1. 抗缺血性脑卒中相关药物靶点确证、筛选模型建立及药物筛选、新药评价及机制研究。药物作用机制涉及神经炎症、神经新生、脑线粒体功能改善、血脑屏障保护、抗氧化应激、蛋白质非酶糖基化修饰等方面。
2. 将网络药理学分析、现代中药提取分离技术、高通量筛选技术及现代药理学活性评价技术相结合，对中药复方物质基础、药理活性进行系统研究，诠释中药复方的科学内涵，进行中药复方的二次开发。
3. 海洋来源药物候选物成药性评价。
职 称：研究员
所属科室：国家药物筛选中心
导师类别：博士生导师
联系方式：walling@imm.ac.cn
所属重点实验室：脑血管病新药发现及晶型研究北京市重点实验室
1. 抗缺血性脑卒中相关药物靶点确证、筛选模型建立及药物筛选、新药评价及机制研究。药物作用机制涉及神经炎症、神经新生、脑线粒体功能改善、血脑屏障保护、抗氧化应激、蛋白质非酶糖基化修饰等方面。
2. 将网络药理学分析、现代中药提取分离技术、高通量筛选技术及现代药理学活性评价技术相结合，对中药复方物质基础、药理活性进行系统研究，诠释中药复方的科学内涵，进行中药复方的二次开发。
3. 海洋来源药物候选物成药性评价。
1. Feng WD, Liu DN, Shang YF, Zhang WF, Xu S, Feng DH, Wang YH⁎. Neuroimmune modulators derived from natural products: Mechanisms and potential therapies. Pharmacology & Therapeutics, 2025, 269: 108830.
2. Liu DN, Zhang WF, Feng WD, Xu S, Feng DH, Song FH, Zhang HW, Fang LH, Du GH, Wang YH. Chrysomycin A Reshapes Metabolism and Increases Oxidative Stress to Hinder Glioblastoma Progression. Mar. Drugs 2024, 22, 391.
3. Liu DN, Liu M, Zhang SS, Shang YF, Zhang WF, Song FH, Zhang HW, Du GH*, Wang YH*. Chrysomycin A regulates proliferation and apoptosis of neuroglioma cells via the Akt/GSK-3β signaling pathway in vivo and in vitro. Mar Drugs 2023, 21, 329.
4. Cheng X, Yang YL, Li WH, Liu M, Zhang SS, Liu DN, Du LD, Wang YH*, Du GH*. Xiao-Xu-Ming decoction extracts promotes mitochondrial biogenesis and improves neurobehavioral deficits in cerebral ischemia/reperfusion rats. Pharmacol Res - MCM, 2022, 5, 100192 (1-9).
5. Zhang SS, Liu M, Liu DN, Shang YF, Du GH*, Wang YH*. Network pharmacology analysis and experimental validation of kaempferol in the treatment of ischemic stroke by inhibiting apoptosis and regulating neuroinflammation involving neutrophils. Int J Mol Sci, 2022, 23, 12694.
6. Liu DN, Liu M, Zhang SS, Shang YF, Song FH, Zhang HW, Du GH*, Wang YH*. Chrysomycin A inhibits the proliferation, migration and invasion of U251 and U87-MG glioblastoma cells to exert its anti-cancer effects. Molecules 2022, 27, 6148.
7. Zhang SS, Liu M, Liu DN, Shang YF, Wang YH*, Du GH*. ST2825, a small molecule inhibitor of MyD88, suppresses NF-κB activation and the ROS/NLRP3/cleaved caspase-1 signaling pathway to attenuate lipopolysaccharide-stimulated neuroinflammation. Molecules 2022, 27, 2990.
8. Zhang SS, Liu M, Liu DN, Yang YL, Du GH*, Wang YH*. TLR4 IN C34 inhibits lipopolysaccharide stimulated inflammatory responses via downregulating TLR4/ MyD88/NF κB/NLRP3 signaling pathway and reducing ROS generation in BV2 cells. Inflammation, 2022, 45(2): 838-850.
9. Liu M, Yang YL, Zhang SS, Liu DN, Fang LH*, Du GH, Wang YH*. RKC-B1 blocks activation of NF-κB and NLRP3 signaling pathways to suppress neuroinflammation in LPS-stimulated mice. Mar. Drugs 2021, 19, 429.
10. Liu M, Zhang SS, Liu DN, Yang YL, Wang YH*, Du GH*. Chrysomycin A attenuates neuroinflammation by down-regulating NLRP3/Cleaved caspase-1 signaling pathway in LPS-stimulated mice and BV2 cells. Int J Mol Sci, 2021, 22(13): 6799.
11. Li WH, Yang YL, Cheng X, Liu M, Zhang SS, Wang YH*, Du GH*. Baicalein attenuates caspase-independent cells death via inhibiting PARP-1 activation and AIF nuclear translocation in cerebral ischemia/ reperfusion rats. Apoptosis, 2020, 25: 354-369.
12. Cheng X, Yang YL, Li WH, Liu M, Zhang SS, Wang YH*, Du GH*. Dynamic alterations of brain Injury, functional recovery, and metabolites profile after cerebral ischemia/reperfusion in rats contributes to potential biomarkers. J Mol Neurosci, 2020, 70: 667-676.
13. Cheng X, Yang YL, Li WH, Liu M, Wang YH*, Du GH*. Cerebral ischemia-reperfusion aggravated cerebral infarction injury and possible differential genes identified by RNA-Seq in rats. Brain Res Bull, 2020, 156: 33-42.