1. 固态化学药物分析表征的新技术新方法研究。
2. 晶型、共晶等适药新物态为特色的创新药物临床前研发。
3. 民族药、海洋药物等特色药研发。
4. 创新药物及先导物的标准物质和物质标准研究。

1. Wen Zhang#, Li Zhang#, Shuo Fu, Rong Yan, Xue Zhang, Junke Song⁎, Yang Lu⁎. Roles of NLRC4 inflammasome in neurological disorders: Mechanisms, implications, and therapeutic potential. Pharmacology & Therapeutics, 2025, 267: 108803. (Q1, IF=12.5）
2. Shuang Li#, Penghui Yuan#, Xinyi Zhang#, Meiru Liu, Dezhi Yang*, Linglei Kong*, Li Zhang*, Yang Lu, Guanhua Du. Revolutionizing sepsis therapy: Machine learning-driven co-crystallization reveals emodin's therapeutic potential. Chinese Chemical Letters, 2026, 37(2):111289. (Q1, IF=8.9)
3. Chang Zhang, Li Zhang*, Dezhi Yang, Henry H.Y. Tong, Yang Lu, Zhengzheng Zhou*. From traditional screening to machine learning facilitated development of pharmaceutical cocrystals. Chinese Chemical Letters, 2026, 37(11): 111828. (Q1, IF=8.9)
4. Meiru Liu#, Yinru Jiang#, Penghui Yuan, Shuang Li, Baoxi Zhang, Xia Zhou, Bin Su, Yifei Xie, Dezhi Yang*, Linglei Kong*, Li Zhang*, Yang Lv, Guanhua Du.Crystal engineering optimizes emodin-tetramethylpyrazine combination: From cocrystal design to in vivo anti-colitis efficacy assessment. International Journal of Pharmaceutics: X, 2025, 10: 100436. (Q1, IF=6.4）
5. YanXiao Jia#, Cheng Xing#, Yifei Xie, Haixiao Lu, Kun Hu, Yuheng Zhou, Dezhi Yang*, Li Zhang*, Yang Lu. Structural and mechanistic investigation of piroxicam-temozolomide and tenoxicam-temozolomide cocrystal formation. Journal of Molecular Structure, 2026, 1354: 144855. （Q2, IF: 4.7）
6. Zimeng Tao, Kun Hu, Baoxi Zhang, Shiying Yang, Dezhi Yang*, Zhehui Zhao*, Li Zhang*, Yang Lu*. Metal-organic frameworks in pharmaceutical research. Pharmaceutical Science Advances, 2025, 3:100096.
7. Shuang Li, Meiru Liu, Dezhi Yang*, Li Zhang*, Yang Lu*, Guanhua Du. Research and Prospects on the Evaluation of Drug Cocrystal Permeability. International Journal of Drug Discovery and Pharmacology, 2025, 4(1): 100005.
8. Zhipeng Wang, Shuang Li, Qi Li, Wenwen Wang, Meiru Liu, Shiying Yang, Li Zhang*, Dezhi Yang*, Guanhua Du, and Yang Lu*. Novel Cocrystal of Daidzein with Piperazine to Optimize the Solubility, Permeability and Bioavailability of Daidzein. Molecules, 2024, 29: 1710. （Q2, IF: 4.927）
9. Qi An †, Cheng Xing †, Zhipeng Wang, Shuang Li, Wenwen Wang, Shiying Yang, Linglei Kong, Dezhi Yang*, Li Zhang*, Guanhua Du, Yang Lu. Metformin-Mediated Improvement in Solubility, Stability, and Permeability of Nonsteroidal Anti-Inflammatory Drugs. Pharmaceutics, 2024, 16(3): 382. (Q1, IF: 6.525）
10. Yeyang Wang, Baoxi Zhang, WenwenWang, Penghui Yuan, Kun Hu, Li Zhang*, Dezhi Yang* ,Yang Lu*, Guanhua Du. Improvement of the Thermal Stability and Aqueous Solubility of Three Matrine Salts Assembled by the Similar Structure Salt Formers[J]. Pharmaceuticals, 2024, 17(1): 94. (JCR Q1, IF: 5.215)