扈金萍，博士，研究员，硕士生导师。 2003年-至今于中国医学科学院药物研究所工作，先后任助理研究员、副研究员、研究员，兼任中国药理学会药物代谢专业委员会委员，2009年-2010年作为访问学者于美国纽约州卫生署研修。 工作期间参与完成多个1.1类新药（布格呋喃、IMMH001、IMMH002、MTC-220等）临床前药代动力学研究及临床报批工作。近年来主持或参与国家自然科学基金、北京市科委重点基金，全球结核药物研发联盟，政府间国际科技创新合作重点专项、国家“十一五”“十二五”“十三五”新药重大专项，国家科技部“863项目”、“药代技术平台” 建设等国家级课题15项。到目前为止，发表相关论文60余篇（SCI 50余篇），参与申请专利10项，参与编书2部。

1. 新药药代动力学及PK/PD研究
2. 活性先导物药代特性的早期评价
3. 药物代谢酶/转运蛋白调控的分子机制
4. 天然药物及活性成分对药物代谢酶/转运蛋白调控的生物学效应及构效关系研究
5. 基于药物代谢酶/转运蛋白调节的药物-药物相互作用（DDI）研究

1. Manman Zhao, Jiaqi Mi, Baolian Wang, Qiong Xiao, Yulin Tian, Jinping Hu*, Yan Li*. Insights into the metabolic characteristics of aminopropanediol analogues of SYLs as S1P1 modulators: from structure to metabolism. European Journal of Pharmaceutical Sciences. 2021, 158: 105608
2. Jinping Hu, Jie Zhou, Yanhong Sun, Huixin Tan, Fenghe Wang, Shuainan Liu, Bailing Xu, Yan Li, Zhufang Shen*.Quantitative determination of Cpd118, A novel FBPase inhibitor, in dog plasma by HPLC–MS/MS. Bioanalysis. 2021, 13(11): 865–873.
3. Minwan Hu1, Yang Li1, Feng You, Jie Bai, Xiaoqing Fan, Shengyu Zhao, Yanhong Sun, Baolian Wang*, Jinping Hu*, Yan Li. Comparison and identification of metabolic profiling of bicyclol in rats, dogs and humans in vitro and in vivo. European Journal of Pharmaceutical Sciences. 2020,154:105518
4. Qiong Xiao1, Minwan Hu1, Si Chen, Zeyu Shi, Jinping Hu*, Ping Xie*, Dali Yin*.Design and synthesis of analogues of the sphingosine-1-phosphate receptor 1 agonist IMMH001 with improved phosphorylation rate in human blood. Bioorganic & Medicinal Chemistry. 2020, 28: 115722
5. Xiaoqing Fan, Jie Bai, Minwan Hu, Yanxia Xu , Shengyu Zhao, Yanhong Sun, Baolian Wang, Jinping Hu*, Yan Li. Drug interaction study of flavonoids toward OATP1B1 and their 3D structure activity relationship analysis for predicting hepatoprotective effects. Toxicology. 2020, 437:152445
6. Jie Bai, Li Li, Shengyu Zhao, Xiaoqing Fan, Jie Zhang, Minwan Hu, Yonghui Chen, Yanhong Sun, Baolian Wang, Jing Jin, Xiaojian Wang, Dan Zhang, Jinping Hu*, Yan Li. Heterotropic activation of flavonoids on cytochrome P4503A4: A case example of alleviating dronedarone-induced cytotoxicity. Toxicology Letters. 2020, 319: 187-196.
7. Xiao Q, Hu M, Chen S, Tang Y, Shi Z, Jin J, Hu J*, Xie P*,Yin D*. Design and synthesis of selective sphingosine-1-phosphate receptor 1 agonists with increased phosphorylation rates. Acta Pharmaceutica Sinica B, 2020, 10: 1134-1142.
8. Shengyu Zhao, Rubing Wang, Jie Bai., Xiaoqing Fan, Minwan Hu, Baolian Wang, Jinping Hu*, Yan Li. Simultaneous determination of a promising anti-brain tumor agent CAT3 and its two major metabolites in mouse plasma and brain by a LC-MS/MS method. J Pharm Biomed Anal. 2020, 181: 113106.
9. Xiao Q, Hu M, Chen S, Jin J, Li L, Hu J*, Xie P*,Yin D*. S1P1-selective agonist prodrug IMMH002 is phosphorylated in rats to form an S-configured enantiomer: Synthesis, verification, and biological activity of the in vivo active metabolite. Bioorganic & Medicinal Chemistry Letters, 2020, 30: 127141.
10. Jie Bai, Shengyu Zhao, Xiaoqing Fan, Yonghui Chen, Xiaowen Zou, Minwan Hu, Baolian Wang, Jing Jin, Xiaojian Wang, Jinping Hu*, Dan Zhang*, Yan Li. Inhibitory effects of flavonoids on P-glycoprotein in vitro and in vivo: Food/herb-drug interactions and structure-activity relationships. Toxicology and Applied Pharmacology, 2019, 369: 49-59
11. Xiaoqing Fan, Jie Bai, Shengyu Zhao, Minwan Hu, Yanhong Sun, Baolian Wang, Ming Ji, Jing Jin, Xiaojian Wang, Jinping Hu*,Yan Li. Evaluation of inhibitory effects of flavonoids on breast cancer resistance protein (BCRP):From library screening to biological evaluation to structure-activity relationship[J]. Toxicology in Vitro, 2019, 61: 104642.
12. Jiaqi Mi, Manman Zhao, Shu Yang, Yufei Jia, Yan Wang, Baolian Wang, Jing Jin, Xiaojian Wang, Qiong Xiao, Jinping Hu*, Yan Li*. Identification of cytochrome P450 isoforms involved in the metabolism of Syl930, a selective S1PR1 agonist acting as a potential therapeutic agent for autoimmune encephalitis. Drug Metabolism and Pharmacokinetics. 2017; 32(1):53-60
13. Jiaqi Mi, Manman Zhao, Shu Yang, Shuang Yang, Jing Jin, Xiaojian Wang, Qiong Xiao, Jinping Hu*, Yan Li* Pharmacokinetics of H002, a novel S1PR1 modulator, and its metabolites in rat blood using liquid chromatography–tandem mass spectrometry. Acta Pharmaceutica Sinica B. 2016; 6(6): 576–583
14. Manman Zhao, Jiaqi Mi, Dan Li, Xin Liu, Shuang Yang, Baolian Wang, Li Sheng, Xiaojian Wang, Jing Jin, Jinping Hu*, Yan Li* Quantitative determination of 2-amino-2-(2-(4′-(2- propyloxazol-4-yl)-[1,1-biphenyl]-4-yl)ethyl)propane-1,3-dioland its active phosphorylated metabolite in rat blood by LC–MS/MS and application to PK/PD analysis. Anal Bioanal Chem 2015, 407:7511–7516
15. Hu J, Sheng L, Li L, Zhou X, Xie F, D'Agostino J, Li Y, Ding X. Essential Role of the Cytochrome P450 Enzyme CYP2A5 in Olfactory Mucosal Toxicity of Naphthalene. Drug Metab Dispos. 2014, 42(1): 23-27.
16. Hu J, You F, Yang S, Li Y. Quantitative determination of Lx2-32C, a novel taxane derivative, in rat plasma by liquid chromatography–tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2014,88:483-488.
17. Jin J1, Hu J1, Zhou W, Wang X, Xiao Q, Xue N, Yin D*, Chen X*. Development of a selective S1P1 receptor agonist Syl930, as a potential therapeutic agent for autoimmune encephalitis. Biochem Pharmacol. 2014, 90(1):50-61.

1.《肾脏病学》，王海燕主编，人民卫生出版社，2008年出版。
2.《药理学研究的新思路与新靶点》，陈晓光主编，中国协和医科大学出版社，2012年出版。

1. 双环醇的磷脂复合物及其制备方法，刘玉玲、李燕、李琳、夏学军、王洪亮、陈晖、扈金萍。授权公告日2014/1/15。
2. 13a-（S）去氧娃儿藤宁的盐、其制法和药物组合物与用途，庾石山、陈晓光、吕海宁、李燕（大）、徐嵩、马双刚、刘振佳、张翼、扈金萍。授权公告日 中国：2014/8/20;日本：2015/2/20;欧洲：2017/3/15。
3. 含二苯基噁二唑的羧酸类化合物、其制备方法及医药用途，汪小涧,刘天琪,金晶,扈金萍,陈晓光,尹大力。申请日2017/12/26。
4. (13aS)-3-新戊酰氧基-6,7-二甲氧基菲并吲哚里西啶的晶A型，庾石山,陈晓光,王汝冰,吕海宁,徐嵩,季鸣,李燕,马辰,扈金萍,张婷婷,马双刚,刘云宝，申请日2018/2/5。
5. (13aS)-3-新戊酰氧基-6,7-二甲氧基菲并吲哚里西啶的晶B型，庾石山,陈晓光,王汝冰,吕海宁,徐嵩,季鸣,李燕,马辰,扈金萍,张婷婷,马双刚,刘云宝，申请日2018/2/5。
6. N-酰基磺酰胺盐类FBPase抑制剂、其制备方法、药物组合物及用途，徐柏玲、申竹芳、周洁、刘率男、李燕、李荣翠、崔国楠、盛莉、孙淑娟、扈金萍，申请日2018/12/5。
7. 芳环或芳杂环并咪唑类化合物，其制备方法及制药用途，汪小涧，奚秋牡，金晶，王明晋，贾文强，扈金萍，陈晓光，申请日2019/7/24。
8. 菲并吲哚里西啶生物碱衍生物纳米自乳化组合物及其制备方法，刘玉玲,王洪亮,汪仁芸,夏学军,庾石山,陈晓光,李燕(代谢),王汝冰,季鸣,金晶,扈金萍，申请日2019/7/25。
9. 菲并吲哚里西啶生物碱衍生物固体脂质纳米粒组合物，刘玉玲，王洪亮， 汪仁芸，夏学军，李琳，庾石山，陈晓光，李燕，扈金萍，高丽丽，王汝冰，申请日2019/11/29。
10. 石泽玉、肖琼、彭英、张泳、兰嘉琦、扈金萍、胡民万、尹大力。含5-取代四氢异喹啉的丙酸类化合物、其药物组合物和应用。申请日2020/11/17。