1、新药研发（治疗炎症性肠病药物和抗耐药结核感染药物的研发）
2、药物分子设计、合成及成药性研究
3、合成方法学和合成工艺研究

1. Hongyi Zhao,# Yongxin Gao,# Wei Li,# Li Sheng,# Keli Cui, Bin Wang, Lei Fu, Meng Gao, Ziyun Lin, Xiaowen Zou, Mary Jackson, Haihong Huang,* Yu Lu,* and Dongfeng Zhang.* Design, Synthesis, and Biological Evaluation of Pyrrole-2-carboxamide Derivatives as Mycobacterial Membrane Protein Large 3 Inhibitors for Treating Drug-Resistant Tuberculosis. Journal of Medicinal Chemistry, 2022, 65(15): 10534-10553.
2. Hongyi Zhao, Yanan Wu, Dongfeng Zhang,* Haihong Huang.* Mild, metal-free synthesis of 2-substituted quinazolinones from imidates and methyl 2-aminobenzoates or 2-aminobenzamides. Tetrahedron, 2022, 115, 132811.
3. Hongyi Zhao,# Shengnan Li,# Shihao Cheng, Ziyun Lin, Dongfeng Zhang,* Haihong Huang.* A mild and metal-free synthesis of chiral 2,3-dihydro-3-hydroxymethyl-1,4-benzoxazines. Tetrahedron, 2021, 93, 132304.
4. Hongyi Zhao, Bin Wang, Lei Fu, Gang Li, Haijia Lu, Yuke Liu, Li Sheng, Yan Li, Baoxi Zhang, Yang Lu, Chen Ma, Haihong Huang,* Dongfeng Zhang,* Yu Lu.* Discovery of a Conformationally Constrained Oxazolidinone with Improved Safety and Efficacy Profiles for the Treatment of Multidrug-Resistant Tuberculosis. Journal of Medicinal Chemistry, 2020, 63(17): 9316–9339.
5. Hongyi Zhao, Wenting Zhao, Shihao Cheng, Haijia Lu, Dongfeng Zhang, Haihong Huang. Efficient and stereoselective one-pot synthesis of benzo[b]oxazolo[3,4-d][1,4]oxazin-1-ones. RSC Advances., 2020, 10, 24037.
6. Hongyi Zhao,# Yu Lu,# Li Sheng, # Zishuo Yuan, Bin Wang, Weiping Wang, Yan Li, Chen Ma, Xiaoliang Wang, Dongfeng Zhang,* Haihong Huang.* Discovery of Fluorine-Containing Benzoxazinyl-oxazolidinones for the Treatment of Multidrug Resistant Tuberculosis. ACS Medicinal Chemistry Letters, 2017, 8(5): 533-537.