2005年本科毕业于山东大学药学院。2008年硕士毕业于北京协和医学院药物研究所。2013年毕业于新加坡国立大学化学系药物化学专业，获得博士学位。同年获得中国优秀自费留学生奖学金。2017年入选国家级高层次人才项目。2017年4月作为中国医学科学院“高端人才引进计划”首位入选者，到北京协和医学院药物所工作，任课题组长。《药学学报》中英两刊青年编委。

化学生物学和创新药物发现。
（1）利用化学蛋白质组学技术，阐明活性分子的蛋白靶标和作用机制，开展机制指导的先导化合物发现。
（2）设计、合成小分子荧光探针，用于先导化合物的发现。

(1) Xu, M.; Ma, X.; Ye, Z.; Wang, F.; Xu, S.; Zhang, C.-J.* “Concentration-Dependent Enrichment Identifies Primary Protein Targets of Multitarget Bioactive Molecules”. J. Proteome Res. 2023, 22, 802−811.
(2) Wang, K.#; Chen, L.#; Dai, X.#; Ye, Z.; Zhou, C.; Zhang, C.-J.*; Feng, Z.* “Synthesis and structure-activity relationships of N - (3 - (1H-imidazol-2-yl)phenyl) - 3-phenylpropionamide derivatives as a novel class of covalent inhibitors of p97/VCP ATPase.” Eur. J. Med. Chem., 2023, 248, 115094.
(3) Chen, K.#; Wang, T.#; Li, Y.#; Wu, J.#; Zhao, C.-X.; Liu, S.; Sun, F.; Fang, Y.; Hu, J.; Hu, J.; Zhang, C.-J.*; Yu. H.*; Ma, C.*; Yu, S.-S.* “Rhodojaponin VI indirectly targets Cav2.2 channels via N-ethylmaleimide-sensitive fusion protein to alleviate neuropathic pain”. Acta Pharm. Sin. B. 2023,13, 1326-1336.
(4) Liu, S.#; Wei, C.#; Liu, T.#; Ma, S.-G.#; Chen, C.; Lin, H.; Zhang, L.; Wang, H.*; Zhang, C.-J.*; Yu, S.-S.* “A heme-activatable probe and its application in the high-throughput screening of Plasmodium falciparum ring-stage inhibitors”. Signal Transduct Target Ther, 2022, 7, 160.
(5) Ye, Z.#; Wang, K.#; Chen, L.; Jin, X.; Chen, H.; Tang, G.; Yao, S.Q.; Feng, Z.*; Zhang, C.-J.* “A targeted covalent inhibitor of p97 with proteome-wide selectivity”. Acta Pharm. Sin. B. 2022,12, 982-989.
(6) Chen, L.; Wang, H.; Ji, T.-F.*; Zhang, C.-J.* “Chemoproteomics-based target profiling of sinomenine reveals multiple protein regulators of inflammation”. Chem. Commun., 2021, 57, 5981-5984.
(7) Zhao, C.; Liu, T.; Xu, M.; Lin, H.; Zhang, C.-J.* “A fundamental study on the fluorescence-quenching effect of nitro groups in tetraphenylethene AIE dyes with electron-withdrawing groups”. Chin. Chem. Lett. 2021, 32, 1925-1928.
(8) Wei, C.; Zhao, C.; Liu, S.; Zhao, J.; Ye, Z; Wang, H.*; Yu, S.*; Zhang, C.-J.* “Activity-based protein profiling reveals thatsecondary-carbon-centered radicals of synthetic 1,2,4-trioxolanes are predominately responsible for modification of protein targets in malaria parasites”. Chem. Commun., 2019, 55, 9535.
(9) Lin, H.; Yang, W.-Q; Ye, Z; Zhang, C.-J*. “Identification of Potent Caspase-8 Inhibitors from a Library of Fluorescent Natural Products Screened by an AIEgen-based Light-up Probe.” ChemBioChem, 2019, 20, 1292 – 1296. (Invited paper in the special issue of young ChemBio Talent).
(10) Lin, H.; Yang, H.; Huang, S.; Wang, F.; Wang, D.-M.; Liu, B*.; Tang, Y.-D*.; Zhang, C.-J*., Caspase‑1 Specific Light-Up Probe with Aggregation-Induced Emission Characteristics for Inhibitor Screening of Coumarin-Originated Natural Products. ACS Appl. Mater. Interfaces. 2018, 10, 12173−12180.
(11) Feng, G.; Liu, J.; Zhang, C.-J*.; Liu, B*. Artemisinin and AIEgen Conjugate for Mitochondria-Targeted and Image-Guided Chemo- and Photodynamic Cancer Cell Ablation. ACS Appl. Mater. Interfaces. 2018, 10, 11546−11553.
(12) Yang, H.#; Wang, F.#; Zheng, J.; Lin, H.; Liu, B*.; Tang, Y.-D*.; Zhang, C.-J*. Super-quenched Molecular Probe Based on Aggregation-Induced Emission and Photoinduced Electron Transfer Mechanisms for Formaldehyde Detection in Human Serum. Chem Asian J. 2018, 13, 1432-1437.
(13) Zhang, C.-J.#; Wang, J.#*; Zhang, J.; Lee, Y. M.; Feng, G.; Lim, T. K.; Shen, H.; Lin, Q.; Liu, B*. Mechanism-Guided Design and Synthesis of Mitochondria-targeting Artemisinin Analogue with Enhanced Anticancer Activity. Angew. Chem. Int. Ed., 2016, 55, 13770-13774.
(14) Zhang, C.-J.; Feng, G.; Xu. S.; Zhu, Z.; Lu. X.; Wu. J.; Liu, B*. Structure-dependent cis/trans Isomerization for TetraphenyletheneDerivatives: Consequences for Aggregation-Induced Emission. Angew. Chem. Int. Ed., 2016, 55, 6192-6196. (Selected as Very Important Paper).
(15) Zhang, C.-J.#; Hu, Q.#; Feng, G.; Zhang, R.; Yuan, Y.; Liu, B*. Image-Guided Combination Chemotherapy and Photodynamic Therapy Using a Mitochondria-Targeted Molecular Probe with Aggregation-Induced Emission Characteristics. Chem. Sci., 2015, 6, 4580-4586.
(16) Wang, J. *#; Zhang, C.-J.#; Chia, W. N.; Loh, C. C. Y.; Li, Z.; Lee, Y. Q.; Lee, Y. M.; He, Y.; Yuan, L.; Liu, M.; Liew, C. X.; Zhang, J.; Lim, T. K.; Lim, C. K.; Shen, H. M.; Tan, K. S. W. *; Lin, Q. S*. Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat. Commun, 2015, 6, 10111.
(17) Zhang, C.-J.; Tan, C. Y. J.; Ge, J.; Na, Z.; Chen, G. Y. J.; Uttamchandani, M.; Sun, H.; Yao, S. Q*. Preparation of Small-Molecule Microarrays by trans-Cyclooctene Tetrazine Ligation and Their Application in the High-Throughput Screening of Protein–Protein Interaction Inhibitors of Bromodomains. Angew. Chem. Int. Ed., 2013, 52, 14060-14064. (Selected as Hot Paper).
(18) Yuan, Y.#; Zhang, C.-J.#; Kwok, R. T. K.; Xu, S.; Zhang, R.; Wu, J.; Tang, B. Z.; Liu, B*. Light-up Probe for Targeted and Activatable Photodynamic Therapy with Real-time In-situ Reporting of Sensitizer Activation and Therapeutic Responses. Adv. Funct. Mater, 2015, 25, 6586-6595.
(19) Yuan, Y.#; Zhang, C.-J.#; Liu, B*. A Photoactivatable AIE Polymer for Light-Controlled Gene Delivery: Concurrent Endo/Lysosomal Escape and DNA Unpacking. Angew. Chem. Int. Ed., 2015, 54, 11419-11423.
(20) Yuan, Y.#; Zhang, C.-J.#; Gao, M.; Zhang, R.; Tang, B. Z.; Liu, B*. Specific Light-Up Bioprobe with Aggregation-Induced Emission and Activatable Photoactivity for the Targeted and Image-Guided Photodynamic Ablation of Cancer Cells. Angew. Chem. Int. Ed., 2015, 54, 1780-1786.
*corresponding author； # equal contribution