职 称：研究员
所属科室：药物制剂研究室
导师类别：博士生导师
联系方式：13366210276
所属重点实验室：药物传输技术及新型制剂北京市重点实验室；天然药物活性物质与功能国家重点实验室
高钟镐，男，博士，2008年作为国际高端人才被药物研究所人才引进作为药剂学科带头人，担任研究员和博士生导师。作为博士生导师招收北京协和医学院历史上第一届药剂学专业博士研究生，多名博士毕业生荣获“北京市优秀毕业生”称号。主持承担多项课题，包括美国国家卫生院生物工程部癌症协会基金、美国犹他大学基金、国家自然科学基金、北京市自然科学基金重点项目、国家科技部重大新药创制专项基金等。发表论文80多篇，包括SCI论文60余篇，且多篇论文发表于著名期刊，包括ADDR、Journal of the National Cancer Institute、Nano Letters、PNAS、Biomaterials、Small、JCR、Acta Biomaterialia、等。现兼任药学学报（中英文版）编委、国家药物价格评审专家、中国医药生物技术杂志编委，长期担任国际著名期刊的期刊审稿人。
1、肿瘤靶向纳米制剂研究
包括纳米材料的合成，在纳米载体表面定量连接靶向配位体，构建肿瘤微环敏感的靶向纳米制剂等。
2、纳米载体体内成像和治疗研究
构建一种利用超声波(Ultrasound)和核磁共振(MRI)来对肿瘤同时显影和治疗的纳米颗粒。
3、新型基因递送系统研究
开发新型基因递送载体，用于体内递送质粒基因、siRNA等基因药物。
4、提高口服制剂生物利用度的研究
难溶性药物通过增溶和高度分散的方法来增加体内生物利用度。
5、增加蛋白质多肽类药物在体内稳定性和有效性的研究
Effective Oral Delivery of Exenatide-Zn2+ complex through Distal Ileum-Targeted Double Layers Nanocarriers Modified with Deoxycholic Acid and Glycocholic Acid in Diabetes Therapy. YingHan, WeiLiu, Liqing Chen, Xin Xin, Qiming Wang, Xintong Zhang, Mingji Jin, Zhonggao Gao*, Wei Huang*. Biomaterials, 2021: 120944.
Nanomedicine-based combination anticancer therapy between nucleic acids and small-molecular drugs. Wei Huang#, Liqing Chen#, Lin Kang#, Mingji Jin, Ping Sun, Xin Xin, Zhonggao Gao*, You Han Bae. Advanced Drug Delivery Reviews, 2017, 115:82-97.
Bo Fan, Lin Kang, Liqing Chen, Ping Sun, Mingji Jin, Qiming Wang, You Han Bae, Wei Huang*, Zhonggao Gao*. Systemic siRNA Delivery With a Dual pH-Responsive and Tumor-targeted Nanovector for Inhibiting Tumor Growth and Spontaneous Metastasis in Orthotopic Murine Model of Breast Carcinoma. Theranostics, 2017, 7(2):357-376.
Xiao-DanYan, Qi-Ming Wang, Cai Tie, Hong-Tao Jin, Yan-Xing Han, Jin-Lan Zhang, Xiao-MingYu, Qi Hou, Piao-Piao Zhang, Ai-Ping Wang, Pei-Cheng Zhang*, Zhong-Gao Gao*, Jian-Dong Jiang*. Polydatin protects the respiratory system from PM2.5 exposure. Scientific Reports, 2017, 7:40030.
Ping Sun, Wei Huang*, Lin Kang, Mingji Jin, Bo Fan, Hongyan Jin, Qiming Wang, Zhonggao gao*. siRNA-loaded poly(histidine-arginine)6-modifed chitosan nanoparticle with enhanced cell-penetrating and endosomal escape capacities for suppressing breast tumor metastasis. International Journal of Nanomedicine, 2017, 12:3221–3234.
Lin Kang, Bo Fan, Ping Sun, Wei Huang, Mingji Jin, Qiming Wang, Zhonggao Gao*. An effective tumor-targeting strategy utilizing hypoxia-sensitive siRNA delivery system for improved anti-tumor outcome. Acta Biomaterialia, 2016, 44:341-354.
Ping Sun, Wei Huang, Mingji Jin, Qiming Wang, Bo Fan, Lin Kang, Zhonggao gao*. Chitosan-based nanoparticles for survivin targeted siRNA delivery in breast tumor therapy and preventing its metastasis. International Journal of Nanomedicine, 2016,11:4931-4945.
Liqing Chen, Wei Huang*, Zhonggao Gao*, Weishuo Fang, Mingji Jin. Lx2-32c-loaded polymeric micelles with small size for intravenous drug delivery and inhibitory effect on tumor growth and metastasis against clinically associated 4T1 murine breast cancer. International Journal of Nanomedicine, 2016, 11: 5457-5472.
Shan Liu#, Wei Huang#, Mingji Jin, Bo Fan, Guimin Xia, Zhonggao Gao*. Inhibition of murine breast cancer growth and metastasis by survivin-targeted siRNA using disulfide cross-linked linear PEI. European Journal of Pharmaceutical Sciences, 2016, 82:171–182.
Li-qing Chen#, Zhe-ming Zhang#, Wei Huang*, Zhong-gao Gao*, Wei-shuo Fang, Ming-ji Jin, Lian Yu. Inhibiting the proliferation, migration and invasion of triple negative breast cancer cells through anti-tumor human serum albumin nanoparticles loading Aziditaxel as a novel taxane derivative. Pharmazie, 2017, 72(3):152-160.
Lin Kang, Zhonggao Gao*, Wei Huang, Mingji Jin, Qiming Wang. Nanocarrier-mediated co-delivery of chemotherapeutic drugs and gene agents for cancer treatment. Acta Pharmaceutica Sinica B, 2015, 5(3): 169-175.
Qiming Wang, Zhonggao Gao*, Shan Liu, Bo Fan, Lin Kang, Wei Huang, Mingji Jin. Hybrid polymeric micelles based on bioactive polypeptides as pH-responsive delivery systems against melanoma. Biomaterials, 2014, 35(25): 7008-7021.
Shan Liu, Wei Huang, Mingji Jin, Qiming Wang, Ganlin Zhang, Xiaomin Wang, Shuai Shao, Zhonggao Gao*. Efficient gene delivery of alkylated low molecular weight polyethylenimine through gemini surfactant-like effect. International Journal of Nanomedicine, 2014, 9(1): 3567-3581.
Feifei Yang#, Wei Huang#, Yunfei Li, Shan Liu, Mingji Jin, Yuli Wang, Lihua Jia, Zhonggao Gao*. Anti-tumor effects in mice induced by Survivin-targeted siRNA delivered through polysaccharide nanoparticles. Biomaterials, 2013, 34(22): 5689-5699.
Yunfei Li, Mingji Jin, Shuai Shao, Wei Huang, Feifei Yang, Wei Chen, Shenghua Zhang, Guimin Xia, Zhonggao Gao*. Small-sized polymeric micelles incorporating docetaxel suppress distant metastases in the clinically-relevant 4T1 mouse breast cancer model. BMC Cancer, 2014, 14:329.
Mingji Jin, Wei Chen, Wei Huang, Long Rong, Zhonggao Gao*. Preparation of pegylated lumbrokinase and an evaluation of its thrombolytic activity both in vitro and in vivo. Acta Pharmaceutica Sinica B, 2013, 3(2):123-129.
Yunfei Li, Feifei Yang, Wei Chen, Jiaoyang Liu, Wei Huang, Mingji Jin, and Zhonggao Gao*. A Novel Monomethoxy Polyethylene Glycol-Polylactic Acid Polymeric Micelles with Higher Loading Capacity for Docetaxel and Well-Reconstitution Characteristics and Its Anti-metastasis Study. Chem Pharm Bull, 2012, 60(9):1146-1154.
Wei Huang, Ming Lv, Zhong Gao Gao*. Synthesis of polyethylenimine grafted with copolymers of polyethylene glycol and polycaprolactone and its potential for siRNA delivery. Chinese Chemical Letters, 2011, 22(6):749-752.
Zhong Gao Gao, Li Tian, Jun Hu, In Suh Park, You Han Bae. Prevention of Metastasis in a 4T1 Murine Breast Cancer Model by Doxorubicin Carried by Folate Conjugated pH Sensitive Polymeric Micelles. Journal of Controlled Release, 2011, 152: 84-89.
Natalya Rapoport, Kweon-Ho Nam, Roohi Gupta, Zhonggao Gao, Praveena Mohan, Allison Payne, Nick Todd , Xin Liu , Taeho Kim, Jill Shea, Courtney Scaife, Dennis L. Parker, Eun-Kee Jeong, Anne M. Kennedy. Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions. Journal of Controlled Release, 2011,153 (1):4-15.
D. Kim, Z.G. Gao, E.S. Lee, Y.H. Bae. In vivo evaluation of doxorubicin-loaded polymeric micelles targeting folate receptors and early endosomal pH in drug-resistant ovarian cancer. Molecular Pharmaceutics. 2009, 6(5):1353-1362.
Ge Jiang , Yingzhi Jiang, Yuanyuan Shen , Kweon-Ho Nam, Zhonggao Gao*. DNA Loaded Nano particle Reduced Binding and Preferential Extravasation from Tumor Blood Vessel. International Journal of Pharmaceutics, 2009, 369(1-2):155-61.
Microemulsions-An Introduction to Properties and Applications. Zhonggao Gao, Edited by Reza Najjar. InTech Press, Chapter 6: Thermal Revisable Microemulsion for Poorly Water-Soluble Drugs Oral Delivery. Print ISBN:978-953-51-0247-2.
Carrier based drug delivery. V.P. Torchilin, A.N. Lukyanov, Z. Gao, J. Wang, and T.S. Levchenko, Edited by Sönke Svenson. Oxford University Press, Chapter 9: Polymeric Micelles as Targetable Pharmaceutical Carriers. Print ISBN:9780841238398.
Nanobiomaterials Handbook. Zhonggao Gao, Mingji Jin. Edited by Balaji Sitharaman. CRC Press, Chapter 14, Page 1-16: “Multifuntinonal Nanoparticle for Tumor Targeting Thearpy”. Print ISBN: 9781138076525.
一种包载生物大分子药物的口服纳米聚合物靶向递送系统. 高钟镐; 韩颖; 黄伟; 陈丽青. 2019-9-27, 中国发明专利, 201910927139.3.
一种磷脂-聚乙二醇-狂犬病毒衍生肽聚合物，其制备方法及应用. 黄伟; 高钟镐; 韩明峰; 张哲明; 陈丽青. 2018-7-25, 中国发明专利, 201810833188.6.
一种磷脂-聚乙二醇-冰片聚合物，其制备方法及应用. 黄伟; 高钟镐; 孟令玮; 陈丽青. 2018-6-21, 中国发明专利, 201810641691.1
一种胆汁酸修饰的口服纳米粒. 高钟镐;申红艺;金红妍. 2018-8-10, 中国发明专利, 201810262959.0.
一种狂犬病毒糖蛋白衍生肽修饰的脑靶向核酸递送载体及其应用.黄伟; 高钟镐; 张哲明. 2017-4-25, 中国发明专利, ZL201810317197.X。
一种聚乙烯亚胺-b-聚乳酸嵌段共聚物、其制备方法及应用. 高钟镐; 金明姬; 黄伟. 2017-10-27, 中国发明专利, 201711023906.5.
一种治疗阿尔茨海默病的缓释制剂及其制备方法. 王晓良, 高钟镐, 黄伟, 王琰, 黄海洪, 彭英, 辛欣, 郭芳, 冯茹.2017-4-24,中国发明专利, ZL2017102685878
还原敏感性聚乙烯亚胺衍生物，其制备方法及应用. 高钟镐; 柳珊; 黄伟; 杨飞飞; 金明姬. 2015-9-30, 中国发明专利, ZL201410112675.5.
递送药物的pH敏感型聚合物胶束.高钟镐,王启明. 2014-9-29, 中国发明专利, ZL201410515481.X.
一种用于给药或载药的功能性吸管. 吴松, 高钟镐, 黄伟, 刘璇, 陈丽青, 李天磊, 杨庆云, 张驰, 戚燕, 韩遵圣, 张文轩. 2018-12-10, 中国实用新型专利, ZL201822058834.4.
一种用于给药专用吸管的止回阀. 黄伟, 吴松, 高钟镐, 刘璇, 陈丽青, 李天磊. 2018-10-25, 中国实用新型专利, ZL201821728700.2.
