一、 工作经历
2018.10-至 今 中国医学科学院药物研究所 副研究员
2015.09-2018.09 中国医学科学院药物研究所 助理研究员
2013.08-2015.07 美国加州州立大学 博士后研究员
二、教育背景
2009.09-2013.06 上海交通大学药学院 博士
2006.09-2009.06 中国药科大学药学院 硕士
2001.09-2005.06 海南师范大学化学系 本科
三、在研项目
靶向Hedgehog通路新型菲骈吲哚里西啶抗神经胶质瘤化合物的设计、合成及机制研究，国家自然科学基金面上项目，2021.1-2024.12，负责人

1. 活性天然产物的发现、结构优化与成药性研究
2. 多手性中心活性天然产物及其异构体的全合成
2006年至今一直从事药物化学领域研究工作，主要涉及活性天然产物的发现、结构修饰、全合成及新合成方法学研究。研究工作目前累计发表研究论文近50篇，包括以第一或通讯作者发表在本领域主流期刊Chemical Science、Journal of Medicinal Chemistry、Organic Letter、European Journal of Medicinal Chemistry等研究论文近30篇，申请中国发明专利12项，获得授权专利9项，申请PCT专利1项并分别获得美国和欧盟授权。

1. Jinyao Yong#, Mi Li#, Wenrui Li#, Rongmei Gao, Guozhu Su, Haiqiang Wang, Jia Yang, Li Li, Yuhuan Li, Peter Scott, Rubing Wang*, Xiaojing Wang*, Shuanggang Ma*. seco-Sesquiterpenes and acorane-type sesquiterpenes with antiviral activity from the twigs and leaves of Illicium henryi Diels. Bioorg. Chem. 2023, 131: 106324.
2. Zifan Feng, Shanshan Zhu, Wenrui Li, Maojun Yao, Hualong Song*, Rubing Wang*. Current approaches and strategies to identify Hedgehog signaling pathway inhibitors for cancer therapy. Eur. J. Med. Chem. 2022, 244: 114867.
3. Rubing Wang#, Shuanggang Ma#*, Cooper S. Jamieson#, Rongmei Gao, Yunbao Liu, Yong Li, Xiaojing Wang, Yuhuan Li, Kendall N. Houk*, Jing Qu*, Shishan Yu*. Library construction of stereochemically diverse isomers of spirooliganin: their total synthesis and antiviral activity. Chem. Sci. 2021, 12: 7003-7011.
4. Jinyao Yong#, Wenrui Li#, Xiaojing Wang, Guozhu Su, Mi Li, Jianpei Zhang, Hongli Jia, Yuhuan Li, Rubing Wang*, Maoluo Gan*, Shuanggang Ma*. Illihenin A, an antiviral sesquiterpenoid with a cage-like tricyclo[6.2.2.01,5]dodecane skeleton from Illicium henryi. J. Org. Chem. 2021, 86: 2017-2022.
5. Qingyun Fang, Haishan Jin, Rubing Wang*, Liming Zhao*. A role for isatin azomethine imines as a dipolarophile in cycloaddition reactions. Org. Lett. 2020, 22: 7358-7362.
6. Rubing Wang#, Xiaodong Ren#, Jie He, Shanshan Zhu, Huiru Xie, Guozhu Su, Shuanggang Ma, Shishan Yu*. Burchellin and its stereoisomers: total synthesis, structural elucidation and antiviral activity. Org. Biomol. Chem. 2020, 18: 9081-9087.
7. Qingyun Fang, Haishan Jin, Rubing Wang*, Liming Zhao*. DABCO-mediated [3+3] cycloaddition of azomethine imines with in situ generated nitrile oxides from hydroximoyl chlorides. Chem. Comm. 2019, 55: 10587-10591.
8. Rubing Wang, Haining Lv, Shanshan Zhu, Xiaodong Ren, Song Xu, Shuanggang Ma, Yunbao Liu, Jing Qu*, Shishan Yu*. A novel and practical synthesis of CAT3: a phenanthroindolizidine alkaloid with potential in treating glioblastoma. RSC Adv. 2018, 8: 29301-29308.
9. Rubing Wang, Xiaojie Zhang, Chengsheng Chen, Guanglin Chen,Cristian Sarabia, Qiang Zhang, Shilong Zheng, Guangdi Wang, QiaoHong Chen*. Structure-activity relationship studies of 1,7-diheteroarylhepta-1,4,6-trien-3-ones with two different terminal rings in prostate epithelial cell models. Eur. J. Med. Chem. 2017, 133: 208.
10. Rubing Wang, Chengsheng Chen, Xiaojie Zhang, Guanglin Chen, Qiang Zhang, Shilong Zheng, Guangdi Wang, Qiaohong Chen*. Synthesis and evaluation of 1,7- diheteroarylhepta-1,4,6-trien-2-ones as promising anticancer agents. Eur. J. Med. Chem. 2016, 110: 16.
11. Rubing Wang, Chengsheng Chen, Xiaojie Zhang, Changde Zhang, Guanglin Chen, Qiang Zhang, Shilong Zheng, Guangdi Wang, Qiaohong Chen*. Structure-activity relationship and pharmacokinetic studies of 1,5-diheteroarylpenta-1,4-dien-3-ones: A class of curcumin-based anticancer agents. J. Med. Chem. 2015, 58: 4713-4726.

1. 菲并吲哚里西啶生物碱衍生物纳米自乳化组合物及其制备方法. 中国发明专利，授权号 CN 112353759B, 授权日期2023.4.11
2. 菲并吲哚里西啶生物碱衍生物固体脂质纳米粒组合物. 中国发明专利，授权号 CN 112870178B, 授权日期2023.1.6
3. 13a-(S)-3-新戊酰氧基-6,7-二甲氧基菲骈吲哚里西啶的晶B型. 中国发明专利，授权号 CN 110117279B, 授权日期2021.5.11
4.光学纯(S)-3-新戊酰氧基-6,7-二甲氧基菲并吲哚里西啶的制备. 中国发明专利，授权号 CN 110294752B, 授权日期2021.1.11