主要研究方向为肥胖、糖尿病等代谢相关疾病的病理机制阐释、潜在药物靶点发掘及原创新药创制研究:
1. 胰岛素抵抗相关新靶点发现及相关新药的创制研究；
2. 代谢功能障碍相关脂肪性肝病/肝炎（MASLD/MASH）新机制探索及新药创制研究；
3. 糖尿病肾病等糖尿病并发症的病理机制阐释和相关新药创制研究。

1. Liu Xingfeng*; Chen Jingwen*; Gu Shengying*; Chen Yibing; Zhang Ruiping; Zang Qingce; Li Ting; Li Hanwen; Lu Dejin; Hou Shaocong; Kong Lijuan; Jiang Qian; Xing Caiyi; Fan Wenjia; Wan Yanjun; Zhang Jiaqi; Zhu Linyuan; Ma Chunxiao; Zhao Qijin; Yan Hai; Abliz Zeper; Cui Bing#; Li Pingping#, Prolonged glucagon exposure rewires lipid oxidation and drives diabetic kidney disease progression, Nature Communications, 2025, 16(1): 8561.
2. Zhu Wenhui*; Wang Wenfan; Wang Yayun; Tong Xiaolin; Liu Xingfeng#; Zhang Lili#; Zhao Linhua#, Hepatocyte nuclear factor 1 in renal lipid metabolism: molecular mechanisms and therapeutic potentials, Cell Biology and Toxicology, 2025, 41(1): 157.
3. Liu Xingfeng*; Wang Kai*; Wang Luhai; Kong Lijuan; Hou Shaocong; Wan Yanjun; Ma Chunxiao; Chen Jingwen; Xing Xiaowei; Xing Caiyi; Jiang Qian; Zhao Qijin; Cui Bing; Huang Zhifeng#; Li Pingping#, Hepatocyte Ltb4r1 promotes NAFLD development in obesity. Hepatology, 2023, 78(2):562-577
4. Liu Xingfeng*; Wang Kai; Hou Shaocong; Jiang Qian; Ma Chunxiao; Zhao Qijin; Kong Lijuan; Chen Jingwen; Wang Zhenhe; Zhang Huabing; Yuan Tao; Li Yuxiu; Huan Yi; Shen Zhufang; Hu Zhuowei; Huang Zhifeng; Cui Bing; Li Pingping#, Insulin induces insulin receptor degradation in the liver through EphB4. Nature Metabolism, 2022, 4(9): 1202-1213.
5. Liu Xingfeng*; Xiong Cong*; Jia Shunji; Zhang Yu; Chen Ye-Guang; Wang Qiang; Meng Anming#, Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region, Nature Communications, 2013, 4(1): 1728.
6. Sun Qingrui*; Liu Xingfeng*; Gong Bo; Wu Di; Meng Anming; Jia Shunji#, Alkbh4 and Atrn Act Maternally to Regulate Zebrafish Epiboly., International Journal of Biological Sciences, 2017, 13(8): 1051-1066.
7. Chen Yibing*; Jiang Qian*; Xing Xiaowei; Xu Liu; Zhao Qijin; Zhang Qidong; Chen Jingwen; Ma Chunxiao; Liu Xingfeng; Lu Yinfei; Wan Yanjun; Kong Lijuan; Hou Shaocong; Lu Qian; Cui Bing; Guo Jiankan; Huang Hongdong#; Li Pingping#, Macrophage Derived Galectin-3 Promotes Renal Fibrosis and Diabetic Kidney Disease by Enhancing TGFβ1 Signaling, Advanced Science, 2025, 12(35): e04032.
8. Hou Shaocong*; Yu Hengcai*; Liu Caihong*; Johnson Andrew M. F.; Liu Xingfeng; Jiang Qian; Zhao Qijin; Kong Lijuan; Wan Yanjun; Xing Xiaowei; Chen Yibing; Chen Jingwen; Wu Qing; Zhang Peng; Jiang Changtao; Cui Bing; Li, Pingping#, Intestinal epithelial cell NCoR deficiency ameliorates obesity and metabolic syndrome, Acta Pharmaceutica Sinica B, 2024, 14(12): 5267-5285.
9. Jiang Qian; Zhao Qijin; Chen Yibing; Ma Chunxiao; Peng Xiaohong; Wu Xi; Liu Xingfeng; Wang Ruoran; Hou Shaocong; Kong Lijuan; Wan Yanjun; Wang Shusen; Meng Zhuo-Xian; Cui Bing; Chen Liangyi; Li Pingping, Galectin-3 impairs calcium transients and β-cell function, Nature Communications, 2024, 15(1): 3628.
10. Lijuan Kong*, Qijin Zhao*, Xiaojing Jiang*, Jinping Hu, Qian Jiang, Li Sheng, Xiaohong Peng, Shusen Wang, Yibing Chen, Yanjun Wan, Shaocong Hou, Xingfeng Liu, Chunxiao Ma, Yan Li, Li Quan, Liangyi Chen, Bing Cui, Pingping Li, Trimethylamine N-oxide impairs β-cell function and glucose tolerance, Nature Communications, 2024, 15(1): 2526.