炎症免疫相关疾病的发病机制研究与创新药物研发

1. Mengyao Hao # , Guodong Tang # , Enjia Zhou , Rong Fu, MingJin Wang, Huimin Jiang, Xiaoguang Chen, Liping Bai, Xiaoxi Lv*, Jing Jin*. S1PR3 Inhibition in alveolar epithelial cells alleviates pulmonary fibrosis by enhancing alveolar barrier function. Respiratory Research, 2025, 27(1):15.
2. Xue Liu#, Yalan Lu#, Qichen Chen#, Minjian Yang, Shize Li, Hanyu Sun, Xiangying Liu, Jingjie Yan, Liangning Li, Nan Xiang, Yan Lu, Qi Geng, Yiqiao Deng, Baolian Wang, Jing Jin*, Hong Zhao, Xiandao Pan, Ahmed Al-Harrasi, Tingting Du*, Wei Song*, Xiaojian Wang. Deep learning-based discovery of tetrahydrocarbazoles as broad-spectrum antitumor agents and click-activated strategy for targeted cancer therapy. Acta Pharmaceutica Sinica B, 2025, 16(1): 406-422.
3. Chunyu Zhang #, Fangfang Lai #, Hang Gong #, Shuying Li, Nan Xiang, Liuyi Que, Nina Xue, Mengyao Hao, Enjia Zhou, Xiaojian Wang*, Taigang Liang*, Jing Jin*. A Novel Dual Bruton’s Tyrosine Kinase/Janus Kinase 3 Inhibitor Wj1113 and its Therapeutic Effects on Rheumatoid Arthritis. MedComm, 2025, 6(7): e70207.
4. Zhaoxin Zhang #, Shuying Li #, Fangfei Li #, Qinyan Shi, Chengyong Tan, Xiaoying Wang, Mi Li, Yunbao Liu*, Jing Jin*, Yong Li*, Shishan Yu*. Meisoindigo Acts as a Molecular Glue to Target PKMYT1 for Degradation in Chronic Myeloid Leukemia Therapy. Advanced science, 2025, 12(21): e2413676.
5. Zhenyuan Li #, Shuying Li #, Zeyu Xing #, Quanchang Gu, Rongrong Du, Jianshuang Jiang, Xiang Yuan, Xu Zhang, Xiaoguang Chen, Nina Xue*, Peicheng Zhang*, Jing Jin*, Yanan Yang*. Discovery of Natural Ah Receptor Antagonists from Salvia miltiorrhiza Bunge and Synthesis of Analogs for Tumor Immunotherapy. Journal of medicinal chemistry. 2024, 67(2): 1243–1261.
6. Mingjin Wang, Weida Wang, Shen You, Zhenyan Hou, Ming Ji, Nina Xue, Tingting Du, Xiaoguang Chen*, Jing Jin*. ACAT1 deficiency in myeloid cells promotes glioblastoma progression by enhancing the accumulation of myeloid-derived suppressor cells. Acta Pharmaceutica Sinica B 2023, 13(12): 4733-4747.
7. Mengyao Hao #, Rong Fu #, Jun Tai #, Zhenhuan Tian #, Xia Yuan, Yang Chen, Mingjin Wang, Huimin Jiang, Ming Ji, Fangfang Lai, Nina Xue, Liping Bai, Yizhun Zhu, Xiaoxi Lv*, Xiaoguang Chen*, Jing Jin*. S1PR1 serves as a viable drug target against pulmonary fibrosis by increasing the integrity of the endothelial barrier of the lung, Acta Pharmaceutica Sinica B, 2023, 13(3): 1110-1127.
8. Yaru Kong #, Mengyao Hao #, Aiping Chen #, Tianxing Yi, Ke Yang, Peng Li, Yi Wang, Pengfei Li, Xinbei Jia, Han Qin, Yuwei Qi, Jie Ji*, Jing Jin*, Qian Hua*, Jun Tai*. SymMap database and TMNP algorithm reveal Huanggui Tongqiao granules for Allergic rhinitis through IFN-mediated, Pharmacological Research, 2022, 185: 106483
9. Xueju Wei #, Yue Huo #, Jingnan Pi #, Yufeng Gao #, Shuan Rao #, Manman He #, Qinglv Wei, Peng Song, Yiying Chen, Dongxu Lu, Wei Song, Junbo Liang, Lingjie Xu, Haixia Wang, Guolin Hong, Yuehong Guo, Yanmin Si, Jiayue Xu, Xiaoshuang Wang, Yanni Ma, Shuyang Yu, Dongling Zou*, Jing Jin*, Fang Wang*, Jia Yu*. METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis, Nature cell biology, 2022, 24(8): 1278–1290.
10. Jingbo Zhang #, Huimin Jiang #, Songwen Lin #, Deyu Wu, Hua Tian, Lin Jiang, Yiman Cui, Jing Jin*, Xiaoguang Chen*, Heng Xu*. Design and Optimization of Thienopyrimidine Derivatives as Potent and Selective PI3Kδ Inhibitors for the Treatment of B-Cell Malignancies, Journal of medicinal chemistry, 2022, 65(11):8011-8028.（共通, SCI IF=7.3）2022.5.24.
11. Fangfang Lai #, Ming Ji #, Lei Huang, Yunchen Wang, Nina Xue, Tingting Du, Kai Dong, Xiaoqing Yao, Jing Jin*, Zhiqiang Feng*, Xiaoguang Chen*. YPD-30, a prodrug of YPD-29B, is an oral small-molecule inhibitor targeting PD-L1 for the treatment of human cancer. Acta Pharm Sin B. 2022, 12(6): 2845-2858.
12. Yi Dong #, Rong Fu #, Jiajing Chen, Kehui Zhang, Ming Ji, Mingjin Wang, Huimin Jiang, Wei Ye, Jinping Hu, Yan Li, Jing Jin *, Xiaoguang Chen *, Heng Xu *. Discovery of Benzocyclic Sulfone Derivatives as Potent CXCR2 Antagonists for Cancer Immunotherapy, Journal of Medicinal Chemistry, 2021, 64(22): 16626-16640.
13. Qiumu Xi #, Mingjin Wang #, Wenqiang Jia, Mingjian Yang, Jinping Hu, Jing Jin*, Xiaoguang Chen *, Dali Yin, Xiaojian Wang *. Design, Synthesis, and Biological Evaluation of Amidobenzimidazole Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists, Journal of medicinal chemistry. 2020 Jan 9;63(1):260-282.