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研究员

黄伟

职 称:研究员

所属科室:药物制剂研究室

导师类别:博士生导师

联系方式:huangwei@imm.ac.cn

所属重点实验室:药物传输技术及新型制剂北京市重点实验室

个人简介

黄伟:博士、研究员、博士生导师、药物制剂室副主任。主要从事药剂学研究工作。2008年毕业于香港中文大学,获博士学位(PhD);曾任香港中文大学医学院研究助理。作为中央第七批援疆干部,于2013年9月至2014年8月间支援新疆药物研究所建设与发展,任药剂室副主任。在药物递送载体、新型释药系统和创新制剂研究方面具有扎实基础和丰富经验。已招收硕士生13人、博士生2人;培养毕业硕士生9人,其中2人获国家奖学金,1人荣获“北京市优秀毕业生”称号。作为负责人,主持项目研究10多项,主要包括北京市自然科学基金、美国中华医学基金会(CMB)基金项目等。作为主要参加人,参研项目20多项,主要包括“重大新药创制”国家科技重大专项、国家自然科学基金等项目。在国内进行了基因递送载体的开拓性研究,率先研制壳聚糖纳米粒基因递送系统。在基因递送载体、纳米释药系统和创新制剂等方面取得重要研究成果,申请专利30多项,获专利授权10多项,发表学术文章60多篇。担任中国实验动物学会屏障医学专业委员会委员、教育部学位中心评审专家、《Pharmaceutics》编委、《Chinese Chemical Letters》青年编委、《Acta Pharmaceutica Sinica B》和《药学学报》青年编委。长期担任20多种国外SCI期刊的审稿专家。多数研究成果发表于知名专业期刊,包括Materials Today、Advanced Drug Delivery Reviews、Advanced Science、Biomaterials、Acta Pharmaceutica Sinica B、ACS Applied Materials & Interfaces、Journal of Nanobiotechnology等。2014年8月,被新疆人民政府授予“第七批中央和国家机关、中央企业优秀援疆干部人才”称号,并荣获个人二等功。

研究方向

智能递药系统、肿瘤靶向制剂、纳米给药系统、基因递送载体、给药新剂型与新技术。

发表论文

(#co-first author, *corresponding author)
1. Yanhong Liu, Hao Wu, Shuangqing Wang, Xintong Zhang, Liming Gong Congcong Xiao, Chenfei Liu, Liqing Chen, Heming Zhao, Chao Liu, Mingji Jin, Zhonggao Gao*, Wei Huang*. Biomimetic multifunctional nanodrugs enable regulating abnormal tumor metabolism and amplifying PDT-induced immunotherapy for synergistically enhanced tumor ablation. Materials Today, 2023, 68:125-147.(影响因子:24.2,中科院1区)
2. Ying Han, Wei Liu, Liqing Chen, Xin Xin, Qiming Wang, Xintong Zhang, MingjiJin, Zhonggao Gao*, Wei Huang*. Effective Oral Delivery of Exenatide-Zn2+ complex through Distal Ileum-Targeted Double Layers Nanocarriers Modified with Deoxycholic Acid and Glycocholic Acid in Diabetes Therapy. Biomaterials, 2021, 275: 120944. (影响因子:15.304,中科院1区)
3. Shuangqing Wang, Yanhong Liu, Qianwen Sun, Bowen Zeng, Chao Liu, Liming Gong, Hao Wu, Liqing Chen, Mingji Jin, Jianpeng Guo, Zhonggao Gao*, Wei Huang*. Triple Cross-linked Dynamic Responsive Hydrogel Loaded with Selenium Nanoparticles for Modulating the Inflammatory Microenvironment via PI3K/Akt/NF-κB and MAPK Signaling Pathways. Advanced Science, 2023, 10(31): 2303167.(影响因子:15.1,中科院1区)
4. Chao Liu#, Wei Liu#, Yanhong Liu, Hongxia Duan, Liqing Chen, Xintong Zhang, Mingji Jin, Minhu Cui, Xiuquan Quan, Libin, Jiachun Hu, Zhonggao Gao*, Yan Wang*, Wei Huang*. Versatile flexible micelles integrating mucosal penetration and intestinal targeting for effectively oral delivery of paclitaxel. Acta Pharmaceutica Sinica B, 2023, 13(8): 3425-3443. (影响因子:14.5,中科院1区)
5. Wei Liu, Ying Han, Xin Xin, Liqing Chen, Yanhong Liu, Chao Liu, Xintong Zhang, Mingji Jin, Jingzhe Jin, Zhonggao Gao*, Wei Huang*. Biomimetic and temporal-controlled nanocarriers with ileum transporter targeting for achieving oral administration of chemotherapeutic drugs. Journal of Nanobiotechnology, 2022, 20: 281. (影响因子:10.2,中科院1区)
6. Zhe-Ao Zhang, Xin Xin, Chao Liu, Yan-hong Liu, Hong-Xia Duan, Ling-ling Qi, Ying-Ying Zhang, He-ming Zhao, Li-Qing Chen, Ming-Ji Jin, Zhong-Gao Gao*, Wei Huang*. Novel brain-targeted nano-micelles for anti-glioma therapy mediated by the ApoE-enriched protein corona in vivo. Journal of Nanobiotechnology, 2021, 19: 453. (影响因子:9.429,中科院1区)
7. Hongxia Duan, Chao Liu, Yan Hou, Yanhong Liu, Zheao Zhang, Heming Zhao, Xin Xin, Wei Liu, Xintong Zhang, Liqing Chen, Mingji Jin, Zhonggao Gao*, Wei Huang*. Sequential Delivery of Quercetin and Paclitaxel for the Fibrotic Tumor Microenvironment Remodeling and Chemotherapy Potentiation via a Dual-Targeting Hybrid Micelle-in-Liposome System. ACS Applied Materials & Interfaces, 2022, 14(8): 10102-10116. (影响因子:9.5,中科院2区)
8. Chao Liu, Hao Wu, Hongxia Duan, Yan Hou, Shuangqing Wang, Yanhong Liu, Xintong Zhang, Heming Zhao, Liming Gong, Hongshuang Wan, Bowen Zeng, Xiuquan Quan, Minhu Cui, Liqing Chen, Mingji Jin, Qiming Wang, Zhonggao Gao*, Wei Huang*. An EGCG-mediated self-assembled micellar complex acts as a bioactive drug carrier. Food Chemistry, 2023, 418:135939. (影响因子:8.8,中科院1区)
9. Bo Fan, Lin Kang, Liqing Chen, Ping Sun, Mingji Jin, Qiming Wang, You Han Bae, Wei Huang*, Zhonggao Gao*. Systemic siRNA delivery with a dual pH-responsive and tumor-targeted nanovector for inhibiting tumor growth and spontaneous metastasis in orthotopic murine model of breast carcinoma. Theranostics, 2017, 7(2):357-376. (影响因子:8.537,中科院1区)
10. Feifei Yang#, Wei Huang#, Yunfei Li, Shan Liu, Mingji Jin, Yuli Wang, Lihua Jia, Zhonggao Gao*. Anti-tumor effects in mice induced by survivin-targeted siRNA delivered through polysaccharide nanoparticles. Biomaterials, 2013, 34(22):5689-5699. (影响因子:8.312,中科院1区)
11. Wei Huang#, Liqing Chen#, Lin Kang#, Mingji Jin, Ping Sun, Xin Xin, Zhonggao Gao*, You Han Bae. Nanomedicine-based combination anticancer therapy between nucleic acids and small-molecular drugs. Advanced Drug Delivery Reviews, 2017, 115:82-97. (影响因子:13.66,中科院1区)
12. Duan Hongxia, Liu Yanhong, Gao Zhonggao, Wei Huang*. Recent advances in drug delivery systems for targeting cancer stem cells. Acta Pharmaceutica Sinica B, 2021, 11: 55-70. (影响因子:14.903,中科院1区)

专著

1. Xin Xin, Wei Huang*. (2023). mRNA-Based Cancer Therapy and Challenges. In: Rezaei, N. (eds) Handbook of Cancer and Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-80962-1_204-1
2. Zhe-Ao Zhang, Wei Huang*. (2023). Immune Checkpoint Therapy: A New Opportunity for Cancer Treatment. In: Rezaei, N. (eds) Handbook of Cancer and Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-80962-1_162-1
3. Hongxia Duan, Wei Huang*. (2023). Tumor Microenvironment and Tumor-Targeted Therapy. In: Rezaei, N. (eds) Handbook of Cancer and Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-80962-1_114-1

专利

1. 一种狂犬病毒糖蛋白衍生肽修饰的脑靶向核酸递送载体及其应用. 发明人:黄伟、高钟镐、张哲明. 中国发明专利:ZL201810317197.X
2. 一种磷脂-聚乙二醇-狂犬病毒衍生肽聚合物,其制备方法及应用. 发明人:黄伟、高钟镐、韩明峰、张哲明、陈丽青. 中国发明专利: ZL201810833188.6
3. 一种磷脂-聚乙二醇-冰片聚合物,其制备方法及应用. 发明人:黄伟、高钟镐、孟令玮、陈丽青. 中国发明专利:ZL201810641691.1
4. 一种包载生物大分子药物的口服纳米聚合物靶向递送系统. 发明人:高钟镐. 韩颖、黄伟、陈丽青. 中国发明专利:ZL2019109271393
5. 还原敏感性聚乙烯亚胺衍生物,其制备方法及应用. 发明人:高钟镐、柳珊、黄伟、杨飞飞、金明姬. 中国发明专利:ZL201410112675.5
6. 一种聚乙烯亚胺-b-聚乳酸嵌段共聚物、其制备方法及应用. 发明人:高钟镐、金明姬、黄伟. 中国发明专利:ZL201811264453.X

科技奖励

1. 2014年8月,被新疆人民政府授予“第七批中央和国家机关、中央企业优秀援疆干部人才”称号,并荣获个人二等功。