朱平，研究员，博士生导师，现任药物所生物合成室主任，药物化学系副主任，中国菌物学会副理事长，《药学学报》、《菌物学报》、《中国医药生物技术》、《药学研究》、《菌物研究》杂志编委。
1988年中国协和医科大学微生物药物学专业研究生毕业，之后，在药物所工作至今。1991年-1993年由欧共体资助(Postdoctoral fellowship)在英国诺丁汉大学进修真菌生化及分子生物学。2004年4月-11月，作为访问教授在美国夏维夷大学从事海绵相关微生物生物多样性研究。
研究领域：微生物工程与天然药物合成生物学。研究内容包括：1. 麦角菌、虫草等传统药用真菌生物合成研究； 2. 海绵相关真菌次级代谢产物生物合成研究；3. 植物药用活性成分生物合成研究。
先后主持或参与多项国家自然科学基金、国家“863”项目、 “十一五”~“十三五”科技重大专项重大新药创制、国家重点研发计划“合成生物学”重点专项以及医科院医学与健康科技创新工程等项目。在国内外学术期刊上累计发表学术论文100多篇，包括在Angew. Chem. Int. Ed.( 2024)(IF=16.6)、Nature Plants (2022)(IF=17.4)、Nature Communications (2017)(IF=12.4)、Acta Pharmaceutica Sinica B (2021,2022)(IF=14.9)、Green Chemistry (2023)(封2图片介绍)(IF=11.0)、Green Chemistry (2019)(封底图片介绍) (IF=9.4)、Chinese Chemical Letters (2024)(IF=9.1)、Molecular & Cellular Proteomics (2013) (封面图片介绍)(IF =7.3)、Critical Reviews in Biotechnology (2019)(IF =7.1)、Fungal Diversity (2010)(IF= 5.1) 等国际知名期刊发表的SCI论文。累计授权17项中国专利和10项国际专利，包括美国、日本、欧洲和韩国专利各2项；以色列和加拿大专利各1项。参编著作6部。获得2011年度中国药学会科学技术三等奖1项 (排名第2)、2022年度中国发明协会发明创业奖一等奖1项 (排名第3)、2020年度“北京协和医学院优秀教师”称号。合作发现3ʹ-脱氧腺苷(虫草素)的降血脂功能及其作为AMPK激动剂的作用机制，本所相关科技人员以此为先导物，已研制出新型降血脂药物并完成临床前研究和技术转让；麦角生物碱的研究为相关企业提供了技术支撑(菌种和技术)。

微生物工程与天然药物合成生物学。
研究内容包括：1. 麦角菌、虫草等传统药用真菌生物合成研究；
2. 海绵相关真菌次级代谢产物生物合成研究；
3. 植物药用活性成分生物合成研究。

1) Ye D‡, Shao YZ‡, Li WR‡, Cui ZJ, Gong T, Yang JL, Wang HQ, Dai JG, Feng KP, Ma M, Ma SG*, Liu YB*, Zhu P*, and Yu SS*. Characterization and engineering of two highly paralogous sesquiterpene synthases reveal a regioselective reprotonation switch. Angew. Chem. Int. Ed. 2024, 63 (13), e202315674.
2) Peng Y, Wang Y, Chen TJ, Chen JJ, Yang JL, Gong T*, and Zhu P*. A fungal CYP from Beauveria bassiana with promiscuous steroid hydroxylation capabilities. Chinese Chem. Lett. 2024, 35(5), 108818.
3) Zhou C‡, Chen T‡, Gu A‡,Hu Z, Li Y, Gong T, Chen J, Yang J* and Zhu P*. Combining protein and metabolic engineering to achieve green biosynthesis of 12β-O-Glc-PPD in Saccharomyces cerevisiae. Green Chem., 2023, 25(4): 1356-1367(Inside front cover image from this issue).
4) Peng Y‡, Huan Y‡, Chen JJ, Chen TJ, Lei L, Yang JL, Shen ZF, Gong T* and Zhu P*. Microbial biotransformation to obtain stilbene methylglucoside with GPR119 agonistic activity. Front. Microbiol. 2023,14:1148513.
5) Huang X‡, Wang W‡, Gong T‡, Wickell D‡, ... Wei H*, Zhu P*, Li FW*, Ming R* and Li, Q*. The flying spider-monkey tree fern genome provides insights into fern evolution and arborescence. Nat. Plants, 2022, 8(5), 500-512.
6) Jiang F, Zhou C, Li Y, Deng H, Gong T, Chen J, Chen T, Yang J*, and Zhu P*. Metabolic engineering of yeasts for green and sustainable production of bioactive ginsenosides F2 and 3β,20S-Di-O-Glc-DM. Acta Pharm. Sin. B. 2022, 12(7):3167-3176.
7) Zhou GL, Li Y, Pei F, Gong T, Chen TJ, Chen JJ, Yang JL, Li QH*, Yu SS*, and Zhu P*. Chromosome-scale genome assembly of Rhododendron molle provides insights into its evolution and terpenoid biosynthesis. BMC Plant Biol., 2022, 22, 342.
8) Qiao YM, Wen YH, Gong T, Chen JJ, Chen TJ, Yang JL, and Zhu P*. Improving ergometrine production by easO and easP knockout in Claviceps paspali. Fermentation, 2022, 8, 263.
9) Wen YH, Chen TJ, Jiang LY, Li L, Guo M, Peng Y, Chen JJ, Pei F, Yang JL, Wang RS, Gong T*, and Zhu P*. Unusual (2R,6R)-bicyclo[3.1.1]heptane ring construction in fungal α- trans-bergamotene biosynthesis. iScience, 2022, 25(4):104030.
10) Wang H‡, Zhang BY‡, Gong T, Chen TJ, Chen JJ, Yang JL, and Zhu P*. Construction of acetyl-CoA and DBAT hybrid metabolic pathway for acetylation of 10-deacetylbaccatin III to baccatin III. Acta Pharm. Sin. B, 2021, 11(10):3322-3334.
11) Yang L‡, Chen TJ‡, Wang F, Li L, Yu WB, Si YK, Chen JJ, Liu WC, Zhu P*, and Gong W*. Structures of β-glycosidase LXYL-P1-2 reveals the product binding state of GH3 family and a specific pocket for Taxol recognition. Commun Biol. 2020, 3(1), 22.
12) Zhou GL, Zhu P*. De novo transcriptome sequencing of Rhododendron molle and identification of genes involved in the biosynthesis of secondary metabolites. BMC Plant Biol. 2020, 20(1), 414.
13) Hu ZF‡, Gu AD‡, Liang L, Li Y, Gong T, Chen JJ, Chen TJ, Yang JL*, and Zhu P*. Construction and optimization of microbial cell factories for the sustainable production of bioactive dammarenediol-II glucosides. Green Chem. 2019, 219(12), 3286-3299 (Back cover image of this issue).
14) Chen JJ, Liang X, Wang F, Wen YH, Chen TJ, Liu WC, Gong T, Yang JL, and Zhu P*. Combinatorial mutation on the β-glycosidase specific to 7-β-xylosyltaxanes and increasing the mutated enzyme production by engineering the recombinant yeast. Acta Pharm. Sin. B 2019, 9(3), 626-638.
15) Liu WC, Inwood S, Gong, Sharma A, Yu LY*, and Zhu P*. Fed-batch high-cell-density fermentation strategies for Pichia pastoris growth and production. Crit. Rev. Biotechnol. 2019, 39(2), 258-271.
16) Zhen X‡, Gong T‡, Wen YH, Yan DJ, Chen JJ, and Zhu P*. Chrysoxanthones A–C, three new xanthone–chromanone heterdimers from sponge-associated Penicillium chrysogenum HLS111 treated with histone deacetylase inhibitor. Mar. Drugs 2018, 16, 357.
17) Gong T, Zhen X, Li XL, Chen JJ, Chen TJ, Yang JL, and Zhu P*. Tetrocarcin Q, a New spirotetronate with a unique glycosyl group from a marine-derived actinomycete Micromonospora carbonacea LS276. Mar. Drugs 2018, 16, 74.
18) Li BJ, Wang H, Gong T, Chen JJ, Chen TJ, Yang JL, and Zhu P*. Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production. Nat. Commun. 2017, 8, 15544.
19) Liu WC, Gong T, Wang QH, Liang X, Chen JJ, and Zhu P*. Scaling-up fermentation of Pichia pastoris to demonstration-scale using new methanol-feeding strategy and increased air pressure instead of pure oxygen supplement. Sci. Rep. 2016, 6,18439.
20) Zhen X‡, Gong T‡, Liu F, Zhang PC, Zhou WQ, Li Y, and Zhu P*. A new analogue of echinomycin and a new cyclic dipeptide from a marine-derived Streptomyces sp. LS298. Mar. Drugs, 2015, 13(11), 6947-6961.
21) Liu WC, Zhu P*. Pilot studies on scale‑up biocatalysis of 7‑β‑xylosyl‑10‑deacetyltaxol and its analogues by an engineered yeast. J. Ind. Microbiol. Biotechnol. 2015, 42, 867-876.
22) Wu C, Guo Y, Su Y, Zhang X, Luan H, Zhang X, Zhu H, He H, Wang X, Sun G, Sun X, Guo P*, and Zhu P*. Cordycepin activates AMP-activated protein kinase (AMPK) via interaction with the γ1 subunit. J. Cell. Mol. Med. 2014, 18(2), 293-304.
23) Chen HL, Zhao RY, Chen TJ, Yu WB, Wang F, Cheng KD, and Zhu P*. Cloning and characterization of the glycoside hydrolases that remove xylosyl group from 7-β-xylosyl-10-deacetyltaxol and its analogues. Mol. Cell. Proteomics. 2013,12(8), 2236-2248 (Cover image and the highlight of this issue).
24) Yu WB, Liang X, and Zhu P*. High-cell-density fermentation and pilot-scale biocatalytic studies of an engineered yeast expressing the heterologous glycoside hydrolase of 7-β-xylosyltaxanes. J. Ind. Microbiol. Biotechnol. 2013, 40, 133-140.
25) Zhu H, Hua XX, Gong T, Pang J, Hou Q, and Zhu P*. Hypocreaterpenes A and B, cadinane-type sesquiterpenes from a marine-derived fungus, Hypocreales sp. Phytochem Lett. 2013, 6, 392-396.
26) Li CQ, Liu WC, and Zhu P*, Yang JL, and Cheng KD. Phylogenetic diversity of bacteria associated with the marine sponge Gelliodes carnosa collected from the Hainan island coastal waters of the South China Sea. Microb. Ecol. 2011,62, 800-812.
27) Liu WC, Li, CQ, Zhu P*. Yang JL, and Cheng KD. Phylogenetic diversity of culturable fungi associated with two marine sponges: Haliclona simulans and Gelliodes carnosa, collected from the Hainan Island coastal waters of the South China Sea. Fungal Divers. 2010, 42, 1-15.

1. Liu WC, Li BJ, Gong T, and Zhu P (2020). Exploring alternative Taxol sources: Biocatalysis of 7-β-xylosyl-10-deacetyltaxol and application for Taxol production. In: Pharmaceutical Biocatalysis. Peter Grunwald eds. Jenny Stanford Publishing.
2. Liu WC and Zhu P (2018). Demonstration-scale high-cell-density fermentation of Pichia pastoris. In: Recombinant Glycoprotein Production: Methods and Protocols. Methods in Molecular Biology, Vol 1674, Picanço-Castro V and Swiech K eds. Humana Press, New York, NY.
3. Zhu P and Wn H (2011). Medicinal fungal research in China. In: McGraw-Hill Year Book of Science & Technology 2011. Blumel D et al. eds. The McGraw-Hill Companies, Inc.
4. Cheng K, Liu T, Meng C, and Zhu P (2007). Biotechnological studies on Anisodus tanguticus. In: Recent Progress in Medicinal Plants. Volume 16, Book chapter: Phytomedicines. Govil JN et al. eds. Studium Press LLC, U.S.A.
5. 《中国食用药用菌化学》 陈若芸 主编. 第五章 蕈菌毒素(巩婷, 朱平), 第十六章 麦角菌(陈晶晶,王维波,巩婷, 朱平). 上海科学技术文献出版社, 2016.
6. 《天然药物化学研究》方起程 主编. 第七章 第三节 麦角生物碱生物合成的研究(朱平,胡晨曦), 第四节 后基因组时代与天然药物化学——紫杉烷类化合物生物合成(程克棣, 王伟, 朱平 ).中国协和医科大学出版社, 2006.

1. 朱平，朱海波，朱慧新，张岭，何惠霞，王全，程克棣，石建功，杨永春. 3ʹ-脱氧腺苷在制备降血脂药物中的应用. ZL 200310101650.7.
2. 朱海波，吴松，郝玲花，渠凯，朱平，王星，李薇. 三乙酰基-3-羟基苯基腺苷及其调血脂的用途. PCT/CN2009/070725, ZL 200980101131.6, US 8,435,962, EU 2407474, JP 5698682, KR10-1380140, IL 215080.
3. 朱平，程海立，赵瑞玉，程克棣，何惠霞，孟超，朱慧新. 一种7-木糖紫杉烷糖基水解酶、其基因的核苷酸序列及其应用. ZL 201010209089.4
4. 朱平，程海立，赵瑞玉，程克棣，何惠霞，孟超，朱慧新. 具有-木糖苷酶和-葡萄糖苷酶活性的糖基水解酶及其应用. PCT/WO2011/160484A1, ZL 201180031238.5, US 9,206,405 B2, EP2586860B1, CA2804879, JP 5868395 B2, KR10-1830131.
5. 朱平，梁潇，王芬，李慧仙，陈天娇. 具有β-木糖苷酶和β-葡萄糖苷酶双重活性的糖基水解酶突变体及其应用. ZL 2016 1 0141218.8.
6. 朱平，李炳娟，王豪，陈天娇，陈晶晶，巩婷，杨金玲.10-去乙酰巴卡亭III 10β-O-乙酰转移酶突变体及其在催化合成紫杉醇及其类似物中的应用. ZL 201610346558.4.
7. 朱平，李炳娟，王豪，陈天娇，陈晶晶，巩婷，杨金玲. 利用10-去乙酰巴卡亭III 10β-O-乙酰转移酶突变体催化合成紫杉醇及其类似物. ZL 202110477408.8.
8. 杨金玲，朱平，李燕，陈天娇，顾安頔，杜倩倩. 3β-O-Glc-DM和20S-O-Glc-DM治疗肺癌或结直肠癌的用途. ZL 201980075637.8
9. 杨金玲，朱平，李燕，姜逢霖，杜倩倩，唐梅. 非天然人参皂苷 3β-O-Glc-DM 在制备预防或治疗胶质母细胞瘤药物中的应用. ZL 201910403991.0.
10. 李燕，杨金玲，朱平，唐梅，顾安頔. 稀有人参皂苷在治疗肾癌中的用途. ZL 202011129395.7.

1. 程克棣，朱平，孔建强，王伟，涂珺，刘涛，袁玮，刘颖，张利平. 稀有天然药物生物合成与合成生物学研究.中国药学会科学技术奖 三等奖（2011）。
2. 朱海波，吴松，朱平，渠凯，张成城，朱海亮. 基于虫草素结构优化的新型运动模拟候选药物研发关键技术及其应用. 中国发明协会发明创业奖 一等奖 (2022)。
3. 朱平. 北京协和医学院优秀教师 (2020)。