职 称：研究员
所属科室：天然药物化学研究室
导师类别：博士生导师
联系方式：jitf@imm.ac.cn
所属重点实验室：天然药物活性物质与功能国家重点实验室
1.工作经历
2015.10 至今 中国医学科学院&北京协和医学院，药物研究所，研究员
2009.10-2015.09 中国医学科学院&北京协和医学院，药物研究所，副研究员
2012.09-2013.08 新疆维吾尔自治区药物研究所，副主任，副研究员
2003.07-2009.09 中国医学科学院&北京协和医学院，药物研究所，助理研究员
2.教育背景
1999.09-2003.01 中国医学科学院&北京协和医学院药物研究所，理学博士
1996.09-1999.07 中国科学院新疆化学研究所，理学硕士
1992.09-1996.07 新疆师范大学化学系，理学学士
3.在研项目
治疗再生障碍性贫血创新药物---IMM-H025
1、常用传统中药的药效物质基础研究
2、基于活性天然产物的新药研究开发
研究方向是基于传统药物临床应用基础，结合其传统功效，与药理学科合作，以药理活性为导向，采用分离纯化新技术，明确其药效物质基础；进而以药效物质为先导结构和分子模板，针对其骨架结构特点，采取多样化的结构优化策略；研究药效物质药理活性、作用靶标和成药性等规律，进而开发具有抗炎症相关疾病、代谢性疾病和抗肿瘤的创新药物。
1. Effect of Hypericum perforatum L. extract on insulin resistance and lipid metabolic disorder in high-fat-diet induced obese mice, Jin-ying Tian, Rong-ya Tao, Xiao-lin Zhang, Qian Liu, Yi-bo He, Ya-lun Su, Teng-fei Ji*, Fei Ye*, Phytotherapy Research, 29:86-92, 2015.
2. Polycyclic Polyprenylated Acylphloroglucinol Congeners from Hypericum scabrum, Wan Gao, Wei-Zhen Hou, Jun Zhao, Fang Xu, Li Li, Fang Xu, Hua Sun, Jian-Guo Xing, Ying Peng, Xiao-Liang Wang, Teng-Fei Ji* and Zheng-Yi Gu*, J. Nat. Prod., 79 (6):1538–1547, 2016.
3. Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum scabrum, Wan Gao, Jia-Wen Hu, Fang Xu, Chan-Jing Wei, Meng-Jiao Shi, Jun Zhao, Jia-Jia Wang, Bo Zhen, Teng-Fei Ji*,Jian-Guo Xing, Zheng-Yi Gu* and Fang Xu*, Fitoterapia,115: 128-134, 2016.
4. Four new prenylated phloroglucinol derivatives from Hypericum scabrum, Wan Gao, Jia-Wen Hu, Wei-Zhen Hou, Fang Xu, Jun Zhao, Fang Xu, Hua Sun, Jian- Guo Xing,Ying Peng, Xiao-Liang Wang, Teng-Fei Ji*, Li Li*, Zheng-Yi Gu*, Tetrahedron Lett., 57, 2244-2248,2016.
5. Polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum scabrum, Jiawen Hu, Wan Gao, Fang Xu, Canjing Wei, Mengjiao Shi, Hua Sun, Bo Zhen, Jiajia Wang, Tengfei Ji*, Jiandong Jiang*, Bioorg. Med. Chem. Lett., 27(21):4932-4936,2017.
6. Synthesis and antitumor activity of novel substituted uracil-1′(N)-acetic acid ester derivatives of 20(S)-camptothecins,Di-Zao Li, Qiang-Zhe Zhanga, Cun-Ying Wang, Yan-Ling Zhang, Xing-Yu Li, Ji-Tao Huang, Hong-Yan Liu, Zhao-Di Fu, Hua-Xian Song, Jin-Ping Lin, Teng-Fei Ji*, Xian-Dao Pan*, Eur J Med Chem, 125: 1235-1246, 2017.
7. Assessment of in vitro cardio- toxicity of extract fractions and diterpene alkaloids from Aconitum leucostomum Worosch: A short communication, Jihong Nie*, Fang Wang, Tengfei Ji*, Jun Zhao, Feicui Zhao, Journal of Pharmaceutical and Biomedical Analysis, 137:84-89,2017.
8. Hepatoprotective Effects of Nicotiflorin from Nymphaea candida against Concanavalin A - Induced and D-Galactosamine - Induced Liver Injury in Mice, Jun Zhao, Shilei Zhang, Shuping You, Tao Liu*, Fang Xu, Tengfei Ji*, Gu Zhengyi*，Int. J. Mol. Sci., 18(3), 587; doi:10.3390/ijms18030587,2017.
9. 3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase, Wan Li, Jinyi Liu, Weiqi Fu, Xiangjin Zheng, Liwen Ren, Shiwei Liu, Jinhua Wang*, Tengfei Ji* and Guanhua Du*, J Exp Clin Canc Res,37:132,2018.
10. Synthesis and antitumor activities of sinomenine derivatives on rings A and C, Can-Jing Wei, Fang Xu, Meng-Jiao Shi, Jia-Wen Hu, Jia-Jia Wang, Bo Zhen, Xue Wang, Teng-Fei Ji*, Jin-Hua Wang* & Guan-Hua Du*, J Asian Nat Prod Res, 20 (3): 277-291,2018.
11. Methylated Polycyclic Polyprenylated Acylphloroglucinol Derivatives from Hypericum ascyron, Jia-Wen Hu, Meng-Jiao Shi, Jia-Jia Wang, Li Li, Jian-Dong Jiang*, Teng-Fei Ji*， J. Nat. Prod., 81, 2348−2356, 2018.
12. Boscartins L–O: Cembrane-type diterpenoids from the gum resin of Boswellia sacra Flueck., Jiajia Wang, Bo Zhen, Jiawen Hu, Mengjiao Shi, Canjing Wei, Xue Wang, Hua Sun, Tengfei Ji*, Phytochemistry, 163:126–131, 2019.
13. Hyperascyrins L−N, rare methylated polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum ascyron, Bo Zhen, Jia-Wen Hu, Jia-Jia Wang, Meng-Jiao Shi, Li Li, Ren Ci, Jian-Dong Jiang*,Teng-Fei Ji*, J Asian Nat Prod Res, 21( 5):409-418, 2019.
14. 3-O-acetyl-11-keto-β-boswellic acid ameliorated aberrant metabolic landscape and inhibited autophagy in glioblastoma, Wan Li, Liwen Ren, Xiangjin Zheng, Jinyi Liu, Jinhua Wang*, Tengfei Ji*, Guanhua Du*,Acta Pharmaceutica Sinica B, 10(2):301-312, 2020.
15. Preparative isolation of highly polar free radical inhibitor from Floccularia luteovirens using hydrophilic interaction chromatography directed by on-line HPLC-DPPH assay，Jun Dang, Chengbiao Chen, Jianbin Ma, YangZom Dawa, Qi Wang, Yanduo Tao, Qilan Wang*, Tengfei Ji*，Journal of Chromatography B, 1142:122043, 2020.
16. Hyperacmosins E-G, three new homoadamantane-type polyprenylated acylphloroglucinols from Hypericum acmosepalum, Xue Wang, Mengjiao Shi, Jiajia Wang, Xinyue Suo, Haoran Sun, Bo Zhen, Hua Sun, Jianguang Li*, Tengfei Ji*, Fitoterapia, 142 :104535, 2020.
17. Hyperacmosins H-J, three new polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum acmosepalum, Xue Wang, Jia-Jia Wang, Xin-Yue Suo, Hao-Ran Sun, Bo Zhen, Hua Sun, Jian-Guang Li*，Teng-Fei Ji*, J Asian Nat Prod Res, 22(6): 521-530, 2020.
18. Ten undescribed cembrane-type diterpenoids from the gum resin of Boswellia sacra and their biological activities, Jia-Jia Wang, Hao-Ran Sun, Xin-Yue Suo, Xue Wang, Hua Sun, Xiao-Liang Wang, Jian-Dong Jiang*, Teng-Fei Ji*，Phytochemistry, 177:112425, 2020.
19.Hyperterpenoids A and B: Two pairs of unprecedented 6/6/4/6/6 polycyclic cyclobutane meroterpenoids with potent neuroprotective and anti-inflammatory activities from Hypericum beanii, Bo Zhen，Xinyue Suo，Jun Dang，Huilan Yue，Yanduo Tao，Jia-Jia Wang，Li Li，Ming-Bao Lin，Qi Hou，Wei-Ping Wang，Xiao-Liang Wang，Jian-Dong Jiang*,Teng-Fei Ji*，Chinese Chemical Letters, 32:2338-2341, 2021.
20. Hypseudohenrins I−K: three new polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum pseudohenryi, Hao-Ran Sun, Jia-Jia Wang, Bo Zhen, Xue Wang, Xin-Yue Suo,Ming-Bao Lin, Jian-Dong Jiang* and, Teng-Fei Ji*, J Asian Nat Prod Res., 23(06):536-544, 2021.
21. Polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum pseudohenryi, Haoran Sun, Jiajia Wang, Bo Zhen, Xue Wang, Xinyue Suo, Mingbao Lin, Jiandong Jiang*, Tengfei Ji*, Phytochemistry, 178:112761, 2021.
22. Chemoproteomics-based target profiling of sinomenine reveals multiple protein regulators of inflammation, Lian-guo Chen, Hong-jian Wang, Teng-fei Ji*, Chong-Jing Zhang*, Chem. Commun., 57, DOI: 10.1039/ D1CC01522B2021, 2021.
23. Large-scale preparative isolation of bergenin standard substance from Saxifraga atrata using polyamide coupled with micro gel chp20p medium pressure chromatography,Jun Dang, Jianbin Ma, Yurong Du, YangZom Dawa, Qi Wang, Chengbiao Chen, Qilan Wang, Yanduo Tao*, Tengfei Ji*, Journal of Chromatography B,1170 :122617, 2021.
24. Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway, Xiangjin Zheng, Wan Li, Huanli Xu , Jinyi Liu1, Liwen Ren , Yihui Yang , Sha Li, Jinhua Wang*, Tengfei Ji*, Guanhua Du*, Acta Pharmaceutica Sinica B, https://doi.org/10.1016/j.apsb.2021.05.027, 2021.
25. Hyperacmosins K-M, three new polycyclic polyprenylated acylphloroglucinols from Hypericum acmosepalum, Mingxia Sun, Xue Wang, Tingting Zhu, Xinyue Suo, Jiajia Wang, Tengfei Ji*, Bo Liu*, RSC Adv., 11, 21029-21035, DOI: 10.1039/D1RA03533A, 2021.
26. Hyperacmosin N , New Acylphloroglucinol Derivative with Complicated Caged Core from Hypericum acmosepalum, Ming-xia Sun#, Jun Dang#, Ting-ting Zhu#, Xue Wang, Xin-yue Suo, Jia-jia Wang, Teng-fei Ji*, Bo Liu*, Tetrahedron, DOI: https://doi.org/ 10.1016/j.tet.2021.132286, 2021.
27. Structural Revision of Hyperibrin B and Hyperscabrones H and I by Biosynthetic Considerations, NMR, and Chemical Synthesis, Xiaohui Wang, Xiao-Bin Nie, Robert B. Grossman,Teng-Fei Ji*, Xing-Wei Yang*, Journal of Natural Products, https://doi.org/ 10.1021/acs.jnatprod.1c00458, 2021.
28. Prenylaromadendrane-type diterpenoids from the gum resin of Boswellia sacra Flueck and their cytotoxic effects, Jia-Jia Wang, Xin-Yue Suo, Hao-Ran Sun, Xue Wang, Ming-Bao Lin, Jin-Hua Wang*, Jian-Dong Jiang* and Teng-Fei Ji*, Natural Product Research,2022: 36 (21):5400-5406, https://doi.org/ 10.1080/ 14786419. 2021.1939331, 2022.
29. Polycyclic polyprenylated acylphloroglucinols from Hypericum beanii and their hepatoprotective activity,Yonghui Ma, Xinyue Suo, Xiaoxiu Li, Tingting Zhu, Jin Li, Tengfei Ji, Bo Liu, Phytochemistry 203 (2022) 113413, https://doi.org/10.1016/j.phytochem.2022. 113413, 2022.
30. Yisa Wang, Peng Ma, Zijing Wang, Mingxia Sun, Biyu Hou, Tianshu Xu, Wenlan Li, Xiuying Yang, Guanhua Du, Tengfei Ji, Guifen Qiang, Uncovering the effect and mechanism of Panax notoginseng saponins on metabolic syndrome by network pharmacology strategy, Journal of Ethnopharmacology, 300 (2023) 115680, https://doi.org/10.1016/j.jep.2022.115680 , 2023.
