1、脑卒中后修复机制及相关药物研究
2、帕金森病早发及恶化的分子机制及药物研发

1. Hu K, Ye J, Fan P, Zheng R, Wang S, Peng Y, Ruan Y, Yan X, Zhang Z*, Chu S*, Chen N*. Targeting and reprogramming microglial phagocytosis of neutrophils by ginsenoside Rg1 nanovesicles promotes stroke recovery. Bioact Mater. 2025; 47:181-197. IF=18.9
2. Wang H, Ye J, Peng Y, Ma W, Chen H, Sun H, Feng Z, He W, Li G, Chu S*, Zhang Z*, Chen N*. CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction. Autophagy. 2024;20(3):590-613. IF=14.6
3. Fan P, Lai H, Wang H, Hu K, Ruan Y, Ye J, Wang S, Peng Y, He W, Li G, Yan X, Chu S*, Zhang Z*, Chen N*. CKLF1 disrupts microglial efferocytosis following acute ischemic stroke by binding to phosphatidylserine. Cell death and differentiation. 2025 Mar 8. doi: 10.1038/s41418-025-01475-x. IF=13.7
4. Ma WY, Wu QL, Wang SS, Wang HY, Ye JR, Sun HS, Feng ZP, He WB, Chu SF*, Zhang Z*, Chen N*. A breakdown of metabolic reprogramming in microglia induced by CKLF1 exacerbates immune tolerance in ischemic stroke. J Neuroinflammation. 2023; 20(1):97. IF=9.3
5. Peng Y, Ye JR, Wang SS, He WB, Feng ZP, Sun HS, Chu SF*, Zhang Z*, Chen NH. A small molecule 20C from Gastrodia elata inhibits α-synuclein aggregation and prevents progression of Parkinson's disease. Cell Death Dis. 2023;14(9):594. IF=9.0
6. Wang SS, Peng Y, Fan PL, Ye JR, Ma WY, Wu QL, Wang HY, Tian YJ, He WB, Yan X, Zhang Z*, Chu SF*, Chen N*. Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson's disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle. Acta Pharmacol Sin. 2025; 46(2):308-325.
7. He JQ, Yuan RL, Jiang YT, Peng Y, Ye JR, Wang SS, Li LQ, Ruan Y, Li PY, Yan X, He WB, Li G, Chu SF*, Zhang Z*, Chen N*. Esculetin facilitates post-stroke rehabilitation by inhibiting CKLF1-mediated neutrophil infiltration. Acta Pharmacol Sin. 2025; 46(1):52-65.
8. Zhang Q, Wang SS, Zhang Z*, Chu SF*. PKM2-mediated metabolic reprogramming of microglia in neuroinflammation. Cell Death Discov. 2025 Apr 6;11(1):149. doi: 10.1038/s41420-025-02453-5.
9. Zhu J, Chu SF, Peng Y, Liu DD, Chen C, Jian WX, Sun HS, Feng ZP, Zhang Z*, Chen N*. Pyk2 inhibition attenuates hypoxic-ischemic brain injury in neonatal mice. Acta Pharmacol Sin. 2022; 43(4):797-810.
10. Dong YX, Chu SF, Wang SS, Tian YJ, He WB, Du YS, Wang ZZ, Yan X, Zhang Z*, Chen N*. Rg1 exerts protective effect in CPZ-induced demyelination mouse model via inhibiting CXCL10-mediated glial response. Acta Pharmacol Sin. 2022; 43(3):563-576.