职 称：副研究员
所属科室：药物制剂研究室
导师类别：硕士生导师
联系方式：wanglulu@imm.ac.cn
所属重点实验室：药物传输技术及新型制剂北京市重点实验室
1992-1996 复旦大学上海医学院，理学士
2000-2003 北京协和医学院，理学硕士
2014-2017 北京协和医学院，医学博士
主持及参与了多项国家及省部级科研项目，其中国家级项目5项，省部级/院校级项目7项。主持国家科技重大专项-重大新药创制儿童用药品种及关键技术任务级课题一项、主持中国医学科学院医学与健康科技创新工程重大协同创新项目任务级课题一项。
负责及参加了多项药物研发工作。作为项目负责人，主持的药物开发项目三项，作为制剂工艺负责人，参加新药开发项目十余项，其中9项已经获得新药证书。
在国内外著名学术期刊上发表研究性论文四十余篇，其中SCI文章十余篇。多次应邀在国际会议上进行学术报告，如2nd World Congress on bilpolymers、9th Annual World Congress of Nano Science & Technology-2019、Scholar International Conference on Pharmaceutics and Drug Delivery Research等。
1. Functional Nano-vector Boost Anti-atherosclerosis Efficacy of Berberine in Apoe(-/-) mice. Xiaolei Ma(#), Tingting Zhang(#), Zhigang Luo, Xiaolin Li, Miao Lin, Rui Li, Peng Du, Xiaoyou Yu, Chen Ma, Pengju Yan, Jin Su, Lulu Wang,*, Yuhuan Li,*, Jiandong Jiang, Acta Pharm Sin B. 2020, 10(9):1769-1783.
2. Dual-Stimuli-Responsive Gut Microbiota-Targeting Berberine-CS/PT-NPs Improved Metabolic Status in Obese Hamsters, Hui-Hui Guo(#); Chen Ma(#); Wen-Sheng Zheng(#); Yang Luo(#); Cong Li; Xiao-Lin Li; Xiao-Lei Ma; Chen-Lin Feng; Ting-Ting Zhang; Yan-Xing Han; Zhi-Gang Luo; Yun Zhan; Rui Li; Lu-Lu Wang(*); Jian-Dong Jiang(*), Advanced Functional Materials, 2019, 29（14）：1808197
3. Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases. Hui-Hui Guo(#), Chen-Lin Feng(#), Wen-Xuan Zhang(#), Zhi-Gang Luo(#), Hong-Juan Zhang, Ting-Ting Zhang, Chen-Ma, Yun Zhan, Rui Li, Song Wu, Zeper Abliz, Cong Li, Xiao-Lin Li, Xiao-Lei Ma, Lu-Lu Wang(*), Wen-Sheng Zheng(*), Yan-Xing Han(*) & Jian-Dong Jiang(*) Nature Communications, 2019,10（1）：1981-1996.
4. Tumor-selective lipopolyplex encapsulated small active RNA hampers colorectal cancer growth in vitro and in orthotopic murine. Wang LL, Feng CL, Zheng WS, Huang S, Zhang WX, Wu HN, Zhan Y, Han YX(*), Wu S(*), Jiang JD(*) Biomaterials, 2017, 141: 13-28.
5. Chlorogenic acid effectively treats cancers through induction of cancer cell differentiation. Shuai Huang*, Lu-Lu Wang*, Ni-Na Xue, Cong Li, Hui-Hui Guo, Tian-Kun Ren, Yun Zhan, Wen-Bing Li, Jie Zhang, Xiao-Guang Chen, Yan-Xing Han(*), Jin-Lan Zhang(*), Jian-Dong Jiang(*).Theranostics, 2019; 9(23): 6745-6763.
6. Development of rectal delivered thermo-reversible gelling film encapsulating a 5-flfluorouracil hydroxypropyl--cyclodextrin complex. Lu-Lu Wang, Wen-Sheng Zheng, Shao-Hua Chen, Yan-Xing Han(*), Jian-Dong Jiang(*) Carbohydrate Polymers, 2016，137：9-18.
7. Self-assembling HA/PEI/dsRNA-p21 ternary complexes for CD44 mediated small active RNA delivery to colorectal cancer. Chen-Lin Feng, Yan-Xing Han, Hui-Hui Guo, Xiao-Lei Ma, Zhi-Qiang Wang, Lu-Lu Wang (*), Wen-Sheng Zheng (*) & Jian-Dong Jiang (*).Drug Delivery, 2017, 24 (1): 1537-1548.
8. Specific up-regulation of p21 by a small active RNA sequence suppresses human colorectal cancer growth. Lu-Lu Wang, Hui-Hui Guo, Yun Zhan, Chen-Lin Feng, Shuai Huang, Yan-Xing Han (*), Wen-Sheng Zheng (*), Jian-Dong Jiang*. Oncotarget, 2017, 8, (15): 25055-25065.
9. In situ delivery of thermos sensitive gel-mediated 5-fluorouracil microemulsion for the treatment of colorectal cancer. Lu-Lu Wang, Shuai Huang, Hui-Hui Guo, Yan-Xing Han (*), Wen-Sheng Zheng, Jian-Dong Jiang (*). Drug Design, Development and Therapy, 2016: 10 2855–2867.
10. Comprehensive evaluation of SCFA production in the intestinal bacteria regulated by berberine using gas-chromatography combined with polymerase chain reaction. Lu-Lu Wang (*), Hui-Hui Guo, Shuai Huang, Chen-Lin Feng, Yan-Xing Han (*), Jian-Dong Jiang (*). Journal of Chromatography B 1057 (2017) 70–80.
11. Development of in situ gelling and bio adhesive 5-Fluorouracil enema. Lu-Lu Wang, Wen-Sheng Zheng (*), Shao-Hua Chen, Xia-Qin Fang. Plos One. 2013, 8(8): e71037.
