2006-2010 西南大学药学专业，获得学士学位
2010-2011 中科院上海有机化学研究所担任研究助理，从事天然产物全合成研究（李昂）
2012-2013 新加坡国立大学担任研究助理，从事不对称催化研究（赵宇）
2013-2018 新加坡国立大学有机化学专业，获得博士学位，从事不对称催化研究（赵宇）
2018-2022 美国Scripps研究所博士后，从事化学酶法合成研究（Hans Renata）
2022-至今 中国医学科学院药物研究所，准长聘助理教授、研究员、博士生导师

化学酶法合成是合成生物学与合成化学的联合应用，将二者的优势特点整合优化。通过酶法转化、化学催化手段实现药物合成中的关键化学键形成和手性中心构建，简化合成路线，提高合成效率，降低生产成本，并且减少反应产生的废弃物，降低污染，创建绿色精准的新型合成模式，为合成路线创新和新药开发提供理想的解决方案。
研究方向包括以下三方面：
1. 通过基因挖掘手段寻找新的酶催化剂，对酶进行改造优化，发展新型酶催化反应；
2. 结合酶催化和化学合成策略制备重要化学中间体，推向活性天然产物和药物分子的合成。
3. 新药发现

1) “Diastereoselective Synthesis of β-Branched α-Amino Acids via Biocatalytic Dynamic Kinetic Resolution,” Li, F.;# Yang, L.-C.;# Zhang, J.; Chen, J. S.; Renata, H.* Angew. Chem., Int. Ed. 2021, 60, 17680-17685. (Co-first author; Featured in Synfacts)
2) “Stereoselective Access to [5.5.0] and [4.4.1] Bicyclic Compounds through Pd-Catalysed Divergent Higher-Order Cycloadditions,” Yang L.-C.;# Wang, Y.-N.;# Liu, R.; Luo, Y.; Ng, X. Q.; Yang, B.; Rong, Z.-Q.; Lan, Y.;* Shao, Z.;* Zhao, Y.* Nat. Chem. 2020, 12, 860-868.
3) “Pd-Titanium Relay Catalysis Enables Switch of Alkoxide-π-Allyl to Dienolate Reactivity for Spiro-Heterocycle Synthesis," Yang, L.-C.; Tan, Z. Y.; Rong, Z.-Q.; Liu, R.; Wang, Y.-N.; Zhao, Y.* Angew. Chem. Int. Ed. 2018, 57, 7860-7864. (Featured in Synfacts)
4) “Pd-Catalyzed Enantioselective [6+4] Cycloaddition of Vinyl Oxetanes with Azadienes to Access Ten-Membered Heterocycles,” Wang, Y.-N.;# Yang L.-C.;# Rong, Z.-Q.; Liu, T.-L.; Liu, R.; Zhao, Y.* Angew. Chem., Int. Ed. 2018, 57, 1596-1600. (Co-first author; featured in Synfacts)
5) “Nine-membered Benzofuran-Fused Heterocycles: Enantioselective Synthesis by Pd-Catalysis and Rearrangement via Transannular Bond Formation” Rong, Z.-Q.;# Yang, L.-C.;# Liu, S.; Yu, Z.; Wang, Y.-N.; Tan, Z. Y.; Huang, R.-Z.; Lan, Y.;* Zhao, Y.* J. Am. Chem. Soc. 2017, 139, 15304-15307. (Co-first author; featured in Synfacts)
6) “Construction of Nine-Membered Heterocycles through Palladium-Catalyzed Formal [5+4] Cycloaddition,” Yang, L.-C.;# Rong, Z.-Q.;# Wang, Y.-N.; Tan, Z. Y.; Wang, M.; Zhao, Y.* Angew. Chem. Int. Ed. 2017, 56, 2927-2931. (Featured in Synfacts; ESI highly cited paper)
7) “Acid-Assisted Ru-Catalyzed Enantioselective Amination of 1,2-Diols through Borrowing Hydrogen,” Yang, L.-C.; Wang, Y.-N.; Zhang, Y.;* Zhao, Y.* ACS Catal., 2017, 7, 93-97. (Featured in Synfacts)
8) “Recent Progress and Developments in Chemoenzymatic and Biocatalytic Dynamic Kinetic Resolution” Yang, L.-C.; Deng, H.; Renata, H. Org. Process Res. Dev. 2022, 26, 1925-1943. (Invited Review)
9) “Ligand Coordination/Dissociation-Induced Divergent Allylic Alkylations Using Alkynes," Huang, Y.; Ma, C.; Liu, S.; Yang, L.-C.; Lan, Y.;* Zhao, Y.* Chem. 2021, 7, 812-826.
10) “Divergent Synthesis of Complex ent-Kauranes, ent-Atisanes and ent-Trachylobanes via a Hybrid Oxidative Approach,” Zhang, X.; King-Smith, E.; Dong, L.-B.; Yang, L.-C.; Rudolf, J. D.; Shen, B.; Renata, H.* Science, 2020, 369, 799-806.
11) “Dynamic Kinetic Asymmetric Amination of Alcohols Assisted by Microwave: Stereo-convergent Access to Tetralin- and Indane-Derived Chiral Amines," Rong, Z.-Q.; Yu, Z.; Weng, C.; Yang, L.-C.; Lu, S.; Lan, Y.;* Zhao, Y.* ACS Catal. 2020, 10, 9464-9475.
12) “Practical, Highly Stereoselective Allyl- and Crotylsilylation of Aldehydes Catalyzed by Readily Available Cinchona Alkaloid Amide," Huang, Y.; Yang, L.; Shao, P.; Zhao, Y.* Chem. Sci. 2013, 4, 3275-3281.