1、常用传统中药的药效物质基础研究
2、基于活性天然产物的新药研究开发
研究方向是基于传统药物临床应用基础，结合其传统功效，与药理学科合作，以药理活性为导向，采用分离纯化新技术，明确其药效物质基础；进而以药效物质为先导结构和分子模板，针对其骨架结构特点，采取多样化的结构优化策略；研究药效物质药理活性、作用靶标和成药性等规律，进而开发具有抗炎症相关疾病、代谢性疾病和抗肿瘤的创新药物。

1. Chenjing Zhao, Yun Zhang, Xinrui Bao, Hexin Gong, Ze Wu, Wenwen Zang, Jinghong Hu, Tengfei Ji*, Zhengqi Dong*, Multicomponent Nanoassembly Integrating Photosensitizer and Astragalus Polysaccharide Adjuvant for Amplified Photoimmunotherapy via Hypoxia Adaptation Disruption, Nano Research, 2026, https://doi.org/10.26599/NR.2026.94908620.
2. Hong Yang, Bin Jiang, Wan Li, Guanhua Du, Fang Xu, Yizhi Zhang, Yihui Yang, Sen Zhang, Wanxin Cao, Xiaoxue Li, Xu Zhang, Tengfei Ji*, Jinhua Wang*, 7l, a structurally modified Sinomenine, exerts dual anti-glioma effects by inhibiting glioblastoma proliferation and inducing necroptosis which further mediates lysosomal cell death, British Journal of Pharmacology, 182(10): 2310-2331,2025.
3. Ziqian Zhang#, Xilian Ma#, Wei Pan, Xiaoshun Li, Yanyan Li, Nan Fang, Xin Yin, Longlong Yang, Qi Hou, Dezhi Yang, Tengfei Ji*, Ruifang zheng*, Mingbao Lin*; A Novel Compound 3a-M1, from Metabolites of Sinomenine Derivative 3a, Exerts Potent Anti-Aplastic Anemia Activity via IP3R/ORAI-Mediated CTL Ferroptosis, Journal of Medicinal Chemistry , 68(9): 9723-9740, 2025.
4. Zijing Wang, Peng Ma, Ping He, Tianshu Xu, Li Zhang, Chunyang Xu, Biyu Hou, XiuyingYang, Guanhua Du, Tengfei Ji*, Guifen Qiang*, Identification of a novel hypoglycemic small molecule, cajaninstilbene acid by rectifying gut microbiota and activating hepatic AMPKα-PPARγ pathway through gut-liver axis, Biomedicine & Pharmacotherapy, 176: 116760, 2024.
5. Lei Li#, Weijing Kan#, Yi Zhang, Tianyi Wang, Tengfei Ji*, Gang Wang*, Jing Du*, Quantitative Proteomics Combined Independent PRM Analysis Reveals the Mitochondrial and Synaptic Mechanism Underlying Norisoboldine’s Antidepressant Effects, Translational psychiatry, 14:400,2024.
6. Tianshu Xu, Ping He, So namWangdu, Chunyang Xu, Biyu Hou, Peng Ma, Zijing Wang, Li Zhang, Guanhua Du, Tsering*, Tengfei Ji*, Guifen Qiang*,Revealing the improvement of diabetes by Si Wei Jiang Huang Tang San through ERK/HIF1αsignaling pathway via network pharmacology, Journal of Ethnopharmacology, 319:117254, 2024.
7. Yisa Wang, Peng Ma, Zijing Wang, Mingxia Sun, Biyu Hou, Tianshu Xu, Wenlan Li, Xiuying Yang, Guanhua Du, Tengfei Ji*, Guifen Qiang*, Uncovering the effect and mechanism of Panax notoginseng saponins on metabolic syndrome by network pharmacology strategy, Journal of Ethnopharmacology, 300:115680, 2023.
8. Ziqian Zhang, Hongjian Wang, Jiqiao Yuan, Xuyu Li, Nan Fang, Mingbao Lin*, Qi Hou*, Tengfei Ji*, Design, synthesis, and pharmacological evaluation of sinomenine derivatives on rings A and C: novel compounds screening for aplastic anemia targeting on cytotoxic T lymphocyte, European Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry, 225: 113791, 2021.
9. Xiaohui Wang, Xiao-Bin Nie, Robert B. Grossman, Teng-Fei Ji*, Xing-Wei Yang*. Structural Revision of Hyperibrin B and Hyperscabrones H and I by Biosynthetic Considerations, NMR, and Chemical Synthesis, Journal of Natural Products, 84(7): 2059-2064, 2021.
10. Xiangjin Zheng, Wan Li, Huanli Xu , Jinyi Liu1, Liwen Ren , Yihui Yang , Sha Li, Jinhua Wang*, Tengfei Ji*, Guanhua Du*. Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway. Acta Pharmaceutica Sinica B, 11(11):3465-3480, 2021.
11. Lian-guo Chen, Hong-jian Wang, Teng-fei Ji*, Chong-Jing Zhang*, Chemoproteomics-based target profiling of sinomenine reveals multiple protein regulators of inflammation. Chem. Commun., 57, 5981-5984, 2021.
12. Bo Zhen，Xinyue Suo，Jun Dang，Huilan Yue，Yanduo Tao，Jia-Jia Wang，Li Li，Ming-Bao Lin，Qi Hou，Wei-Ping Wang,Xiao-Liang Wang, Jian-Dong Jiang*, Teng-Fei Ji*. Hyperterpenoids A and B: Two pairs of unprecedented 6/6/4/6/6 polycyclic cyclobutane meroterpenoids with potent neuroprotective and anti-inflammatory activities from Hypericum beanie. Chinese Chemical Letters, 32:2338-2341, 2021.
13. Wan Li, Liwen Ren, Xiangjin Zheng, Jinyi Liu, Jinhua Wang*, Tengfei Ji*, Guanhua Du*. 3-O-acetyl-11-keto-β-boswellic acid ameliorated aberrant metabolic landscape and inhibited autophagy in glioblastoma. Acta Pharmaceutica Sinica B, 10(2):301-312, 2020.
14. Jia-Jia Wang, Hao-Ran Sun, Xin-Yue Suo, Xue Wang, Hua Sun, Xiao-Liang Wang, Jian-Dong Jiang*, Teng-Fei Ji*. Ten undescribed cembrane-type diterpenoids from the gum resin of Boswellia sacra and their biological activities. Phytochemistry, 177:112425, 2020.
15. Jia-Wen Hu, Meng-Jiao Shi, Jia-Jia Wang, Li Li, Jian-Dong Jiang*, Teng-Fei Ji*. Methylated Polycyclic Polyprenylated Acylphloroglucinol Derivatives from Hypericum ascyron. J. Nat. Prod., 81, 2348-2356, 2018.