1. 活性天然产物的发现、结构优化与全合成
2. 抗肿瘤与神经退行性疾病药物的研究与开发
2015年加入药物所以来，作为项目负责人承担国家自然科学基金3项。研究主要围绕着活性天然产物开展相关工作，包括活性天然产物的发现、结构修饰及全合成等。累计发表学术论文50余篇，其中以第一或通讯作者（含共同）在Chemical Science、Journal of Medicinal Chemistry、Organic Letter、European Journal of Medicinal Chemistry等本领域主流期刊发表学术论文30余篇；申请中国发明专利15项，获得授权专利9项，申请PCT专利1项并分别获得美国和欧盟授权；作为主要完成人参与的1个抗肿瘤新药已成功实现转让。

1. Tao Xu, Fangfang Li, Zifan Feng, Chenyu Dang, Yang Yang, Jinrong Wang, Cai-Xia Zang, Xiu-Qi Bao, Shi-Shan Yu*, Dan Zhang*, Rubing Wang*, Eur. J. Med. Chem. 2025, 284, 117213.
2. Jiayang, Jianpei Zhang, Rongmei Gao,Wenrui Li, Jingyu Zhang, Qianru Wang, Mi Li, Haiqiang Wang, Guozhu Su, Li Li, Yuhuan Li, Rubing Wang*, Xiaojing Wang*, Shuanggang Ma*. J. Asian. Nat. Prod. Res. 2024, 26(2), 204-213.
3. Jinyao Yong#, Mi Li#, Wenrui Li#, Rongmei Gao, Guozhu Su, Haiqiang Wang, Jia Yang, Li Li, Yuhuan Li, Peter Scott, Rubing Wang*, Xiaojing Wang*, Shuanggang Ma*. seco- Sesquiterpenes and acorane-type sesquiterpenes with antiviral activity from the twigs and leaves of Illicium henryi Diels. Bioorg. Chem. 2023, 131: 106324.
4. Zifan Feng, Shanshan Zhu, Wenrui Li, Maojun Yao, Hualong Song*, Rubing Wang*. Current approaches and strategies to identify Hedgehog signaling pathway inhibitors for cancer therapy. Eur. J. Med. Chem. 2022, 244: 114867.
5. Rubing Wang#, Shuanggang Ma#*, Cooper S. Jamieson#, Rongmei Gao, Yunbao Liu, Yong Li, Xiaojing Wang, Yuhuan Li, Kendall N. Houk*, Jing Qu*, Shishan Yu*. Library construction of stereochemically diverse isomers of spirooliganin: their total synthesis and antiviral activity. Chem. Sci. 2021, 12: 7003-7011.
6. Jinyao Yong#, Wenrui Li#, Xiaojing Wang, Guozhu Su, Mi Li, Jianpei Zhang, Hongli Jia, Yuhuan Li, Rubing Wang*, Maoluo Gan*, Shuanggang Ma*. Illihenin A, an antiviral sesquiterpenoid with a cage-like tricyclo[6.2.2.01,5]dodecane skeleton from Illicium henryi. J. Org. Chem. 2021, 86: 2017-2022.
7. Qingyun Fang, Haishan Jin, Rubing Wang*, Liming Zhao*. A role for isatin azomethine imines as a dipolarophile in cycloaddition reactions. Org. Lett. 2020, 22: 7358-7362.
8. Rubing Wang#, Xiaodong Ren#, Jie He, Shanshan Zhu, Huiru Xie, Guozhu Su, Shuanggang Ma, Shishan Yu*. Burchellin and its stereoisomers: total synthesis, structural elucidation and antiviral activity. Org. Biomol. Chem. 2020, 18: 9081-9087.
9. Qingyun Fang, Haishan Jin, Rubing Wang*, Liming Zhao*. DABCO-mediated [3+3] cycloaddition of azomethine imines with in situ generated nitrile oxides from hydroximoyl chlorides. Chem. Comm. 2019, 55: 10587-10591.
10. Rubing Wang, Haining Lv, Shanshan Zhu, Xiaodong Ren, Song Xu, Shuanggang Ma, Yunbao Liu, Jing Qu*, Shishan Yu*. A novel and practical synthesis of CAT3: a phenanthroindolizidine alkaloid with potential in treating glioblastoma. RSC Adv. 2018, 8: 29301-29308.
11. Rubing Wang, Xiaojie Zhang, Chengsheng Chen, Guanglin Chen,Cristian Sarabia, Qiang Zhang, Shilong Zheng, Guangdi Wang, QiaoHong Chen*. Structure-activity relationship studies of 1,7-diheteroarylhepta-1,4,6-trien-3-ones with two different terminal rings in prostate epithelial cell models. Eur. J. Med. Chem. 2017, 133: 208.
12. Rubing Wang, Chengsheng Chen, Xiaojie Zhang, Guanglin Chen, Qiang Zhang, Shilong Zheng, Guangdi Wang, Qiaohong Chen*. Synthesis and evaluation of 1,7-diheteroarylhepta- 1,4,6-trien-2-ones as promising anticancer agents. Eur. J. Med. Chem. 2016, 110: 16.
13. Rubing Wang, Chengsheng Chen, Xiaojie Zhang, Changde Zhang, Guanglin Chen, Qiang Zhang, Shilong Zheng, Guangdi Wang, Qiaohong Chen*. Structure-activity relationship and pharmacokinetic studies of 1,5-diheteroarylpenta-1,4-dien-3-ones: A class of curcumin-based anticancer agents. J. Med. Chem. 2015, 58: 4713-4726.