肿瘤预后及免疫治疗新靶标；
基于人工智能与生物信息学的疾病新靶点发现及药物筛选；
心血管疾病的分子靶点及新药研究；
环境毒物诱导疾病的网络毒理机制及关键靶点研究；
天然产物药效与药理机制研究。

1. Silin Lv, Mingxuan Zhou, Tiegang Li, Zifan Zeng, Zheng Yan, Yufang Hou, Liu Yang, Fang Zhang, Wenyi Zhao, Yixin Zhou, Min Yang*. CCL5 promotes angiogenesis II-induced cardiac remodeling through regulation of platelet-driven M2 macrophage polarization. Theranostics. 2026 Jan 1;16(2):689-711. (IF:13.3)
2. Wenyi Zhao, Tiegang Li, Jinbao Zong, Fang Zhang, Mingxuan Zhou, Yufang Hou, Zheng Yan, Silin Lv, Zifan Zeng, Liu Yang, Yuexia Che, Xinyi Ren, Yixin Zhou, Zengni Zhu, Min Yang*. Crosstalk between the Wnt signaling pathway and axon guidance molecules reveals a novel signature for accurately predicting diagnosis, prognosis, and immune landscape in colorectal cancer. International Journal of Surgery. 2026 Feb 1;112(2):3055-3070. (IF:10.3)
3. Tiegang Li, Zheng Yan, Wenyi Zhao, Yufang Hou, Silin Lv, Zifan Zeng, Liu Yang, Mingxuan Zhou, Fang Zhang, Xinyi Ren, Yixin Zhou, Zengni Zhu, Siying Huang, Min Yang*. Unraveling the potential carcinogenic risk of bisphenols: a comprehensive network analysis and computational toxicology insights Human Genomics. 2026 Mar 14;20(1):75. doi: 10.1186/s40246-026-00948-5. (IF:4.3)
4. Weiqi Wang#, Mingxuan Zhou#, Tiegang Li, Wenqiang Gan, Silin Lv, Zheng Yan, Yufang Hou, Zifan Zeng, Liu Yang, Fang Zhang, Wenyi Zhao, Min Yang*. Identification of PLXNC1 as a novel biomarker for consensus molecular subtype 4 in colorectal cancer. Genes & Diseases. 2025 Dec 11. doi:10.1016/j.gendis.2025.101974 (IF:9.4)
5. Yufang Hou, Yuexia Che, Tiegang Li, Zheng Yan, Wenyi Zhao, Silin Lv, Fang Zhang, Mingxuan Zhou, Yixun Zhou, Zengni Zhu, Xinyi Ren, Siying Huang, Min Yang*. Exploring the mechanisms underlying effects of oxygenated polycyclic aromatic hydrocarbons exposure on inflammatory bowel disease. Ecotoxicology and Environmental Safety. 2025 Oct 1:304:119153. doi: 10.1016/j.ecoevo.2025.119153. (IF:6.1)
6. Tiegang Li, Zheng Yan, Mingxuan Zhou, Wenyi Zhao, Fang Zhang, Silin Lv, Yufang Hou, Zifan Zeng, Liu Yang, Yixin Zhou, Zengni Zhu, Xinyi Ren, Min Yang*. Integration of Untargeted Metabolomics, Network Pharmacology, Single-Cell RNA Sequencing, and Molecular Dynamics Simulation Reveals GOT1, CYP1A2, and CA2 as Potential Targets of Huang Qin Decoction Preventing Colorectal Cancer Liver Metastasis. Pharmaceuticals (Basel). 2025 Jul 17;18(7):1052. doi: 10.3390/ph18071052. (IF:4.8)
7. Yufang Hou#, Fang Zhang#, Jinbao Zong, Tiegang Li, Wenqiang Gan, Silin Lv, Zheng Yan, Zifan Zeng, Liu Yang, Mingxuan Zhou, Wenyi Zhao, Min Yang*. Integrated analysis reveals a novel 5-fluorouracil resistance-based prognostic signature with promising implications for predicting the efficacy of chemotherapy and immunotherapy in patients with colorectal cancer. Apoptosis. 2024 Aug;29(7-8):1126-1144. (IF:8.1)
8. Mingxuan Zhou, Tiegang Li, Silin Lv, Wenqiang Gan, Fang Zhang, Yuexia Che, Liu Yang, Yufang Hou, Zheng Yan, Zifan Zeng, Wenyi Zhao, Min Yang*. Identification of immune-related genes and small-molecule drugs in hypertension-induced left ventricular hypertrophy based on machine learning algorithms and molecular docking. Frontiers in Immunology. 2024. doi: 10.3389/fimmu.2024.1351945 (IF:5.9)
9. Fang Zhang, Rixin Zhang, Jinbao Zong, Yufang Hou, Mingxuan Zhou, Zheng Yan, Tiegang Li, Wenqiang Gan, Silin Lv, Liu Yang, Zifan Zeng, Wenyi Zhao, Min Yang*. Computational identification and clinical validation of a novel risk signature based on coagulation-related lncRNAs for predicting prognosis, immunotherapy response, and chemosensitivity in colorectal cancer patients. Frontiers in Immunology. 2023. doi: 10.3389/fimmu.2023.1279789 (IF:5.7)
10. Rixin Zhang, Wenqiang Gan, Jinbao Zong, Yufang Hou, Mingxuan Zhou, Zheng Yan, Tiegang Li, Silin Lv, Zifan Zeng, Weiqi Wang, Fang Zhang, Min Yang*. Developing an mSC regulator-mediated RNA methylation modification signature to predict prognosis and immunotherapy efficacy in rectal cancer. Frontiers in Immunology. 2023. doi: 10.3389/fimmu.2023.1054700 (IF:5.7)
11. Mingxuan Zhou, Silin Lv, Yufang Hou, Rixin Zhang, Weiqi Wang, Zheng Yan, Tiegang Li, Wenqiang Gan, Zifan Zeng, Fang Zhang, Min Yang*. Characterization of sialylation-related long noncoding RNAs to develop a novel signature for predicting prognosis, immune landscape, and chemotherapy response in colorectal cancer. Frontiers in Immunology. 2022. doi: 10.3389/fimmu.2022.994874 (IF:7.3)
12. Yufang Hou, Rixin Zhang, Jinbao Zong, Weiqi Wang, Mingxuan Zhou, Zheng Yan, Tiegang Li, Wenqiang Gan, Silin Lv, Zifan Zeng, Min Yang*. Comprehensive analysis of a cancer-immunity cycle-based signature for predicting prognosis and immunotherapy responses in patients with colorectal cancer. Frontiers in Immunology. 2022. doi: 10.3389/fimmu.2022.892512 (IF:7.3)
13. Tiegang Li, Weiqi Wang, Wenqiang Gan, Silin Lv, Zifan Zeng, Yufang Hou, Zheng Yan, Rixin Zhang, Min Yang*. Comprehensive bioinformatics analysis identifies LAPTM5 as a potential blood biomarker for hypertensive patients with left ventricular hypertrophy. Aging-US; 2022. 14(3): 1508-1528. (IF: 5.2)
14. Wenqiang Gan, Weiqi Wang, Tiegang Li, Rixin Zhang, Yufang Hou, Silin Lv, Zifan Zeng, Zheng Yan, Min Yang*. Prognostic values and underlying regulatory network of Cohesin subunits in esophageal carcinoma. Journal of Cancer; 2022. 13(5): 1588-1602. (IF: 3.9)
15. Silin Lv, Zifan Zeng, Wenqiang Gan, Weiqi Wang, Tiegang Li, Yufang Hou, Zheng Yan, Rixin Zhang, Min Yang*. Lp-PLA2 inhibition prevents Ang II-induced cardiac inflammation and fibrosis by blocking macrophage NLRP3 inflammasome activation. Acta Pharmacologica Sinica; 2021.42(12): 2016-2032. (IF:7.165)
16. Tiegang Li#, Zheng Yan#, Weiqi Wang, Rixin Zhang, Wenqiang Gan, Silin Lv, Zifan Zeng, Yufang Hou, Min Yang*. SEMA6B overexpression predicts poor prognosis and correlates with the tumor immunosuppressive microenvironment in colorectal cancer. Frontiers in Molecular Biosciences. 2021. doi: 10.3389/fmolb.2021.687319 (IF: 6.113)