研究方向为药用天然产物的生物合成及合成生物学研究，主要致力于从中药植物、特殊生境微生物中发现、揭示复杂结构活性天然产物生物合成关键酶基因的功能及酶催化分子机制；设计、改造生物合成酶，开展天然产物的酶催化结构修饰、生物合成途径重构和合成生物学研究。通过工程酶/微生物/植物进行重要活性复杂结构天然产物的异源生产，高效、可设计性合成结构多样的创新药用活性分子。

1. Ridao Chen#, Bingquan Gao#, Xiao Liu#, Feiying Ruan, Yong Zhang, Jizhong Lou, Keping Feng, Carsten Wunsch, Shu-Ming Li, Jungui Dai*, Fei Sun*. Molecular insights into the enzyme promiscuity of an aromatic prenyltransferase. Nature Chemical Biology, 2017, 13, 226–234. (IF: 13.843)
2. Yu-Hsuan Lee#, Xueli Hou#, Ridao Chen#, Jianqiang Feng, Xiao Liu, Mark W Ruszczycky, Jin-Ming Gao*, Binju Wang*, Jiahai Zhou*, Hung-Wen Liu*. Radical S-adenosyl methionine enzyme BlsE catalyzes a radical-mediated 1,2-diol dehydration during the biosynthesis of blasticidin S. Journal of the American Chemical Society, 2022, 144, 4478–4486. (IF: 15.0)
3. Changkang Li#, Shuai Wang#,*, Xinxin Yin, Aobo Guo, Kebo Xie, Dawei Chen, Songyang Sui, Yaotian Han, Jimei Liu, Ridao Chen*, Jungui Dai*. Functional characterization and cyclization mechanism of a diterpene synthase catalyzing the skeleton formation of cephalotane-type diterpenoids. Angewandte Chemie International Edition, 2023, 62, e202306020. (IF: 16.6)
4. Yuyu Liu#, Xinnan Li#, Songyang Sui#, Jingshu Tang, Dawei Chen, Yuying Kang, Kebo Xie, Jimei Liu, Jiaqi Lan, Lei Wu, Ridao Chen*, Ying Peng*, Jungui Dai*. Structural diversification of bioactive bibenzyls through modular co-culture leading to the discovery of a novel neuroprotective agent. Acta Pharmaceutica Sinica B, 2022, 13, 1771–1785. (IF: 14.5)
5. Jiawei Sun, Jimei Liu, Ridao Chen*, JunguiDai*. Dengratiols E-G, three bioactive pairs of enantiomeric bibenzyl dimers from Dendrobium gratiosissimum. Fitoterapia, 2022, 162, 105295. (IF: 3.204)
6. Shuqin Liu, Beilei Yu, Jungui Dai, Ridao Chen*. Targeting the biological activity and biosynthesis of hyperforin: a mini-review. Chinese Journal of Natural Medicines, 2022, 20, 721–728. (IF: 3.887)
7. Cong Su#, Yangyang Duan#, Jinying Tian, Jimei Liu, Kebo Xie, Dawei Chen, Fei Ye, Ridao Chen*, Jungui Dai*. Morusalisins A-F, six new Diels-Alder type adducts, as potential PTP1B inhibitors from cell cultures of Morus alba. Fitoterapia, 2020, 146, 104682. (IF: 2.502)
8. Jianhua Li #, Ridao Chen #, Ruishan Wang, Xiao Liu, Kebo Xie, Dawei Chen, Jungui Dai *. Biocatalytic access to diverse prenylflavonoids by combining a regiospecific C-prenyltransferase and a stereospecific chalconeisomerase. Acta Pharmaceutica Sinica B, 2018, 8, 678–686. (IF: 6.014)
9. Ridao Chen, Zheng Yan, Jianhua Zou, Nan Wang, Jungui Dai*. Rubratoxin C, a new nonadride derivative from an endophytic fungus Penicillium sp. F-14. Chinese Chemical Letters, 2014, 25, 1308–1310. (IF: 1.587)
10. Ridao Chen, Xiao Liu, Jianhua Zou, Yunze Yin, Bin Ou, Jianhua Li, Ruishan Wang, Dan Xie, Peicheng Zhang, Jungui Dai *. Regio- and stereospecific prenylation of flavonoids by Sophora flavescens prenyltransferase. Advanced Synthesis & Catalysis, 2013, 355, 1817–1828. (IF: 5.542)