神经精神系统疾病发病机制
新靶点研究以及新药发现

1. Jingshu Tang, Yuying Kang, Yujun Zhou, Nianying Shang, Xinnan Li, Hongyue Wang, Jiaqi Lan, Shuai Wang, Lei Wu, Ying Peng. TIMP2 ameliorates blood-brain barrier disruption in traumatic brain injury by inhibiting Src-dependent VE-cadherin internalization. J Clin Invest. 2023 Nov 28;134(3):e164199. doi: 10.1172/JCI164199.
2. Jingshu Tang#, Yuying Kang#, Yujun Zhou, Qiuyu Chen, Jiaqi Lan, Xuebin Liu*, Ying Peng*; Umbilical cord mesenchymal stem cell-conditioned medium inhibits microglial activation to ameliorate neuroinflammation in amyotrophic lateral sclerosis mice and cell models. Brain Research Bulletin, 2023 Oct 1:202:110760.
3. Yong Zhang#, Jingshu Tang#, Yujun Zhou, Qiong Xiao, Qiuyu Chen, Hongyue Wang, Jiaqi Lan, Lei Wu, Ying Peng*; Short-term exposure to dimethyl fumarate (DMF) inhibits LPS-induced IκBζ expression in macrophages. Frontiers in Pharmacology, 2023, 14:1114897.
4. Jingshu Tang, Yuying Kang, Yujun Zhou, Xinnan Li, Jiaqi Lan, Lei Wu, Xinhong Feng*, Ying Peng*; ALS-causing SOD1 mutants regulate occludin phosphorylation/ubiquitination and endocytic trafficking via the ITCH/Eps15/Rab5 axis. Neurobiology of Disease, 2021, 153.
5. Jingshu Tang, Yuying Kang, Longjian Huang, Xinhong Feng, Lei Wu, Ying Peng*; Neuroprotective effects of Hemocoagulase Agkistrodon on experimental traumatic brain injury. Brain Research Bulletin, 2021, 170: 1-10.
6. Jingshu Tang, Yuying Kang, Longjian Huang, Lei Wu, Ying Peng*; TIMP1 preserves the blood–brain barrier through interacting with CD63/integrin β1 complex and regulating downstream FAK/Rho A signaling. Acta Pharmaceutica Sinica B, 2020, 10(6): 987-1003.
7. Jingshu Tang#, Jingxuan Zhang#, Yang Liu, Qinyuan Liao, Jing Huang, Zihan Geng, Weiyan Xu, Zhengzuo Sheng, Gregory Lee, Youhui Zhang, Jinfeng Chen, Liang Zhang*, Xiaoyan Qiu*; Lung squamous cell carcinoma cells express non-canonically glycosylated IgG that activates integrin-FAK signaling. 2018 Aug 28, 430:148-159.
8. Jingshu Tang, Bingxue Xie, Xiling Bian, Yu Xue, Ningning Wei, Jingheng Zhou, Yuchen Hao, Gang Li, Liangren Zhang*, Kewei Wang*; Identification and in vitro pharmacological characterization of a novel and selective α7 nicotinic acetylcholine receptor agonist, Br-IQ17B. Acta Pharmacol Sin, 2015 Jul, 36(7):800-12.