本实验室的研究方向为活性天然产物的药物化学与化学生物学。
近年主要从事两个方面的研究：
（1）微管系统特别是以微管-微管相关蛋白互作为靶的小分子发现，以及在肿瘤和神经退行性疾病治疗中的应用；
（2）天然产物及受天然产物启发的化合物库用于新药发现，涉及的药物靶点有代谢性核受体法尼酯X受体和癌基因MYC。

1. Yuntao Ma, Fernando Josa-Prado,# Jacob Nathaniel Essif,# Shuqi Liu,d Shuo Li, Daniel Lucena Agell, Peter YW Chan, Kenneth Goossens, Rafael Hortigüela-Mecerreyes, Ruth Matesanz, Yingjie Wang, Federico Gago, Hongbo Wang, April Risinger, J. Fernando Diaz,* Wei-Shuo Fang.* Modulation of taxane binding to tubulin curved and straight conformations by systematic 3′N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency. European Journal of Medicinal Chemistry 2023, 259: 115668.
2. Andrea E. Prota,* Daniel Lucena-Agell#, Yuntao Ma#, Juan Estévez-Gallego#, Shuo Li, Katja Bargsten, Fernando Josa-Prado, Karl-Heinz Altmann, Natacha Gaillard, Shinji Kamimura, Tobias Mühlethaler, Federico Gago, María A. Oliva, Michel O. Steinmetz, Wei-Shuo Fang,* J. Fernando Díaz.* Structural insight into the stabilization of microtubules by taxanes. Elife 2023, 12: eLife.84791.
3. Shaorong Wang, Yi Huan, Shuaishuai Niu, Hui Cao, Mingyan Yang, Xinyue Zhou, Xuefeng Gao, Xing Wang, Zhufang Shen, Wei-Shuo Fang.* Discovery of 12β-oxygenated oleanolic acid alkyl esters as potent and selective FXR modulators exhibiting hyperglycemia amelioration in vivo. Bioorganic Chemistry 2022, 129: 106203.
4. Ankit Rai, Tianyang Liu, Simon Glauser, Eugene A. Katrukha, Ruddi Rodríguez-García, Wei-Shuo Fang, J. Fernando Díaz, Michel O. Steinmetz, Karl-Heinz Altmann, Lukas C. Kapitein, Carolyn A. Moores, Anna Akhmanova.* Taxanes convert regions of perturbed microtubule growth into rescue sites. Nature Materials 2020, 19(3): 355-365.
5. Yun-Tao Ma, Yanting Yang, Pei Cai, De-Yang Sun, Pedro A. Sánchez-Murcia, Xiao-Ying Zhang, Wen-Qiang Jia, Lei Lei, Mengqi Guo, Federico Gago, Hongbo Wang,* Wei-Shuo Fang.* A Series of Enthalpically Optimized Docetaxel Analogues Exhibiting Enhanced Antitumor Activity and Water Solubility. Journal of Natural Products 2018, 81(3): 524-533.