主要从事神经药理学研究，特别是针对我国科学家自主发现的新型基因CKLF1为脑卒中治疗靶点的系统生物学与药理学研究，阐明了CKLF1在卒中后的病理学作用，解析了CKLF1的诱导表达机制，阐述了CKLF1作为脑卒中治疗靶点的可行性与优越性。在此基础上，构建了以CKLF1为靶点的抗脑卒中创新药物发现与评价体系，发现了一系列天然产物来源与人工合成的CKLF1抑制剂均具有良好的抗脑卒中药理学功效，为缺血性脑卒中的治疗提供了新的思路与理论基础。

1. Targeting and reprogramming microglial phagocytosis of neutrophils by ginsenoside Rg1 nanovesicles promotes stroke recovery. Kai-chao Hu, Jun-rui Ye, Ping-long Fan, Rui-fang Zheng, Sha-sha Wang, Ye Peng, Yuan Ruan, Xu Yan, Zhao Zhang*, Shi-feng Chu*, Nai-hong Chen*. Bioact Mater. 2025; 47:181-197.
2. CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction. Hong-yun Wang, Jun-rui Ye, Ye Peng, Wen-yu Ma, Hao-dong Chen, Hong-shuo Sun, Zhong-ping Feng, Wen-bin He, Gang Li, Shi-feng Chu*, Zhao Zhang*, Nai-hong Chen*. Autophagy. 2024;20(3):590-613.
3. CKLF1 disrupts microglial efferocytosis following acute ischemic stroke by binding to phosphatidylserine. Ping-long Fan, Hua-qing Lai, Hong-yun Wang, Kai-chao Hu, Yuan Ruan, Jun-rui Ye, Sha-sha Wang, Ye Peng, Wen-bin He, Gang Li, Xu Yan, Shi-feng Chu*, Zhao Zhang*, Nai-hong Chen*. Cell death and differentiation. 2025 Mar 8. doi: 10.1038/s41418-025-01475-x.
4. Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson's disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle. Sha-sha Wang, Ye Peng, Ping-long Fan, Jun-rui Ye, Wen-yu Ma, Qing-lin Wu, Hong-yun Wang, Ya-juan Tian, Wen-bin He, Xu Yan, Zhao Zhang*, Shi-feng Chu*, Nai-hong Chen*. Acta Pharmacol Sin. 2025; 46(2):308-325.
5. Esculetin facilitates post-stroke rehabilitation by inhibiting CKLF1-mediated neutrophil infiltration. Jia-qi He, Ruo-lan Yuan, Yu-tong Jiang, Ye Peng, Jun-rui Ye, Sha-sha Wang, Li-qing Li, Yuan Ruan, Pei-yi Li, Xu Yan, Wen-bin He, Gang Li, Shi-feng Chu*, Zhao Zhang*, Nai-hong Chen*. Acta Pharmacol Sin. 2025; 46(1):52-65.
6. A breakdown of metabolic reprogramming in microglia induced by CKLF1 exacerbates immune tolerance in ischemic stroke. Wen-Yu Ma, Qing-Lin Wu, Sha-Sha Wang, Hong-Yun Wang, Jun-Rui Ye, Hong-Shuo Sun, Zhong-Ping Feng, Wen-Bin He, Shi-Feng Chu*, Zhao Zhang*, Nai-Hong Chen* Journal of neuroinflammation. 2023;20(1):97.
7. A small molecular antagonist of CCR5 promoted neural repair post stroke. Qing-Lin Wu, Li-Yuan Cui, Wen-Yu Ma, Sha-Sha Wang, Zhao Zhang, Zhong-Ping Feng, Hong-Shuo Sun, Shi-Feng Chu*, Wen-Bin He*, Nai-Hong Chen*. Acta Pharmacol Sin. 2023. doi: 10.1038/s41401-023-01100-y
8. Ginsenoside Rg1 protects against ischemic/reperfusion-induced neuronal injury through miR-144/Nrf2/ARE pathway. Shi-Feng Chu, Zhao Zhang, Xin Zhou, Wen-Bin He, Chen Chen, Piao Luo, Dan-Dan Liu, Qi-di Ai, Hai-Fan Gong, Zhen-Zhen Wang, Hong-Shuo Sun, Zhong-Ping Feng, Nai-Hong Chen*. Acta pharmacol Sin. 2019;40(1):13-25.
9. Low corticosterone levels attenuate late life depression and enhance glutamatergic neurotransmission in female rats. Shi-Feng Chu, Zhao Zhang, Xin Zhou, Wen-Bin He, Bo Yang, Li-Yuan Cui, Hong-Yuan He, Zhen-Zhen Wang, Nai-Hong Chen*. Acta Pharmacol Sin. 2021;42(6):848-860.
10. Upregulating the Expression of Survivin-HBXIP Complex Contributes to the Protective Role of IMM-H004 in Transient Global Cerebral Ischemia/Reperfusion. Shi-Feng Chu, Zhao Zhang, Wei Zhang, Mei-Jin Zhang, Yan Gao, Ning Han, Wei Zuo, Hui-Yong Huang, Nai-Hong Chen*. Mol Neurobiol. 2017;54(1):524-540.
11. Combination of monoammonium glycyrrhizinate and cysteine hydrochloride ameliorated lipopolysaccharide/galactosamine-induced acute liver injury through Nrf2/ARE pathway. Shi-feng Chu, Zi-quan Niu, Qing-xin Guo, Hao-zhi Bi, Xin-yu Li, Fang-fang Li, Zhao Zhang, Wen-bin He, Peng Cao, Nai-hong Chen*, Xiao-yun Sun*. Eur J Pharmacol. 2020;882:173258.
12. Up-regulation of Nrf2/P62/Keap1 involves in the anti-fibrotic effect of combination of monoammonium glycyrrhizinate and cysteine hydrochloride induced by CCl4. Shi-feng Chu, Hao-zhi Bi, Xin-yu Li, Li-yuan Cui, Wen-bin He, Ya-juan Tian, Fei Liu, Ge Gao, Zheng-bin Wang, Nai-hong Chen*, Hong Wang*. Eur J Pharmacol. 2021;913:174628.
13. RTP801 is a critical factor in the neurodegeneration process of A53T α-synuclein in a mouse model of Parkinson's disease under chronic restraint stress. Zhao Zhang#, Shi-Feng Chu#, Sha-Sha Wang, Yi-Na Jiang, Yan Gao, Peng-Fei Yang, Qi-Di Ai, Nai-Hong Chen*. Br J Pharmacol. 2018;175(4):590-605.
14. A20 as a novel target for the anti-neuroinflammatory effect of chrysin via inhibition of NF-κB signaling pathway. Zhi-peng Li#, Shi-feng Chu#, Wen-bin He, Zhao Zhang, Jia-qi Liu, Li-yuan Cui, Xu Yan, De-fang Li, Nai-hong Chen*. Brain Behav Immun. 2019;79:228-235.
15. Neuronal chemokine-like-factor 1 (CKLF1) up-regulation promotes M1 polarization of microglia in rat brain after stroke. Xin Zhou, Ya-Ni Zhang, Fang-Fang Li, Zhao Zhang, Li-Yuan Cui, Hong-Yuan He, Xu Yan, Wen-Bin He, Hong-Shuo Sun, Zhong-Ping Feng, Shi-Feng Chu*, Nai-Hong Chen*. Acta Pharmacol Sin. 2022;43(5):1217-1230.
16. Regulatory T cells in ischemic stroke. Hong-Yun Wang, Jun-Rui Ye, Li-Yuan Cui, Shi-Feng Chu*, Nai-Hong Chen* Acta Pharmacol Sin. 2022;43(1):1-9.
17. The progress of chemokines and chemokine receptors in autism spectrum disorders. Jun-rui Ye, Hong-yun Wang, Li-yuan Cui, Shi-Feng Chu*, Nai-hong Chen*. Brain Res Bull. 2021;174:268-280.
18. Korean red ginseng alleviate depressive disorder by improving astrocyte gap junction function. Qing-Lian Zheng, Hao-Yu Zhu, Xin Xu, Shi-Feng Chu*, Li-Yuan Cui, Yi-Xiao Dong, Ying-Jiao Liu, Jia-Hong Zhan, Zhen-Zhen Wang, Nai-Hong Chen* J Ethnopharmacol. 2021;281:114466.
19. The versatile role of TREM2 in regulating of microglia fate in the ischemic stroke. Wen-Yu Ma, Sha-Sha Wang, Qing-Lin Wu, Xin Zhou, Shi-Feng Chu*, Nai-Hong Chen*. Int Immunopharmacol. 2022;109:108733.
20. CKLF1/CCR5 axis is involved in neutrophils migration of rats with transient cerebral ischemia. Chen Chen, Shi-Feng Chu*, Qi-di Ai, Zhao Zhang, Nai-Hong Chen*. Int Immunopharmacol. 2020;85:106577.