosides from the roots of Glycyrrhiza uralensis and their biological activities, Seven new flavonoid glycosides from the roots of Glycyrrhiza uralensis and their biological activities, Carbohydrate Research, 2019, 485, 107820.
7. Xujie Wang(#), Fu Liu(#), Juping Yun, Ziming Feng, Jianshuang Jiang, Ya-Nan Yang*, and Peicheng Zhang* Iron-Catalyzed Synthesis of the Hexahydrocyclopenta[c]furan Core and Concise Total Synthesis of Polyflavanostilbene B. Angewandte Chemie International Edition, 2018, 57, 10127–10131.
8. Ya-Nan Yang(#), YawenAn(#), WeiWang, NingDu, JinghuaZhang, Ziming Feng, JianshuangJiang, PeichengZhang*. Nine compounds from the root bark of Lycium chinense and their anti-inflammatory activities. Acta Pharmaceutica Sinica B 2017, 7, 491–495.
9. Jing Xie(#), Ju-ping Yun(#), Ya-Nan Yang(#), Fang Hua, Xiao-wei Zhang, Heng Lin, Xiao-xi Lv, Ke Li, Pei-cheng Zhang*, Zhuo-wei Hu* A novel ECG analog 4-(S)-(2,4,6-trimethylthiobenzyl)-epigallocatechin gallate selectively induces apoptosis of B16-F10 melanoma via activation of autophagy and ROS. Scientific Reports, 2017, 7:42194.
10. Ya-Nan Yang(#), Ya-Wen An(#), Zhi-Lai Zhan, Jing Xie, Jian-Shuang Jiang, Zi-Ming Feng, Fei Ye, and Pei-Cheng Zhang* Nine new compounds from the root bark of Lycium chinense and their a-glucosidase inhibitory activity. RSC Advances, 2017, 7, 805–812.
11. Hui Zhu(#), Ya-Nan Yang(#), Kuo Xu, Jing Xie, Zi-Ming Feng, Jian-Shuang Jiang and Pei-Cheng Zhang*, Sophopterocarpan A, a novel pterocarpine derivative with a benzotetrahydrofuran-fused bicyclo [3.3.1] nonane from Sophora flavescens. Organic & Biomolecular Chemistry, 2017, 15, 5480–5483.
12. Fan Zhang(#), Ya-Nan Yang(#), Zi-Ming Feng, Jian-Shuang Jiang and Pei-Cheng Zhang*. Four new phenylethanoid and flavonoid glycoside dimers from the fruits of Forsythia suspensa and their neuroprotective activities. RSC Advances, 2017, 7, 24963–24969.
13. Bing Han, Xu Zhang, Zi-Ming Feng, Jian-Shuang Jiang, Li Li, Ya-Nan Yang*, Pei-Cheng Zhang* Ligubenzocycloheptanone A, a Novel Tricyclic Butenolide with a 6/7/5 Skeleton from Ligusticum chuanxiong. Scientific Reports, 2016, 6:28783.
14. Ya-Nan Yang(#), Fu-shuang Li(#), Fu Liu, Zi-ming Feng, Jian-shuang Jiang, and Pei-cheng Zhang*. A novel adduct of ECG fused to piceid and four new dimeric stilbene glycosides from Polygonum cuspidatum. RSC Advances, 2016, 6, 60741–60748.
15. Ya-Nan Yang, Hui Zhu, Zhong Chen, Fu Liu, Ya-Wen An, Zi-Ming Feng, Jian-Shuang Jiang, and Pei-Cheng Zhang* NMR Spectroscopic Method for the Assignment of 3,5-Dioxygenated Aromatic Rings in Natural Products. Journal of Natural Products, 2015, 78, 705−711.
16. Fan Zhang(#), Ya-Nan Yang(#), Xiu-Yun Song, Si-Yuan Shao, Zi-Ming Feng, Jian-Shuang Jiang, Li Li, Nai-Hong Chen, and Pei-Cheng Zhang*. Forsythoneosides A−D, Neuroprotective Phenethanoid and Flavone Glycoside Heterodimers from the Fruits of Forsythia suspense. Journal of Natural Products, 2015, 78, 2390–2397.
17. Ya-Nan Yang(#), Xiao-Ying Huang(#), Zi-Ming Feng, Jian-Shuang Jiang, and Pei-Cheng Zhang*. New Butyrolactone Type Lignans from Arctii Fructus and Their Antiinflammatory Activities. Journal of Agricultural and Food Chemistry, 2015, 63, 7958–7966.

专著

专利


1. 张培成; 王晓良; 杨鹏飞; 彭英; 杨桠楠; 王珊; 冯子明; 姜建双; 一类杭白菊提取的化合物、其药物组合物及其在防治神经退行性疾病中的应用, 2021-01-12, 中国, ZL201611204095.4.
2. 张培成; 陈乃宏; 贠菊平; 宋修云; 杨桠楠; 冯子明; 姜建双; 一类黄烷化合物在防治神经退行性疾病中的应用, 2020-02-18, 中国, ZL201410215128.X.
3. 张培成; 叶菲; 杨桠楠; 田金英; 贠菊平; 张晓琳; 冯子明; 黄立伟;姜建双; 李莫涵; 安亚文; 唐冉琪; 一类黄烷化合物,其制备方法及降糖活性,授权日:2019-09-13, 中国, ZL201410215130.7.
4. 张培成; 侯琦; 陈钟; 林明宝; 杨桠楠; 袁绍鹏; 冯子明; 白金叶; 姜建双; A环具有异戊烯基的醌式查尔酮化合物, 制法与抗炎活性, 2019-04-09, 中国, ZL201410218831.6.
5. 张培成; 侯琦; 陈钟; 林明宝; 杨桠楠; 袁绍鹏; 冯子明; 白金叶; 姜建双;一类A环具有甲基的醌式查尔酮化合物, 制法与抗炎活性, 2019-04-09, 中国, ZL201410220017.8.
6. 陈乃宏; 张培成; 宋修云; 张凡; 张挽青; 杨桠楠; 冯子明; 姜建双; 一类来源连翘的化合物, 其制法及在防治帕金森病的应用, 2019-01-01, 中国,ZL201410223754.3.
7. 张培成; 陈乃宏; 张凡; 宋修云; 杨桠楠; 张帅; 冯子明; 姜建双; 一种连翘活性部位的制备及其在防治帕金森病中的应用, 2019-04-23, 中国, ZL201410223825.X.
8. 张培成; 叶菲; 杨桠楠; 田金英; 冯子明; 张晓琳; 姜建双; 陈玲; 刘照振; 贺伊博; 陈钟; 韩静; 刘峻玚; 一种红景天有效部位、其制备方法、其药物组合物及用途, 2016-09-14, 中国, ZL201010587820.7.
9. 叶菲; 张培成; 田金英; 杨桠楠; 张晓琳; 冯子明; 陈玲; 姜建双; 韩静; 刘照振; 李娟; 陈钟; 付健阳; 防治胰岛素抵抗及其相关代谢综合征的中药组合物, 2016-02-24, 中国, ZL201010587797.1.

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