范武发，助理教授，博士生导师。2019年毕业于复旦大学药学院，获药剂学博士学位。2019.07-2022.06于北京大学化学与分子工程学院和浙江大学化学工程与生物工程学院从事博士后研究。2022年11月作为“高层次引进人才”入职中国医学科学院&北京协和医学院药物研究所，获聘北京协和医学院助理教授，课题组长。目前，在Nature Biomedical Engineering、Advanced Materials、Nano Today、Nano Letters、Acta Pharmaceutica Sinica B等国际著名期刊上发表SCI论文十余篇。

课题组致力于药物递送研究，通过合成高分子、脂质材料，构建智能纳米药物，实现肿瘤、中枢系统疾病的高效治疗，具体研究方向包括：1. 生物医用高分子、脂质材料的合成与应用；2. 纳米药物跨生理/病理屏障递送及机制；3. 纳米药物肿瘤免疫治疗；4. 多肽、蛋白、核酸等大分子药物递送；5. 纳米药物生物学效应。

1. Wufa Fan#, Jiajia Xiang#, Qiuyu Wei#, Yisi Tang#, Ying Piao, Shiqun Shao, Zhuxian Zhou*, Jianbin Tang, Zi-Chen Li*, Youqing Shen*. Role of micelle size in cell transcytosis-based tumor extravasation, infiltration, and treatment efficacy. Nano Letters, 2023, 23, 3904-3912.
2. Wufa Fan, Qiuyu Wei, Jiajia Xiang, Yisi Tang, Quan Zhou, Yu Geng, Yanpeng Liu, Rui Sun, Lei Xu, Guowei Wang, Ying Piao, Shiqun Shao*, Zhuxian Zhou, Jianbin Tang, Tao Xie, Zichen Li*, Youqing Shen*. Mucus penetrating and cell-binding polyzwitterionic micelles as potent oral nanomedicine for cancer drug delivery. Advanced Materials, 2022, 34, 2109189.
3. Siqin Chen#, Yin Zhong#, Wufa Fan#, Jiajia Xiang#, Guowei Wang, Quan Zhou, Jinqiang Wang, Yu Geng, Rui Sun, Zhen Zhang, Ying Piao, Jianguo Wang, Jianyong Zhuo, Hailin Cong, Haiping Jiang, Jun Ling, Zichen Li, Dingding Yang, Xin Yao, Xiao Xu, Zhuxian Zhou, Jianbin Tang, Youqing Shen*. Enhanced tumour penetration and prolonged circulation in blood of polyzwitterion-drug conjugates with cell-membrane affinity. Nature Biomedical Engineering, 2021, 5, 1019-1037.
4. Yisi Tang#, Wufa Fan#, Guihua Chen, Meng Zhang, Xueping Tang, Hairui Wang, Pengfei Zhao, Qin Xu, Zhibing Wu*, Xiaoxi Ling, Yongzhuo Huang*. Recombinant cancer nanovaccine for targeting tumor-associated macrophage and remodeling tumor microenvironment. Nano Today, 2021, 40, 101244.
5. Wufa Fan, Haixia Peng, Zhou Yu, Luting Wang, Haisheng He, Yuhua Ma, Jianping Qi, Yi Lu, Wei Wu*. The long-circulating effect of pegylated nanoparticles revisited via simultaneous monitoring of both the drug payloads and nanocarriers. Acta Pharmaceutica Sinica B, 2022, 12, 2479-2493.
6. Wufa Fan#, Zhou Yu#, Haixia Peng, Haisheng He, Yi Lu, Jianping Qi, Xiaochun Dong, Weili Zhao, Wei Wu*. Effect of particle size on the pharmacokinetics and biodistribution of parenteral nanoemulsions. International Journal of Pharmaceutics, 2020, 586, 119551.
7. Zhou Yu#, Wufa Fan#, Luting Wang, Haisheng He, Yongjiu Lv, Jianping Qi, Yi Lu, Wei Wu*. Slowing down lipolysis significantly enhances the oral absorption of intact solid lipid nanoparticles. Biomaterials Science, 2019, 7, 4273-4282.