1992年毕业于东北师范大学化学系，获学士学位；1995年毕业于东北师范大学有机化学专业，获硕士学位；1998年毕业于中国医学科学院，中国协和医科大学药物研究所药物化学专业，获博士学位。1998年9月至2000年10月工作于药物研究所，任助理研究员。2000年11月到2003年12月在美国加洲大学戴维斯癌症研究中心和弗吉尼亚理工大学做博士后。2004年2月回到药物所工作，先后任助理研究员、副研究员和研究员。

药物分子设计与合成 针对肿瘤、糖尿病和精神神经系统等疾病领域的生物大分子靶标，整合结构生物学和理性药物分子设计策略，设计合成新结构的小分子化学实体，寻找新机制和新机构的先导结构，开展活性和成药性优化，进行新药创制。

1. Discovery of 2-Ethoxy-5-isobutyramido-N-1-substituted Benzamide Derivatives as Selective Kv2.1 Inhibitors with in Vivo Neuroprotective Effects, Jie Zhou, Weiping Wang, Dong Liu, Shaofeng Xu, Xue Wang, Xinyuan Zhang, Xiaoyu Wang, Yan Li, Li Sheng, Xiaoliang Wang, Bailing Xu, Journal of Medicinal Chemistry, 2024, 67, 213-233.
2. Discovery of Quinazoline-2,4(1H,3H) dione Derivatives Containing a Piperizinone Moiety as Potent PARP-1/2 Inhibitors-Design, Synthesis, in Vivo Antitumor Activity, and X ray Crystal Structure Analysis, Jie Zhou, Tingting Du, Xiaoyu Wang, Haiping Yao, Jialing Deng, Yan Li, Xiaoguang Chen, Li Sheng, Ming Ji, and Bailing Xu, Journal of Medicinal Chemistry, 2023, 66, 14095-14115.
3. An in Silico Investigation of Kv2.1 Potassium Channel: Model Building and Inhibitors Binding Sites Analysis, Xiaoyu Wang, Xinyuan Zhang, Jie Zhou, Weiping Wang, Xiaoliang Wang, and Bailing Xu, Molecular Informatics, 2023, e202300072.
4. Discovery of N Arylsulfonyl-Indole-2-Carboxamide Derivatives as Galectin 3 and Galectin 8 C Terminal Domain Inhibitors, Haoming Zhang, Xiaoyu Wang, Yanjun Wan, Liheng Liu, Jie Zhou, Pingping Li, and Bailing Xu, ACS Medicinal Chemistry Letter, 2023, 14, 1257-1265.
5. Discovery of Novel Indole Derivatives as Fructose-1,6- bisphosphatase Inhibitors and X ray Cocrystal Structures Analysis, Xiaoyu Wang, Rui Zhao, Wenming Ji, Jie Zhou, Quan Liu, Linxiang Zhao, Zhufang Shen, Shuainan Liu, and Bailing Xu, ACS Medicinal Chemistry Letter, 2022, 13, 118-127.
6. Discovery of 3, 6-Disubstituted Isobenzofuran-1(3H)-ones as Novel Inhibitors of Monoamine Oxidases, Kaiyue Liu, Shiqi Zhou, Jie Zhou, Ruxue Bo, Xiaoyu Wang, Tong Xu, Yuhe Yuan, Bailing Xu, Bioorganic & Medicinal Chemistry Letter, 2022, 67, 128748-128755.
7. Discovery of Quinazoline-2,4(1H,3H) dione Derivatives Containing 3-Substituted Piperizines as Potent PARP-1/2 Inhibitors―Design, Synthesis, in Vivo Antitumor Activity, and X ray Crystal Structure Analysis，Jie Zhou, Ming Ji, Xiaoyu Wang, Hailong Zhao, Ran Cao, Jing Jin, Yan Li, Xianhong Chen, Li Sheng, Xiaoguang Chen, and Bailing Xu, Journal of Medicinal Chemistry 2021, 64, 16711-16730.
8. Design, Synthesis and Biological Evaluation of Novel Thiazole-based Derivatives as Human Pin1 Inhibitors, Lifei Du, Xiaoyu Wang, Guonan Cui, Bailing Xu, Bioorganic & Medicinal Chemistry, 2021, 29, 115878-115891.
9. Discovery of N-arylsulfonyl-indole-2-carboxamide Derivatives as Potent, Selective, and Orally Bioavailable Fructose-1,6-Bisphosphatase Inhibitors―Design, Synthesis, in Vivo Glucose Lowering Effects, and X-ray Crystal Complex Analysis, Jie Zhou, Jianbo Bie, Xiaoyu Wang, Quan Liu, Rongcui Li, Hualong Chen, Jinping Hu, Hui Cao, Wenming Ji, Yan Li, Shuainan Liu, Zhufang Shen, Bailing Xu, Journal of Medicinal Chemistry, 2020, 63, 10307-10329.
10. Design, Synthesis and Biological Evaluation of Indole-2-carboxylic Acid Derivatives as IDO1/TDO Dual Inhibitors, Cui Guonan, Lai Fangfang, Wang Xiaoyu, Chen Xiaoguang, Xu Bailing, European Journal of Medicinal Chemistry, 2020, 188, 111985-112005.
11. Discovery of Quinazoline-2,4(1H,3H)-dione Derivatives as Novel PARP1/2 Inhibitors: Design, Synthesis and Their Antitumor Activity, Zhou jie, Ji Ming, Yao Haiping, Cao Ran, Zhao Hailong, Wang Xiaoyu, Chen Xiaoguang, Xu Bailing, Organic & Biomolecilar Chemistry, 2018, 16, 3189-3202.
12. Synthesis and Biological Evaluation of Pyrimidine Derivatives as Novel Pin1 Inhibitors, Cui Guonan, Jin Jing, Chen Hualong, Cao Ran, Chen Xiaoguang, Xu Bailing, Bioorganic & Medicinal Chemistry, 2018, 26, 2186-2197.
13. Discovery of 2-Substituted 1H-Benzo[d]imidazole-4-carboxamide Derivatives as Novel Poly(ADP-ribose)polymerase-1 Inhibitors with in Vivo Anti-tumor Activity, Zhou jie, Ji Ming, Zhu Zhixiang, Cao Ran, Chen Xiaoguang, Xu Bailing, European Journal of Medicinal Chemistry, 2017, 132, 26-41.
14. Discovery of Novel Quinazoline-2,4(1H,3H)-dione Derivatives as Potent PARP-2 Selective Inhibitors, Hailong Zhao, Ming Ji, Guonan Cui, Jie zhou, Fangfang Lai, Xiaoguang Chen, Bailing Xu, Bioorgnic Medicinal Chemistry 2017, 25, 4045-4054.
15. Synthesis and Pin1 Inhibitory Activity of Thiazole Derivatives, Hailong Zhao, Guonan Cui, Jing Jin, Xiaoguang Chen, Bailing Xu, Bioorgnic Medicinal Chemistry 2016, 24, 5911-5920.
16. Discovery of 1-Substituted Benzyl-quinazoline-2,4(1H,3H)-dione Derivatives as Novel Poly(ADP-ribose)polymerase-1 Inhibitors, Haiping Yao, Ming Ji , Zhixiang Zhu, Jie zhou, Ran Cao, Xiaoguang Chen, Bailing Xu, Bioorgnic Medicinal Chemistry 2015, 23, 681-693.
17. Discovery of Novel Indole Derivatives as Allosteric Inhibitors of Fructose-1,6-bisphosphatase, Jianbo Bie, Shuainan Liu, Zhanmei Li, Yongzhao Mu, Bailing Xu, Zhufang Shen, European Journal of Medicinal Chemistry, 2015, 90, 394-405.
18. Design, Synthesis and Biological Evaluation of 7-Nitro-1H-indole-2-carboxylic Acid Derivatives as Allosteric Inhibitors of Fructose-1,6-bisphosphatase, Jianbo Bie, Shuainan Liu, Jie Zhou, Bailing Xu, Zhufang Shen, Bioorgnic Medicinal Chemistry, 2014, 22, 1850-1862.
19. Synthesis and Biological Evaluation of Novel Quinoxalinone-based HIV-1 Reverse Transcriptase Inhibitors, Jie Zhou, Mingyu Ba, Bo Wang, Haibo Zhou, Jianbo Bie, Decai Fu, Yingli Cao, Bailing Xu, Ying Guo, Medicinal Chemistry Communication, 2014, 5, 441-444.
20. Synthesis and Antiproliferative Evaluation of Novel Benzoimidazole-contained Oxazole-bridged Analogs of Combretastatin A-4, Jie Zhou, Jing Jin, Yi Zhang, Yuwen, Yin, Xiaoguang Chen, Bailing Xu, European Journal of Medicinal Chemistry, 2013, 68, 222-232.
21. Synthesis and Biological Evaluation of Novel Human Pin1 Inhibitors with Benzophenone Skeleton, Chang Liu, Jing Jin, Liang Chen, Jie Zhou, Xiaoguang Chen, Decai, Fu, Hongrui Song, Bailing Xu, Bioorgnic Medicinal Chemistry, 2012, 20, 2992-2999.

1. 吲哚类化合物及其制备方法、药物组合物和用途；徐柏玲、陈晓光、崔国楠、来芳芳、周洁、季鸣、王晓宇、杜婷婷、李陵、金晶；专利授权日2022-9-16，专利号：ZL201810453950.8。
2. 芳酰胺类Kv2.1抑制剂及其制备方法、药物组合物和用途；徐柏玲、王晓良、周洁、王伟平、刘东、郭婷婷、王雪、冯楠、陈华龙、徐少锋、李江、王玲；专利授权日：2022-7-22，专利号：ZL 201810307478.7。
3. 喹唑啉酮类PARP-1抑制剂及及其制备方法，药物组合物和用途；徐柏玲、陈晓光、姚海平、季鸣、金晶、周洁、王珂、赵大龙；专利授权日：2022-4-15，专利号：ZL201680080100.7。
4. N-酰基磺酰胺类FBPase抑制剂、其制备方法、药物组合物及用途; 徐柏玲、申竹芳、别建波、穆永钊、刘率男、周洁、李彩娜、曹冉、环弈、孙淑娟；专利授权日：2020-10-9，专利号：ZL 2016 1 0105864.9。
5. 含有哌嗪酮的喹唑啉酮类PARP-1/2抑制剂及其制备方法、药物组合物和用途；徐柏玲、陈晓光、周洁、季鸣、姚海平、周秦；专利授权日：2020-5-7，专利号：ZL201610108263.3。