天然产物功能和结构导向的药物化学研究：
1.功能天然产物的化学合成、衍生化
2.天然分子的成药性研究及新型先导物的发现
3.基于天然产物结构骨架的合成方法学研究

1. Base mediated aza-[2+1] annulation and regioselective aziridine ring-opening cascade: mild synthesis of functionalized β-amino ketones from cyclic N-sulfonyl aldimines and α-carbonyl sulfonium salts. Lei X*, Sun Y, Guo Q, Shi J*. RSC Adv. 2024, 14, 17178.
2. Synthesis of Polysubstituted Furans via Rh(II)-Catalyzed [2+3] Annulation of N-Sulfonyl-1,2,3-triazoles with Enaminones. Lei X*, Feng J, Guo Q, Li Y*, Shi J*. Org. Lett. 2023, 25, 7338.
3. Base-Promoted Formal [3+2] Cycloaddition of α‑Halohydroxamates with Carbon Disulfide to Synthesize Polysubstituted Rhodanines. Lei X*, Feng J, Guo Q, Xu C, Shi J*. Org. Lett. 2022, 24, 2837.
4. Strain-Driven Dyotropic Rearrangement: A Unified Ring-Expansion Approach to α-Methylene-γ-butyrolactones. Lei X, Li Y, Lai Y, Hu S, Qi C, Wang G*, Tang Y*. Angew. Chem. Int. Ed. 2021, 60, 4221.
5. Advances in the Total Synthesis of Xanthanolide-Type Sesquiterpenoids. Lei X, Feng J, Liu J, Tang Y*. Chem. Asian J. 2019, 14, 1888.
6. Total Synthesis of Homodimericin A. Feng J#, Lei X#, Guo Z, Tang Y*. Angew. Chem. Int. Ed. 2017, 56, 7895.
7. Total Syntheses of Periconiasins A–E. Tian Chong, Lei X, Wang Y, Dong Z, Liu G*, Tang Y*. Angew. Chem. Int. Ed. 2016, 55, 6992.
8. Rh(II)-Catalyzed Transannulation of N‑Sulfonyl-1,2,3-Triazoles with 2,1-Benzisoxazoles or 1,2-Benzisoxazoles. Lei X, Gao M, Tang Y*. Org. Lett. 2016, 18, 4990.
9. Rhodium(II)-Catalyzed Formal [3+2] Cycloaddition of N‑Sulfonyl1,2,3-triazoles with Isoxazoles: Entry to Polysubstituted 3‑Aminopyrroles. Lei X, Li L, He Y*, Tang Y*. Org. Lett. 2015, 17, 5224.