1. 活性天然产物的靶向挖掘、全合成与结构修饰
2. 基于天然产物的创新药物研发

1. Ji-Ping Liao#, Jiang Li#, Wen-Jie Qin, Xiu-Mei Duan, Peng-Fei Wang, Jin-Ying Tian, Xiang Yuan, Pei-Cheng Zhang, Fei Ye, Ya-Nan Yang*, Two racemic pairs of benzo bicyclo[3.3.1]/[4.2.1] nonene stilbenoid dimers from Heterosmilax yunnanensis and structural revision of syagrusin A, Chinese Chemical Letters, doi: https://doi.org/10.1016/j.cclet.2024.110687.
2. Gangsheng Li, Xiang Yuan, Fu Liu, Zhihua Liu, Xujie Wang, Yuanyuan Liu, Yanmin Chen, Tingting Wang, Yanan Yang*, Peicheng Zhang*, Three-step synthesis of flavanostilbenes with a 2-cyclohepten-1-one core by Cu-mediated [5 + 2] cycloaddition/decarboxylation cascade, Chinese Chemical Letters, 2025, 36, 109880.
3. Jichao Zhou#, Yuanyuan Liu#, Xiaoli Wei#, Meng Yuan#, Xu Zhang#, Lingfeng Qin, Bing Cui, Pingping Li, Jing Zhang, Ziming Feng, Jianshuang Jiang, Xiang Yuan, Ruibing Xu, Zhimeng Zhang, Peicheng Zhang*, Xiaowei Zhang*, Yanan Yang*, Glycnsisitin A: A promising bicyclic peptide against heart failure that facilitates TFRC-mediated uptake of iron in cardiomyocytes, Acta Pharmaceutica Sinica B, 2024, 14, 3125-3139.
4. Zhenyuan Li#, Shuying Li#, Zeyu Xing#, Quanchang Gu, Rongrong Du, Jianshuang Jiang, Xiang Yuan, Xu Zhang, Xiaoguang Chen, Nina Xue, Peicheng Zhang*, Jing Jin*, Yanan Yang*, Discovery of Natural Ah Receptor Antagonists from Salvia miltiorrhiza Bunge and Synthesis of Analogs for Tumor Immunotherapy, Journal of Medicinal Chemistry, 2024, 67, 1243-1261.
5. Linghao Zhao, Haiwei Yan, Jianshuang Jiang, Xu Zhang, Xiang Yuan, Yanan Yang*, Peicheng Zhang*, Effective assignment of positional isomers in dimeric shikonin and its analogs by 1H NMR Spectroscopy. Chinese Chemical Letters, 2024, 35, 108863.
6. Rongrong Du#, Ruoyu Wang#, Jichao Zhou#, Huanhuan Gao, Wenjie Qin, Xiumei Duan, Yanan Yang*, Xiaowei Zhang*, Peicheng Zhang*, Heteryunine A, an amidated tryptophan-catechin-spiroketal hybrid with antifibrotic activity from Heterosmilax yunnanensis. Bioorganic Chemistry, 2024, 151, 107618.
7. Ling-Feng Qin#, Huan-Huan Gao#, Xu Zhang, Xiang Yuan, Zi-Ming Feng, Pei-Cheng Zhang, Jian-Shuang Jiang*, Ya-Nan Yang*, Seventeen undescribed iridoid derivatives with anti-inflammatory effects from Hedyotis diffusa and their structure-activity relationships, Phytochemistry, 2024, 217, 113904.
8. Huan-Huan Gao#, Ling-Feng Qin#, Xu Zhang, Xiang Yuan, Zi-Ming Feng, Jian-Shuang Jiang, Pei-Cheng Zhang*, Ya-Nan Yang*, Six new iridoid glycosides from the whole plants of Hedyotis diffusa, Journal of Asian Natural Products Research, 2024, 26, 112–119.
9. Jian-Shuang Jiang#, Quan-chang Gu#, Zi-Ming Feng, Xiang Yuan, Xu Zhang, Pei-Cheng Zhang*, Ya-Nan Yang*, The tanshinones from the plant of Salvia miltiorrhiza, Phytochemistry, 2023, 210, 113673.
10. Quan-Chang Gu#, Xiao-Li Wei#, Qing Ji#, Zi-Ming Feng, Jian-Shuang Jiang, Xu Zhang, Xiang Yuan, Xiao-Wei Zhang*, Pei-Cheng Zhang*, Ya-Nan Yang*, Two dimers generated by lithospermic decarboxylation coupling from Danshen, Bioorganic Chemistry, 2022, 128, 106065.
11. Jian-Shuang Jiang#, Quan-chang Gu#, Zi-Ming Feng, Xiang Yuan, Xu Zhang, Pei-Cheng Zhang*, Ya-Nan Yang*, The phenolic acids from the plant of Salvia miltiorrhiza, Fitoterapia, 2022, 159, 105180.
12. Ya-nan Yang, Hui Zhu, Xiang Yuan, Xu Zhang, Zi-ming Feng, Jian-shuang Jiang, Pei-cheng Zhang* Seven new prenylated flavanones from the roots of Sophora flavescens and their anti-proliferative activities. Bioorganic Chemistry, 2021, 109, 104716.
13. Zhao-Kun Yin, Zhao-Zhen Liu, Xiang Yuan, Zi-Ming Feng, Jian-Shuang Jiang, Xu Zhang, Pei-Cheng Zhang*, Ya-Nan Yang*. Thirteen undescribed diterpenoid quinones derived from the rhizomes of Salvia miltiorrhiza and their anti-tumor activities. Phytochemistry, 2021, 191, 112902.
14. Yuan Meng, Zi-Ming Feng, Jian-Shuang Jiang, Xu Zhang, Pei-Cheng Zhang*, Ya-Nan Yang*, Three new monocyclic monoterpenoid O-glycosides from the roots of Glycyrrhiza uralensis. Journal of Asian Natural Products Research, 2021, 23, 318-324.
15. Zhao-Kun Yin, Zi-Ming Feng, Jian-Shuang Jiang, Xu Zhang, Pei-Cheng Zhang*, Ya-Nan Yang*, New diterpenoid quinones derived from Salvia miltiorrhiza and their cytotoxic and neuroprotective activities. RSC Advances, 2020, 10, 14235.
16. Ya-Nan Yang, Bing Han, Peng-Fei Yang, Zi-Ming Feng, Jian-Shuang Jiang and Pei-Cheng Zhang*, A concise approach for determining the relative configuration of H-7 and H-8 in 8,4′-oxyneolignans by 1H NMR spectroscopy, Organic Chemistry Frontiers, 2019, 6, 886–891.
17. Xujie Wang#, Fu Liu#, Juping Yun, Ziming Feng, Jianshuang Jiang, Yanan Yang*, and Peicheng Zhang*, Iron-Catalyzed Synthesis of the Hexahydrocyclopenta[c]furan Core and Concise Total Synthesis of Polyflavanostilbene B. Angewandte Chemie International Edition, 2018, 57, 10127–10131.