天然药效物质的合成生物学研究。解析重要药源分子或分子群的生物合成途径，揭示关键酶的催化机制；利用酶工程、代谢工程及化学-酶法等技术，建立药效分子的生物制造技术及衍生方法，开展新药创制。

1. Wenlong Zha, Fan Zhang, Jiaqi Shao, Xingmei Ma, Jianxun Zhu, Pinghua Sun, Ruibo Wu*., Jiachen Zi*. Rationally engineering santalene synthase to readjust the component ratio of sandalwood oil. Nature Communications 2022, 13: 2508.
2. Ke Gao, Kangwei Xu, Pengcheng Lin, Jianxun Zhu,* Ruibo Wu,* and Jiachen Zi*. Unexpected Main-Chain-Mediated and Neutral-Intermediate-Involved Catalytic Reaction in a High-Fidelity ent-Neoabietadiene Synthase. ACS Catalysis 2024, 14: 14233−14241.
3. Jianxun Zhu, Tianyue An, Wenlong Zha, Ke Gao, Ting Li, Jiachen Zi*. Manipulation of IME4 expression, a global regulation strategy for metabolic engineering in Saccharomyces cerevisiae. Acta Pharmaceutica Sinica B 2023, 13(6): 2795-2806.
4. Jiazeng Yang, Jincai Liang, Lei Shao, Lihong Liu, Ke Gao, Junliang Zhang, Zhenjiao Sun, Wendong Xu, Pengcheng, Lin, Rongmin Yu, Jiachen Zi*. Green production of silybin and isosilybin by merging metabolic engineering approaches and enzymatic catalysis. Metabolic Engineering 2020, 59: 44-52.
5. Wenlong Zha, Tianyue An, Ting Li, Jianxun Zhu, Ke Gao, Zhenjiao Sun, Wendong Xu, Pengcheng Lin, Jiachen Zi*. Reconstruction of the Biosynthetic Pathway of Santalols under Control of the GAL Regulatory System in Yeast. ACS Synthetic Biology 2020, 9(2): 449-456.
6.Fan Zhang, Tianyue An, Xiaowen Tang, Jiachen Zi*, Hai-Bin Luo*, and Ruibo Wu*. Enzyme Promiscuity versus Fidelity in two Sesquiterpene Cyclases (TEAS versus ATAS). ACS Catalysis 2020, 10: 1470–1484.
7. Jian Chen, Xiaona Fan, Jianhua Zhu, Liyan Song, Zhiwei Li, Fei Lin, Rongmin Yu*, Hanhong Xu*, Jiachen Zi*. Limonoids from seeds of Azadirachta indica A. Juss. and their cytotoxic activity. Acta Pharmaceutica Sinica B 2018, 8(4): 639-644.
8. Jianxun Zhu, Lihong Liu, Maobo Wu, Guiyang Xia, Pengcheng Lin, and Jiachen Zi*. Characterization of a Sesquiterpene Synthase Catalyzing Formation of Cedrol and Two Diastereoisomers of Tricho-Acorenol from Euphorbia fischeriana. Journal of Natural Products 2021, 84, 1780−1786.
9. Jincai Liang, Tianyue An, Jian-Xun Zhu, Shan Chen, Jian-Hua Zhu, Reuben J. Peters, Rongmin Yu, Jiachen Zi*. Mining of the Catharanthus roseus Genome Leads to Identification of a Biosynthetic Gene Cluster for Fungicidal Sesquiterpenes. Journal of Natural Products 2021, 84, 2709−2716.
10. Ke Gao, Ying Lin, Linsheng Li, Wenlong Zha, Jianxun Zhu, and Jiachen Zi*. Characterization of SchTPSs Enables Construction of Yeast for the Bioproduction of α‑Cadinol and the Related Sesquiterpenes. Journal of Agricultural and Food Chemistry. 2023,71, 18424−18430.