1. 药物分子设计与新药发现
2. 多肽化学
3. 复杂药物精准修饰合成新方法与新技术

1. Wenwu Liu#, Limeng Wu#, Zhuona Rong#, Limin Zou, Yaoguang Huang, Wenjie Liu, Chao Li, Xinhua Liu, Kangyao Zhou, Kun Hu, Jie Huang, Chaoyang Chen, Qianran Sun, Ying Zhou*, Yi Dong*, Song Song*, and Xiaocong Pang* Structure-Based Drug Design to Identify Potent, Selective, and Orally Available Cyclin-Dependent Kinase 9 Inhibitors for the Treatment of Castration-Resistant Prostate Cancer. J. Med. Chem. 2026, 69, 11335−11364.
2. Fenghua Liu#, Haixu Ren#, Mengmeng Li, Heng Xu*, Yi Dong*. Base and Ligand-Free Silver-Catalyzed Csp−H Thiolation of Terminal Alkynes with N‑Thiosuccinimides. J. Org. Chem. 2026, 91, 6294-6304.
3. Xin Yang, Heng Xu*, Yi Dong*. Site-Selective Decarboxylative C−H Carbenoid Functionalization Enabled by Pyridotriazole-3-carboxylates. Org. Lett. 2026, 28, 3843-3849.
4. Xin Yang#, Bo Mei#, Yiting Chang#, Hua Tian, Heng Xu*, Xiaoqiao Hong*, Yi Dong*. Synthesis of (Hetero)Aryl Fused 4H-Quinolizin-4-ones from N-Ts Substituted (Hetero)Arylamides and Pyridotriazoles. Org. Lett. 2025, 27, 13774-13779.
5. Menglong Lu#, Deyu Wu#, Tingting Hou#, Xin Yang, Mengmeng Li, Wenwu Liu*, Heng Xu*, Yi Dong*. Catalyst-Controlled Switchable Mono-/Di-C−H Arylation of Aromatic Amides with Arylsilanes. Org. Lett. 2025, 27, 10986-10992.
6. Hua Tian#, Xin Yang#, Ge Shi, Heng Xu*, Yi Dong*. Rhodium-catalyzed site-selective cross-couplings of indoles and pyridotriazoles through carbene insertion. Chin. Chem. Lett. 2025, 36, 110434.
7. Tongxu Su, Heng Xu*, Yi Dong*. Cp*Ir-Catalyzed C–H Arylation of 2 Pyridones and 1-Isoquinolinones with Arylsilanes. Adv. Synth. Catal. 2024, 366, 2109-2114
8. Tingting Hou#, Xin Wang#, Deyu Wu#, Xin Yang, Guang Li, Heng Xu*, Yi Dong*, Rhodium-Catalyzed C−H Arylation of Indoles with Arylsilanes at Room Temperature. J. Org. Chem. 2023, 88, 16365-16375
9. Hua Tian#, Tingting Hou#, Xin Yang, Heng Xu*, Yi Dong*. Cp*IrIII-Catalyzed C8‑Selective C−H Activation Enables Room-Temperature Direct Arylation of Quinoline N‑Oxides with Arylsilanes. J. Org. Chem. 2023, 88, 16365-16375.
10. Yiting Chang, Tingting Hou, Yi Dong*, Heng Xu*. Rhodium-Catalyzed Regioselective Synthesis of N-Secondary Alkyl Indoles via Intermolecular Cyclization of N-Nitrosoanilines and Unsymmetrical Alkynes. Synthesis 2023, 55, 3969-3980.
11. Wenjun Yu#, Xilei Xie#, Yao Ma#, Shiping Fang, Yi Dong*, Gang Liu*. Identification of 1,4-Benzodiazepine-2,5-dione Derivatives as Potential Protein Synthesis Inhibitors with Highly Potent Anticancer Activity. J. Med. Chem. 2022, 65, 14891-14915
12. Deyu Wu, Zhengqiang Liu, Yiting Chang, Jiajing Chen, Haixiang Qi, Yi Dong*, Heng Xu*. Cp*CoIII-catalyzed formal [4 + 2] cycloaddition of 2-phenyl-1H-imidazoles to afford imidazo[1,2-c] quinazoline derivatives. Org. Biomol. Chem. 2022, 20, 4993
13. Yi Dong#, Rong Fu#, Jiajing Chen, Kehui Zhang, Ming Ji, Mingjin Wang, Huimin Jiang, Wei Ye, Jinping Hu, Yan Li, Jing Jin*, Xiaoguang Chen*, Heng Xu*. Discovery of Benzocyclic Sulfone Derivatives as Potent CXCR2 Antagonists for Cancer Immunotherapy. J. Med. Chem. 2021, 64, 16626-16640.
14. Yi Dong#, Bo Mei#, Xue-Peng Zhang*, Heng Xu*. Selective Gram-Scale C−H Carbenoid Functionalization of N Sulfonylarylamides with a Rhodium Catalyst. J. Org. Chem. 2021, 86, 11660-11672
15. Yao Ma#, Xueyuan Li#, Yameng Pei#, Jingjia Ye, Xiduan Wei, Jingshu Yang, Guangxu Si, Jingyuan Tian, Yi Dong*, Gang Liu*. Identification of benzofused five-membered sultams, potent dual NOD1/NOD2 antagonists in vitro and in vivo. Eur. J. Med. Chem. 2020, 204, 112575.
16. Yao Ma#, Jingshu Yang#, Xiduan Wei#, Yameng Pei, Jingjia Ye, Xueyuan Li, Guangxu Si, Jingyuan Tian, Yi Dong*, Gang Liu*. Nonpeptidic quinazolinone derivatives as dual nucleotide-binding oligomerization domain-like receptor 1/2 antagonists for adjuvant cancer chemotherapy. Eur. J. Med. Chem. 2020, 207, 112723.
17. Xueyuan Li#, Xiao Hu#, Zijie Liu, Jingshu Yang, Bo Mei, Yi Dong*, Gang Liu*. Ruthenium-Catalyzed Selectively Oxidative C−H Alkenylation of N Acylated Aryl Sulfonamides by Using Molecular Oxygen as an Oxidant. J. Org. Chem. 2020, 85, 5916-5926.
18. Yi Dong#, Jiajing Chen#, Yunjian Cui, Liangliang Bao, Heng Xu*. Cp*RhIII-Catalyzed Sulfonamide-Directed Ortho Arene C−H Carbenoid Functionalization with Pyridotriazoles. Org. Lett. 2020, 22, 772-775.
19. Qiang Wei#, Yao Ma#, Yi Dong*, Gang Liu*. Copper-Catalyzed Direct C(sp3)−H Alkoxylation to Access Quaternary α Alkoxylated Amino Acid Derivatives. Org. Lett. 2020, 22, 5796-5800.