肥胖及代谢性疾病发病新机制、新药靶和原创新药研发。

1. Xingfeng Liu, Jingwen Chen, Shengying Gu, Yibing Chen,Ruiping Zhang, Qingce Zang, Ting Li, Hanwen Li, Dejin Lu,Shaocong Hou, Lijuan Kong, Qian Jiang, Caiyi Xing,Wenjia Fan, YanjunWan, Jiaqi Zhang, Linyuan Zhu, ChunxiaoMa,Qijin Zhao, Hai Yan, Zeper Abliz , Bing Cui * & Pingping Li*. Prolonged glucagon exposure rewires lipid oxidation and drives diabetic kidney disease progression. Nat Commun. 2025 16:8561. (* co-corresponding author)
2. Yibing Chen, Qian Jiang, Xiaowei Xing, Liu Xu, Qijin Zhao, Qidong Zhang, Jingwen Chen,Chunxiao Ma, Xingfeng Liu, Yinfei Lu, Yanjun Wan, Lijuan Kong, Shaocong Hou, Qian Lu,Bing Cui, Jiankan Guo, Hongdong Huang,* and Pingping Li*, Macrophage Derived Galectin-3 Promotes Renal Fibrosis and Diabetic Kidney Disease by Enhancing TGF beta-1 Signaling, Advanced Science, 2025 Sep;12(35):e04032. (* co-corresponding author)
3. Qian Jiang, Qijin Zhao, Pingping Li*. Galectin-3 in metabolic disorders: mechanisms and therapeutic potential. Trends in Molecular Medicine, May 2025, Vol. 31, No. 5.
4. Shaocong Hou, Hengcai Yu, Caihong Liu, Andrew. M. F. Johnson, Xingfeng Liu, Qian Jiang, Qijin Zhao, Lijuan Kong, Yanjun Wan, Xiaowei Xing, Yibing Chen, Jingwen Chen, Qing Wu, Peng Zhang*, Changtao Jiang*, Bing Cui* and Pingping Li*. Intestinal epithelial cell NCoR deficiency ameliorates obesity and metabolic syndrome. Acta Pharmaceutica Sinica B. 2024. (* co-corresponding author)
5. Jiaojiao Yu, Yujin Xiang, Yuzhen Gao, Shan Chang, Ren Kong, Xiaoxi Lv, Jinmei Yu, Yunjie Jin, Chenxi Li, Yiran Ma, Zhenhe Wang, Jichao Zhou, Hongyu Yuan, Shuang Shang, Fang Hua, Xiaowei Zhang, Bing Cui*, Pingping Li*. PKCα inhibitors promote breast cancer immune evasion by maintaining PD-L1 stability. Acta Pharmaceutica Sinica B. 2024;14(10):4378e4395. (* co-corresponding author)
6. Yibing Chen, Qian Jiang, Xiaowei Xing, Tao Yuan*, Pingping Li*. Clinical research progress on beta-cell dysfunction in T2DM development in the Chinese population. Reviews in Endocrine and Metabolic Disorders. 2024. (* co-corresponding author)
7. Qian Jiang, Qijin Zhao, Yibing Chen, Chunxiao Ma, Xiaohong Peng, Xi Wu, Xingfeng Liu, Ruoran Wang, Shaocong Hou, Lijuan Kong, Yanjun Wan, Shusen Wang, Zhuo-Xian Meng, Bing Cui, Liangyi Chen & Pingping Li*. Galectin-3 impairs calcium transients and beta-cell function. Nat Commun. 2024 May 1;15(1):3682.
8. Lijuan Kong , Qijin Zhao, Xiaojing Jiang, Jinping Hu, Qian Jiang, Li Sheng, Xiaohong Peng, Shusen Wang, Yibing Chen, Yanjun Wan, Shaocong Hou , Xingfeng Liu，Chunxiao Ma, Yan Li, Li Quan, Liangyi Chen, Bing Cui & Pingping Li*. Trimethylamine N-oxide impairs beta-cell function and glucose tolerance. Nat Commun. 2024 Mar 21;15(1):2526.
9. Lijuan Kong, Pingping Li*. Gut Microbiota Metabolite Trimethylamine N-oxide Reduced Pancreatic beta Cell Calcium Transients and Function. Archives of Molecular Biology and Genetics. 2024; 3(1): 1-4.
10. Xingfeng Liu, Kai Wang, Shaocong Hou, Qian Jiang, Chunxiao Ma, Qijin Zhao, Lijuan Kong, Jingwen Chen, Zhenhe Wang, Huabing Zhang, Tao Yuan, Yuxiu Li, Yi Huan, Zhufang Shen, Zhuowei Hu, Zhifeng Huang, Bing Cui and Pingping Li*. Insulin induces insulin receptor degradation in the liver through EphB4. Nature Metabolism. 2022, 4(9):1202-1213.
11. Xingfeng Liu, Kai Wang, Luhai Wang, Lijuan Kong, Shaocong Hou, Yanjun Wan, Chunxiao Ma, Jingwen Chen, Xiaowei Xing, Caiyi Xing, Qian Jiang, Qijin Zhao, Bing Cui, Zhifeng Huang*, Pingping Li*. Hepatocyte leukotriene B4 receptor 1 promotes NAFLD development in obesity. Hepatology. 2022, doi: 10.1002/hep.32708. Online ahead of print. (* co-corresponding author) PMID: 35931467
12. Lei Ying, Luyao Wang, Kaiwen Guo, Yushu Hou, Na Li, Shuyi Wang, Xingfeng Liu, Qijin Zhao, Jie Zhou, Longwei Zhao, Jianlou Niu, Chuchu Chen, Lintao Song, Shaocong Hou, Lijuan Kong, Xiaokun Li, Jun Ren, Pingping Li*, Moosa Mohammadi* & Zhifeng Huang*. Paracrine FGFs target skeletal muscle to exert potent anti-hyperglycemic effects. Nature Communications. 2021,12:7256. (* co-corresponding author) PMID: 34907199
13. Johnson, A. M. F., Shaocong Hou, & Pingping Li*. Inflammation and insulin resistance: New targets encourage new thinking: Galectin-3 and LTB4 are pro-inflammatory molecules that can be targeted to restore insulin sensitivity. Bioessays. 2017, 39 (9). PMID: 28752547
14. Pingping Li*, Shuainan Liu, Min Lu, Gautum Bandyopadhyay, Dayoung Oh, Takeshi Imamura, Andrew M.F. Johnson, Dorothy Sears, Zhufang Shen, Bing Cui, Lijuan Kong, Shaocong Hou, Xiao Liang, Salvatore Iovino, Steven M. Watkins, Wei Ying, Olivia Osborn, Joshua Wollam, Martin Brenner, and Jerrold M. Olefsky *. Hematopoietic-derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Cell 2016. 167(4):973-984.e12 (Lead Contact, * co-corresponding author) PMID: 27814523
15. Pingping Li*, Da Young Oh, Gautam Bandyopadhyay, William S Lagakos, Saswata Talukdar, Olivia Osborn, Andrew Johnson, Heekyung Chung, Rafael Mayoral, Michael Maris, Jachelle M Ofrecio, Sayaka Taguchi, Min Lu & Jerrold M Olefsky*. LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes. Nat Med. 2015; 21(3): 239-47. (* co-corresponding author) PMID: 25706874.
16. Pingping Li*, Nathanael J. Spann*, Minna U. Kaikkonen, Min Lu, Da Young Oh, Jesse N. Fox, Gautam Bandyopadhyay, Saswata Talukdar, Jianfeng Xu, William S. Lagakos, David Patsouris, Aaron Armando, Oswald Quehenberger, Edward A. Dennis, Steven M. Watkins, Johan Auwerx, Christopher K. Glass, and Jerrold M. Olefsky. NCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids. Cell 2013; 155, 200-214. (* co-first author) PMID: 24074869
17. Bernat Baeza-Raja*, Pingping Li*, Natacha Le Moan, Benjamin D Sachs, Christian Schachtrup, Dimitrios Davalos, Eirini Vagena, Dave Bridges, Choel Kim, Alan R Saltiel, Jerrold M Olefsky, Katerina Akassoglou. p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. Proc Natl Acad Sci U S A 2012; 109(15):5838-43 (* co-first author) PMID: 22460790
18. Pingping Li, Wuqiang Fan, Jianfeng Xu, Min Lu, Hiroyasu Yamamoto, Johan Auwerx, Dorothy D Sears, Saswata Talukdar, DaYoung Oh, Ai Chen, Gautam Bandyopadhyay, Miriam Scadeng, Jachelle M Ofrecio, Sarah Nalbandian, Jerrold M Olefsky. Adipocyte NCoR knockout decreases PPARgamma phosphorylation and enhances PPARgamma activity and insulin sensitivity. Cell 2011;147:815-826. PMID: 22078880
19. Yun Sok Lee, Pingping Li*, Jin Young Huh, In Jae Hwang, Min Lu, Jong In Kim, Mira Ham, Saswata Talukdar, Ai Chen, Wendell J Lu, Guatam K Bandyopadhyay, Reto Schwendener, Jerrold Olefsky, Jae Bum Kim. Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance. Diabetes 2011;60:2474-2483. (* co-first author). PMID: 21911747
20. Pingping Li, Min Lu, M T Audrey Nguyen, Eun Ju Bae, Justin Chapman, Daorong Feng, Meredith Hawkins, Jeffrey E Pessin, Dorothy D Sears, Anh-Khoi Nguyen, Arezou Amidi, Steven M Watkins, UyenThao Nguyen, Jerrold M Olefsky. Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice. J Biol Chem 2010;285:15333-15345. PMID: 20308074
21. Min Lu, Pingping Li*, Jan Pferdekamper, WuQiang Fan, Maziyar Saberi, Simon Schenk, Jerrold M Olefsky. Inducible nitric oxide synthase deficiency in myeloid cells does not prevent diet-induced insulin resistance. Mol Endocrinol 2010;24:1413-1422. (* co-first author). PMID: 20444886
22. David Patsouris, Pingping Li*, Divya Thapar, Justin Chapman, Jerrold M Olefsky, Jaap G Neels. Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab 2008;8:301-309. (* co-first author). PMID: 18840360
23. Pingping Li, Song Shan, Yue-Teng Chen, Zhi-Qiang Ning, Su-Juan Sun, Quan Liu, Xian-Ping Lu, Ming-Zhi Xie, Zhu-Fang Shen. The PPARalpha/gamma dual agonist chiglitazar improves insulin resistance and dyslipidemia in MSG obese rats. Br J Pharmacol 2006;148:610-618. PMID: 16751799
24. Haoming Zhang, Xiaoyu Wang, Yanjun Wan, Liheng Liu, Jie Zhou, Pingping Li, Bailing Xu. Discovery of N-Arylsulfonyl-Indole-2-Carboxamide Derivatives as Galectin-3 and Galectin-8 C-Terminal Domain Inhibitors. ACS Med Chem Lett. 2023, 14(9): 1257-1265. PMID: 37736168
25. Shuang Shang, Yu-Wei Yang, Fei Chen, Liang Yu, Shuo-Hao Shen, Ke Li, Bing Cui, Xiao-Xi Lv, Cheng Zhang, Chen Yang, Jing Liu, Jiao-Jiao Yu, Xiao-Wei Zhang, Pingping Li, Sheng-Tao Zhu, Hai-Zeng Zhang, Fang Hua*. TRIB3 reduces CD8+ T cell infiltration and induces immune evasion by repressing the STAT1-CXCL10 axis in colorectal cancer. Science Translational Medicine. 2022, 14(626):eabf0992. PMID: 34985967