刘陆平课题组关注新型化学生物学技术在新药创制中应用,致力于药物化学生物学前沿研究：
1. 生物药物和共价小分子药物的研发；
2. 智能生物正交化学的开发及其药学应用；
3. 生物相容性化学反应及其药学应用探索。

1. Dongqing Ming; Jiaxue Zhang; Binsong Mu; Dongxue Peng; Yanjun Wang; Yangyang Kong; Wenjing Wang; Ling Chu; Rui Wang*; Luping Liu*. Reactive Oxygen Species-Activated Bioorthogonal Chemistry in Living Systems Enabled by Boronate-Caged Dihydrotetrazines, Nature Communications, 2026, 17(1): 2568.
2. Hao Liu; Hui Xu; Lei Yang; Dan Zhang; Yanjun Wang; Jieting Shen; Xinyun Ma; Jiaxiang Wang; Yangyang Kong; Xian Jia; Kuan Hu; Rui Wang*; Luping Liu*. Tetrazine-Enabled Peptide Macrocyclization and Bioorthogonal Cell Penetration Profiling, Journal of the American Chemical Society Au, 2026.
3. Pengxin Wang; Jinyuan Gong; Yuntao Shi; Luping Liu*; Rui Wang*. Construction-modification method of β-sheet peptides guided by dehydroalanine properties, Chinese Chemical Letters, 2026, 112431.
4. Luping Liu; Dongyang Zhang; Mai Johnson; Neal K. Devaraj*. Light-activated tetrazines enable precision live-cell bioorthogonal chemistry, Nature Chemistry, 2022, 14: 1078–1085.
5. Dongyang Zhang; Luping Liu; Shuaijiang Jin; Ember Tota; Zijie Li; Xijun Piao; Xuan Zhang; Xiang-Dong Fu; Neal K. Devaraj*. Site-Specific and Enzymatic Cross-Linking of sgRNA Enables Wavelength-Selectable Photoactivated Control of CRISPR Gene Editing, Journal of the American Chemical Society, 2022, 144(10): 4487–4495.
6. Dongyang Zhang; Susan Q. Lang; K. N. Houk; Neal K. Devaraj*. Enzyme-free synthesis of natural phospholipids in water, Luping Liu; Yike Zou; Ahanjit Bhattacharya, Nature Chemistry, 2020, 12: 1029–1034.
7. Luping Liu; Hyejin Kim; Youwei Xie; Christophe Farés; Philip S. J. Kaib; Richard Goddard; Benjamin List*. Catalytic Asymmetric [4+2] Cycloaddition of Dienes with Aldehydes, Journal of the American Chemical Society, 2017, 139(39): 13656–13659.
8. Luping Liu; Philip S. J. Kaib; AurélienTap; Benjamin List*. A General Catalytic Asymmetric Prins Cyclization, Journal of the American Chemical Society, 2016, 138(34): 10822–10825.
9. Sayantani Das; Luping Liu; Yiying Zheng; M. Wasim Alachraf; Walter Thiel*; Chandra Kanta De*; Benjamin List*. Nitrated Confined Imidodiphosphates Enable a Catalytic Asymmetric Oxa-Pictet-Spengler Reaction, Journal of the American Chemical Society, 2016, 138(30): 9429–9432
10. Luping Liu; Markus Leutzsch; Yiying Zheng; M. Wasim Alachraf; Walter Thiel; Benjamin List*. Confined Acid-Catalyzed Asymmetric Carbonyl-Ene Cyclization, Journal of the American Chemical Society, 2015, 137(41): 13268–13271.
11. Gavin Chit Tsui; Luping Liu; Benjamin List*. The Organocatalytic Asymmetric Prins Cyclization, Angewandte Chemie International Edition, 2015, 54(26): 7703–7706.
12. Xianxing Jiang*; Luping Liu; Panpan Zhang; Yuan Zhong; Rui Wang*. Catalytic Asymmetric β,γ Activation of α,β-Unsaturated γ-Butyrolactams: Direct Approach to β,γ-Functionalized Dihydropyranopyrrolidin-2-ones, Angewandte Chemie International Edition, 2013, 52(43): 11329–11333.