王琰，博士，研究员，博士生导师，中国医学科学院药物研究所药物代谢研究室主任，“创新药物非临床药物代谢及PK-PD研究”北京市重点实验室主任。
长期从事药物代谢、药代动力学以及肠道菌药物药理学等研究，突出贡献是应用多组学技术创新建立了天然药物（难吸收）与肠道菌相互作用的关键技术并用于实践，阐明了多个天然药物（小檗碱、巴戟天寡糖等）在肠道菌作用下的化学基础及生物学原理。先后牵头国家“863”计划、国家重点研发计划、国家自然科学基金、北京市重点基金、中国医学科学院创新工程等多个项目。迄今，以通讯作者发表SCI影响因子IF >10 或Q1区论文 15 篇（最高影响因子 39.3），其中，近5年发表影响因子IF >10 或Q1区论文 13篇，引用次数超过100次论文（C100 论文）6 篇，高被引（前1%）论文2篇。授权专利 6 项，参与新药6项。指导研究生6人次获国家奖学金，主编国内第一部肠道菌药学专著《肠道菌与药物代谢》。
同时，兼任第12、13届中国药理学会药物代谢专业委员会副主任委员，中国药学会第8、9届药物分析专业委员会副主任委员、北京药理学会第2届药物代谢专业委员会主任委员，《药学学报》及 Acta Pharmaceutica Sinica B（APSB）、《中国药学杂志》、《药物分析杂志》、《中草药》等期刊编委。

主要从事药物代谢、药代动力学及肠道菌药物药理学研究，聚焦在天然药物与肠道菌相互作用及分子机制领域，重点围绕以下几个方面开展：
1）肠道菌与天然药物相互作用关键技术研究及运用；
2）基于肠道菌的天然药物及天然活性成分代谢转化及药代动力学；
3）肠道菌与临床慢病机制研究及个性化治疗；
4）用于结直肠癌早期诊断的多肽探针体内代谢及关键技术研发。基于上述研究，已形成了一个独特的基于肠道菌的药物代谢及药理学研究方向，为全面认知药物“如何奏效”开辟了新途径，尤其是对解释天然药物标本兼治、扶正祛邪赋予了实际的科学内涵，同时对中药异病同治等给出了科学答案。该研究为探索并发现以肠菌为靶点的慢病治疗创新药物提供了强有力的技术支撑，为药物临床转化及个性化治疗提供了有价值的科学证据。

1. Wang Y*, Tong Q, Ma SR, Zhao ZX, Pan LB, Cong L, Han P, Peng R, Yu H, Lin Y, Gao TL, Shou JW, Li XY, Zhang XF, Zhang ZW, Fu J, Wen BY, Yu JB, Cao XT*, Jiang JD*. Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota. Signal Transduct Target Ther. 2021,6(1):1-20.
2. Shu-Rong Ma#, Qian Tong#, Yuan Lin#, Li-Bin Pan#, Jie Fu#, Ran Peng, Xian-Feng Zhang, Zhen-Xiong Zhao, Yang Li, Jin-Bo Yu, Lin Cong, Pei Han, Zheng-Wei Zhang, Hang Yu, Yan Wang*, Jian-Dong Jiang*. Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota. Signal Transduct Target Ther. 2022, 7:207.
3. Libin Pan†, Hang Yu†, Jie Fu†, Jiachun Hu, Hui Xu, Zhengwei Zhang, Mengmeng Bu, Xinyu Yang, Haojian Zhang, Jinyue Lu, Jian-Dong Jiang*, Yan Wang*, Berberine ameliorates chronic kidney disease through inhibiting the production of gut-derived uremic toxins in the gut microbiota. Acta Pharm Sin B., 2023, 13(4):537-1553.
4. Xin-Yu Yang#, Hang Yu#, Jie Fu#, Hui-Hui Guo , Pei Han, Shu-Rong Ma, Li-Bin Pan, Zheng-Wei Zhang, Hui Xu, Jia-Chun Hu, Hao-Jian Zhang, Meng-Meng Bu, Xian-Feng Zhang, Wei Yang, Jing-Yue Wang, Jing-Yu Jin, Hui-Cong Zhang, Dong-Rui Li, Jin-Yue Lu, Yuan Lin*, Jian-Dong Jiang*, Qian Tong*, Yan Wang*. Hydroxyurea ameliorates atherosclerosis in ApoE-/- mice by potentially modulating Niemann-Pick C1-like 1 protein through the gut microbiota. Theranostics. 2022 Nov 14;12(18):7775-7787.
5. Zheng-Wei Zhang, Chun-Sheng Gao, Heng Zhang, Jian Yang, Ya-Ping Wang, Li-Bin, Pan, Hang Yu, Chi-Yu He, Hai-Bin Luo, Zhen-Xiong Zhao, Xin-Bo Zhou, Yu-Li Wang, Jie Fu, Pei Han, Yuhui Dong, Gang Wang, Song Li*, Yan Wang*, Jian-Dong Jiang*, Wu Zhong*. Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota. Acta Pharm Sin B. 2022, 12(8):3298-3312.
6. Han P, Li LS, Wang ZX, Xi L, Yu H, Cong L, Zhang ZW, Fu J, Peng R, Pan LB, Ma SR. Wang XY, Wang HT*, Wang Y*, Sun JL*, Jiang JD*. Multi-Omics Analysis Provides Insight into the Possible Molecular Mechanism of Hay Fever Based on Gut Microbiota. Engineering. 2022 (15) 115-125.
7. Zhen-Xiong Zhao, Jie Fu, Shu-Rong Ma, Ran Peng, Jin-Bo Yu, Lin Cong, Li-Bin Pan, Zuo-Guang Zhang, Hui Tian, Chun-Tao Che, Yan Wang*, Jian-Dong Jiang*. Gut-brain axis metabolic pathway regulates antidepressant efficacy of albiflorin. Theranostics. 2018, 13;8(21):5945-5959.
8. Pan L, Han P, Ma S, Peng R, Wang C, Kong W, Cong L, Fu J, Zhang Z, Yu H, Wang Y*, Jiang J.D*. Abnormal metabolism of gut microbiota reveals the possible molecular mechanism of nephropathy induced by hyperuricemia. Acta Pharm Sin B. 2020,10(2):249-261.
9. Shang J, Ma S, Zang CX, Bao XQ*, Wang Y*, Zhang D*. Gut microbiota mediates the absorption of FLZ, a new drug for Parkinson’s disease treatment. Acta Pharm Sin B. 2021,11(5):1213-1226.
10. Yan Wang*, Qian Tong, Jia-Wen Shou, Zhen-Xiong Zhao, Xiao-Yang Li, Xian-Feng Zhang, Shu-Rong Ma, Chi-Yu He, Bao-Ying Wen, Fang Guo, Jie Fu, Jian-Dong Jiang*. Gut microbiota-mediated personalized treatment of hyperlipidemia using berberine. Theranostics, 2017 June, 7(9): 2443-2451.
11. Zhang HJ, Fu J, Yu H, Xu H, Hu JC, Lu JY, Bu MM, Zhai Z, Wang JY, Ye ML, Zuo HT, Song JY, Zhao Y, Jiang JD*, Wang Y*. Berberine promotes the degradation of phenylacetic acid to prevent thrombosis by modulating gut microbiota. Phytomedicine. 2024 Mar 7;128:155517.
12. Hang Yu#, Baoying Wen#, Min Huang#, Ru Feng#, Libin Pan, Manyi Xu, Hao Lin, Lin Cong, Sen Zhang, Yan Li, Chi-Hin Cho*, Chongjing Zhang*, Xiaoguang Chen*,Yan Wang*. TCP-1, a novel peptide to diagnose early colon cancer. Chinese Chemical Letters. 2024, 35(03): 108235.https://doi.org/10.1016/j.cclet.2023.108235.
13. Hang Yu#, Hui Xu#, Xinyu Yang, Zhengwei Zhang, Jiachun Hu, Jinyue Lu, Jie Fu, Mengmeng Bu, Haojian Zhang, Zhao Zhai, Jingyue Wang, Jiandong Jiang*, Yan Wang*. Gut microbiota-based PK-PD study and molecular mechanism of Specnuezhenide in the treatment of colorectal cancer targeting carboxylesterase. J Pharm Anal. 2023 Sep; 13(9):1024-1040. doi: 10.1016/j.jpha.2023.06.012.
14. Liu C#, Liu W#, Liu Y, Duan H, Chen L, Zhang X, Jin M, Cui M, Quan X, Pan L, Hu J, Gao Z*, Wang Y*, Huang W*. Versatile flexible micelles integrating mucosal penetration and intestinal targeting for effectively oral delivery of paclitaxel. Acta Pharm Sin B. 2023 Aug;13(8):3425-3443. doi: 10.1016/j.apsb.2023.05.029. Epub 2023 May 26.
15. Hui Xu#, Hang Yu#, Jie Fu, Zheng-Wei Zhang, Jia-Chun Hu, Jin-Yue Lu, Xin-Yu Yang,Meng-Meng Bu, Jian-Dong Jiang*, Yan Wang*. Metabolites analysis of plantamajoside based on gut microbiota-drug interaction. Phytomedicine. 2023 Apr 27;116:154841. doi: 10.1016/j.phymed.2023.154841.
16. Zhang ZW, Cong L, Peng R, Han P, Ma SR, Pan LB, Fu J, Yu H, Wang Y*, Jiang JD*. Transformation of Berberine to Its Demethylated Metabolites by the CYP51 Enzyme in the Gut Microbiota. J. Pharm. Anal. Volume 11, Issue 5, October 2021: 628-637.
17. Yan Wang*, Jia-Wen Shou, Xiao-Yang Li, Zhen-Xiong Zhao, Jie Fu, Chi-Yu He, Ru Feng, Chao Ma, Bao-Ying Wen, Fang Guo, Xin-Yi Yang, Yan-Xing Han, Lu-Lu Wang, Qian Tong, Xue-Fu You, Yuan Lin, Wei-Jia Kong, Shu-Yi Si, Jian-Dong Jiang*. Berberine-induced bioactive metabolites of gut microbiota improves energy metabolism. Metabolism-clinical & Experimental, 2017 May, 70, 72–84.
18. Feng R, Zhao ZX, Ma SR, Guo F, Wang Y*, Jiang JD*. Gut microbiota-regulated pharmacokinetics of berberine and active metabolites in beagle dogs after oral administration. Front Pharmacol. 2018 Mar 21;9:214.
19. Ru Feng, Jia-Wen Shou, Zhen-Xiong Zhao, Chi-Yu He, Chao Ma, Min Huang, Jie Fu, Xiang-Shan Tan, Xiao-Yang Li, Bao-Ying Wen, Xi Chen, Xin-Yi Yang, Gang Ren, Yuan Lin, Yangchao Chen, Xue-Fu You, Yan Wang*, Jian-Dong Jiang*. Transforming berberine into its intestine-absorbable form by gut microbiota. Scientific Reports, 2015, nov, 5: 12155.
20. Chi-Yu He, Ru Feng, Yu-Peng Sun, Shi-Feng Chu, Ji Chen, Chao Ma, Jie Fu, Zhen-Xiong Zhao, Min Huang, Jia-Wen Shou, Xiao-Yang Li, Yu-Zhu Wang, Jin- Feng Hu, Yan Wang*, Jun-Tian Zhang*. Simultaneous quantification of ginsenoside Rg1 and its metabolites by high performance liquid chromatography–tandem mass spectrometry: Rg1 excretion in rat bile, urine, and feces. Acta Pharmaceutica Sinica B, 2016, Nov;6(6): 593-599.
21. Xiao-Yang Li, Zhen-Xiong Zhao, Min Huang, Ru Feng, Chi-Yu He, Chao Ma, Shi-Heng Luo, Jie Fu, Bao-Ying Wen, Long Ren, Jia-Wen Shou, Fang Guo, Yangchao Chen, Xin Gao, Yan Wang*, Jian-Dong Jiang*. Effect of berberine on promoting the excretion of cholesterol in high-fat diet-induced hyperlipidemic hamsters. Journal of Translational Medicine, 2015, Aug, 13(1): 278.
22. Yan Wang*, Jia-Wen Shou, Jian-Dong Jiang*. Metabolism of Chinese Materia Medica in gut microbiota and biological effects. Chinese Herbal Medicines, 2015, May, 7(2), 109-115.
23. Xiang-Shan Tan, Jing-Yi Ma, Ru Feng, Chao Ma, Wen-Jing Chen, Yu-Peng Sun, Jie Fu, Min Huang, Chi-Yu He, Jia-Wen Shou, Wen-Yi He, Yan Wang*, Jian-Dong Jiang*. Tissue distribution of Berberine and its metabolites after oral administration in rats. PLoS One, 2013 Nov, 8(10): e77969. doi:10.1371/journal.pone.0077969.
24. 王琰, 蒋建东. 肠道菌介导的PK-PD 新模式: 小檗碱药代动力学引发的思考. 药学学报, 2018, 53 (5): 659 −666.
25. Jing-Yi Ma, Ru Feng, Xiang-Shan Tan, Chao Ma, Jia-Wen Shou, Jie Fu, Min Huang, Chi-Yu He, Shuo-Nan Chen, Zhen-Xiong Zhao, Wen-Yi He, Yan Wang*, Jian-Dong Jiang**. Excretion of berberine and its metabolites in oral administration in rats. Journal of Pharmaceutical Sciences, 2013 Nov, 102(11), 4181-4192.
26. Ming-Na Sun, Jin-Feng Hu, Xiu-Yun Song, Dong-Hui Wu, Ling-Lei Kong, Yu-Peng Sun, Dong-Mei Wang, Yan Wang**, Nai-Hong Chen***, Gang Liu*. Coumarin derivatives protect against ischemic brain injury in rats. European Journal of Medicinal Chemistry, 2013, Sep., 67, 39-53.
27. Min Huang, Wen-Jing Chen, Ying Zhou, Ru Feng, Jie Fu, Jing-Yi Ma, Xiang-Shan Tan, Chi-Yu He ,Qi-Ming Zhang, Wen-Yi He, Yu-Lin Deng, Yu-Kui Zhang, Xian-Feng Zhang, Yan Wang*. Enantiomeric separations of four basic drugs containing N-alkyl groups by a RP-HPLC system using SBE-β-CD as chiral mobile phase additive. Chinese Chemical Letters, 2013 Aug., 24 (9), 840-844.
28. Ru Feng, Xuelin Zhou, Penelope M.Y. Or, Jing-Yi Ma, Xiang-Shan Tan, Jie Fu, Chao Ma , Jian-Gong Shi, Chun-Tao Che, Yan Wang**, John H.K. Yeung*. Enzyme kinetic and molecular docking studies on the metabolic interactions of 1-hydroxy-2, 3, 5-trimethoxy-xanthone, isolated from Halenia elliptica D. Don, with model probe substrates of human cytochrome P450 enzymes. Phytomedicine, 2012 Sep., 19, 1125-1133.
29. Ru Feng, Yi-Ying Zhang, Xi Chen, Yan Wang**, Jian-Gong Shi, Chun-Tao Che, John H.K. Yeung, Jing-Yi Ma, Xiang-Shan Tan, Chen Yang, Yu-Lin Deng, Yu-Kui Zhang. In vitro study on metabolite profiles of bioactive xanthones isolated from Halenia elliptica D. Don by high performance liquid chromatography coupled to ion trap time-of-flight mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 2012 Mar., 62, 228–234.
30. Yan Wang**, Qing-Qiang Yao, Mu-Zou Wang, High performance liquid chromatographic separation of clausenamide enantiomers with chiral–AGP stationary phase，Chinese Chemical Letters, 2010, 21, 860-863.

1. 《肠道菌与药物代谢》，主编，科学出版社，2022年。
2. 《小檗碱》，编委，科学出版社，2018年
3. 《The Chemistry and Biological Activities of (-)-Clasenamide》, 副主编，化学工业出版社，2014
4. 《中草药现代研究》，编委，中国协和医科大学出版社, 2010年

1. 北京市科技新星（2002）
2. 第六届中国科协优秀科技论文遴选计划百篇优秀论文（2021）
3. 北京科学技术协会首都前沿学术成果（2023）
4. 入选《中国2023年度医学重要进展》，为药学领域5项进展之一（2024）