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职 称:副研究员






2005/9 - 2010/7 北京协和医学院,药物化学,博士
2001/9 - 2005/7 河北医科大学,药学,学士
2014/5 - 至今 中国医学科学院,药物研究所,副研究员
2010/7 - 2014/5 中国医学科学院,医学实验动物研究所,助理研究员


1、 活性天然产物的合成与结构改造
2、 新药先导化合物的发现与优化


1. Pang S, Li SY, Cheng HZ, Luo ZH, Qi XL, Guan FF, Dong W, Gao S, Liu N, Gao X, Pan S, Zhang X, Zhang L, Yang YJ*, Zhang LF*. Discovery of an evodiamine derivative for PI3K/AKT/GSK3β pathway activation and AD pathology improvement in mouse models, Front Mol Neurosci, 2023, 15, 1025066.
2. Yang YJ, Yan DA, Cheng HZ, Nan GL, Hou XX, Ren L, Yang Y, Li XC, Tian JY, Ye F*, Xiao ZY*. Discovery of novel 1,2,4-triazole derivatives as xanthine oxidoreductase inhibitors with hypouricemic effects. Bioorg Chem, 2022, 129:106162.
3. Luo ZH, Wang YC, Pang S, Gao S, Liu N, Gao X, Zhang L, Qi XL, Yang YJ*, Zhang LF*. Synthesis and Bioactivity Evaluation of a Novel 1,2,4-Oxadiazole Derivative in vitro and in 3×Tg Mice. Drug Des Devel Ther, 2022, 16:3285-3296.
4. Yang YJ, Liu JN*, Pan XD*. Synthesis and antiviral activity of lycorine derivatives. J Asian Nat Prod Res, 2020, 22(12): 1188-1196.
5. Yang YJ, Wang K, Wu B, Yang Y, Lai FF, Chen XG, Xiao ZY*. Design, synthesis and biological evaluation of triaryl compounds as novel 20S proteasome inhibitors. Bioorg Med Chem Lett, 2020, 30(21):127508.
6. Pang S, Sun CX, Gao S, Yang YJ*, Pan XD*, Zhang LF*. Evodiamine derivatives improve cognitive abilities in APPswe/ PS1ΔE9 transgenic mouse models of Alzheimer's disease. Animal Models and Experimental Medicine, 2020, 3(3):193-199.
7. Yang YJ, Zhu CJ, Zhang M, Huang SJ, Lin JJ, Pan XD*, Su WP*. Condensation of anthranilic acids with pyridines to furnish pyridoquinazolones via pyridine dearomatization, Chem Comm, 2016, 52(87): 12869-12872.
8. Yang YJ, Guan FF, Bai L, Zhang L, Liu JN, Pan XD*, Zhang LF*. Quinolizidine alkaloids reduced mortality in EV71-infected mice by compensating for the levels of T cells, Bioorg Med Chem Lett, 2015, 35(17): 3526-3528.
9. Yang YJ, Ma J, Xiu JH, Bai L, Guan FF, Zhang L, Liu JN, Zhang LF*. Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice, Mar Drugs, 2014, 12:4086-4095.
10. Yang YJ, Xiu JH, Liu JN, Zhang L, Li XY, Xu YF, Qin C, Zhang LF*. Chebulagic acid, a hydrolyzable tannin, exhibited antiviral activity in vitro and in vivo against human enterovirus 71, International Journal of Molecular Science, 2013, 14(5):9618-9627.
11. Yang YJ, Xiu JH, Zhang LF, Qin C, Liu JN*. Antiviral activity of punicalagin toward human enterovirus 71 in vitro and in vivo, Phytomedicine, 2012, 20(1): 67-70.
12. Yang YJ, Zhang LF, Fan XX, Qin C, Liu JN*. Antiviral effect of geraniin on human enterovirus 71 in vitro and in vivo, Bioorg Med Chem Lett, 2012, 22(6):2209-2211.
13. Yang YJ, Yang YN, Jiang JS, Feng ZM, Liu HY, Pan XD, Zhang PC*. Synthesis and cytotoxic activity of heterocyclic ring-substituted phthalimide derivatives, Chin Chem Lett, 2010, 21(8): 902-904.