1. 质谱成像与空间分辨代谢组学新技术及其应用研究
2. 基于质谱技术的药物分析新方法与应用研究

1. Yue Xu#, Lingzhi Wang#, Liu Yang, Renliang Xue, Haowen Zhu, Qifeng Liu, Xueqi Lv, Ruiping Zhang, Jun Tu*, Qingce Zang*, Yinghong Wang*. Spatial metabolomics combined with transcriptomics to reveal heterogeneous metabolism and drug response in the heart of rats with heart failure. Chinese Chemical Letters, 2025: 110958.
2. Xinzhu Li#, Qingce Zang#, Ying Zhu, Xinyi Tu, Jialin Liu, Ting Li, Shiyu Zhu, Lingzhi Wang, Zeper Abliz*, Ruiping Zhang*. Database-driven spatially resolved lipidomics highlights heterogeneous metabolic alterations in type 2 diabetic mice. Analytical Chemistry, 2023, 95(51), 18691-18696.
3. Lingzhi Wang#, Qingce Zang#, Xinyi Tu, Xinzhu Li, Ting Li, Shiyu Zhu, Ruiping Zhang*, Zeper Abliz*. On-tissue chemical derivatization-enhanced spatially resolved lipidomics reveals abnormal metabolism in type 2 diabetic rat brain. Talanta, 2024, 269: 125491.
4. Shanjing Wen#, Xinyi Tu#, Qingce Zang*, Ying Zhu, Limei Li, Ruiping Zhang, Zeper Abliz. Liquid chromatography–mass spectrometry-based metabolomics and fluxomics reveals the metabolic alterations in glioma U87MG multicellular tumor spheroids versus two-dimensional cell cultures. Rapid Communications in Mass Spectrometry, 2024, 38(2): e9670.
5. Jialin Liu, Qingce Zang*, Xinzhu Li, Xinyi Tu, Ying Zhu, Lingzhi Wang, Zitong Zhao, Yongmei Song, Ruiping Zhang, Zeper Abliz*. On-tissue chemical derivatization enables spatiotemporal heterogeneity visualization of oxylipins in esophageal cancer xenograft via ambient mass spectrometry imaging. Chinese Chemical Letters, 2023: 108322.
6. Xiaowei Song#, Qingce Zang#, Jin Zhang#, Shanshan Gao, Kailu Zheng, Yan Li, Zeper Abliz*, Jiuming He*. Metabolic Perturbation Score-Based Mass Spectrometry Imaging Spatially Resolves a Functional Metabolic Response. Analytical Chemistry, 2023, 95(17): 6775-6784.
7. Limei Li#, Qingce Zang#, Xinzhu Li, Ying Zhu, Shanjing Wen, Jiuming He, Ruiping Zhang*, Zeper Abliz*. Spatiotemporal pharmacometabolomics based on ambient mass spectrometry imaging to evaluate the metabolism and hepatotoxicity of amiodarone in HepG2 spheroids. Journal of Pharmaceutical Analysis, 2023, 13(5): 483-493.
8. Lingzhi Wang#, Qingce Zang#, Ying Zhu, Jialin Liu, Xinzhu Li, Xinyi Tu, Xin Li, Zeper Abliz, Ruiping Zhang*. On-tissue chemical oxidation followed by derivatization for mass spectrometry imaging enables visualization of primary and secondary hydroxyl-containing metabolites in biological tissues. Analytical Chemistry, 2023, 95(3): 1975-1984.
9. Ying Zhu#, Qingce Zang#, Zhigang Luo, Jiuming He, Ruiping Zhang*, Zeper Abliz*. An organ-specific metabolite annotation approach for ambient mass spectrometry imaging reveals spatial metabolic alterations of a whole mouse body. Analytical Chemistry, 2022, 94(20): 7286-7294.
10. Qingce Zang#, Manjiangcuo Wang#, Ying Zhu, Lingzhi Wang, Zhigang Luo, Xin Li, Jiuming He, Ruiping Zhang*, Zeper Abliz*. Enhanced on-tissue chemical derivatization with hydrogel assistance for mass spectrometry imaging. Analytical Chemistry, 2021, 93(46): 15373-15380.
11. Qingce Zang#, Chenglong Sun#, Xiaoping Chu, Limei Li, Wenqiang Gan, Zitong Zhao, Yongmei Song, Jiuming He, Ruiping Zhang*, Zeper Abliz*. Spatially resolved metabolomics combined with multicellular tumor spheroids to discover cancer tissue relevant metabolic signatures. Analytica Chimica Acta, 2021, 1155: 338342.
12. Xiao-Chao Zhang#, Qingce Zang#, Hansen Zhao, Xiaoxiao Ma, Xingyu Pan, Jiaxin Feng, Sichun Zhang, Ruiping Zhang, Zeper Abliz*, Xinrong Zhang*. Combination of droplet extraction and pico-ESI-MS allows the identification of metabolites from single cancer cells. Analytical Chemistry, 2018, 90(16): 9897-9903.
13. Qingce Zang, Yang Gao, Luojiao Huang, Jiuming He, Sheng Lin, Hongtao Jin, Ruiping Zhang, Zeper Abliz*. Rapid and sensitive liquid chromatography–tandem mass spectrometric method for the quantitative determination of potentially harmful substance 5, 5’-oxydimethylenebis (2-4 furfural) in traditional Chinese medicine injections. Acta Pharmaceutica Sinica B, 2018, 8(2): 235-241.