2005进入中国医学科学院药物研究所工作至今，先后任助理研究员、副研究员，主要从事创新药物研发、有机合成等方面的工作。近年来，主持或参与科研项目共10余项，其中主持国家自然青年基金项目1项，北京市自然科学基金1项，药物所基本科研业务费3项，参与的项目包括国家科技重大专项2项，中国医学科学院医学与健康科技创新工程2项，国自然面上项目3项等。近年来发表SCI论文10余篇，申请发明专利10余项，其中五项获得授权。

药物分子设计与合成 针对肿瘤、糖尿病和精神神经系统等疾病领域的生物大分子靶标，设计合成新结构的小分子化学实体，寻找干预疾病信号传导通路的先导结构，经结构修饰和优化，发现具有潜在治疗作用的侯选药物。

1. Discovery of 2-Ethoxy-5-isobutyramido-N-1-substituted Benzamide Derivatives as Selective Kv2.1 Inhibitors with in Vivo Neuroprotective Effects, Jie Zhou, Weiping Wang, Dong Liu, Shaofeng Xu, Xue Wang, Xinyuan Zhang, Xiaoyu Wang, Yan Li, Li Sheng, Xiaoliang Wang, Bailing Xu, Journal of Medicinal Chemistry, 2024, 67, 213-233.
2. Discovery of Quinazoline-2,4(1H,3H) dione Derivatives Containing a Piperizinone Moiety as Potent PARP-1/2 Inhibitors-Design, Synthesis, in Vivo Antitumor Activity, and X ray Crystal Structure Analysis, Jie Zhou, Tingting Du, Xiaoyu Wang, Haiping Yao, Jialing Deng, Yan Li, Xiaoguang Chen, Li Sheng, Ming Ji, and Bailing Xu, Journal of Medicinal Chemistry, 2023, 66, 14095-14115.
3. Discovery of Quinazoline-2,4(1H,3H) dione Derivatives Containing 3-Substituted Piperizines as Potent PARP-1/2 Inhibitors―Design, Synthesis, in Vivo Antitumor Activity, and X ray Crystal Structure Analysis，Jie Zhou, Ming Ji, Xiaoyu Wang, Hailong Zhao, Ran Cao, Jing Jin, Yan Li, Xianhong Chen, Li Sheng, Xiaoguang Chen, and Bailing Xu, Journal of Medicinal Chemistry, 2021, 64: 16711-16730.
4. Discovery of N-arylsulfonyl-indole-2-carboxamide Derivatives as Potent, Selective, and Orally Bioavailable Fructose-1,6-Bisphosphatase Inhibitors―Design, Synthesis, in Vivo Glucose Lowering Effects, and X-ray Crystal Complex Analysis, Jie Zhou, Jianbo Bie, Xiaoyu Wang, Quan Liu, Rongcui Li, Hualong Chen, Jinping Hu, Hui Cao, Wenming Ji, Yan Li, Shuainan Liu, Zhufang Shen, Bailing Xu, Journal of Medicinal Chemistry, 2020, 63, 10307-10329.
5. Discovery of Quinazoline-2,4(1H,3H)-dione Derivatives as Novel PARP1/2 Inhibitors: Design, Synthesis and Their Antitumor Activity, Zhou jie, Ji Ming, Yao Haiping, Cao Ran, Zhao Hailong, Wang Xiaoyu, Chen Xiaoguang, Xu Bailing, Organic & Biomolecilar Chemistry, 2018, 16, 3189-3202.
6. Discovery of 2-Substituted 1H-Benzo[d]imidazole-4-carboxamide Derivatives as Novel Poly(ADP-ribose)polymerase-1 Inhibitors with in Vivo Anti-tumor Activity, Zhou jie, Ji Ming, Zhu Zhixiang, Cao Ran, Chen Xiaoguang, Xu Bailing, European Journal of Medicinal Chemistry, 2017,132: 26-41.
7. 3-氨基苯甲酰胺衍生物PARP-1抑制剂的设计合成及活性评价, 周洁, 朱枝祥, 季鸣, 曹冉, 陈晓光, 徐柏玲,中国药物化学杂志, 2016, 26, 165-174.
8. Synthesis and Biological Evaluation of Novel Quinoxalinone-based HIV-1 Reverse Transcriptase Inhibitors, Jie Zhou, Mingyu Ba, Bo Wang, Haibo Zhou, Jianbo Bie, Decai Fu, Yingli Cao, Bailing Xu, Ying Guo, Medicinal Chemistry Communication, 2014, 5, 441-444.
9. Synthesis and Antiproliferative Evaluation of Novel Benzoimidazole-contained Oxazole-Bridged Analogs of Combretastatin A-4, Jie Zhou, Jing Jin, Yi Zhang, Yuwen, Yin, Xiaoguang Chen, Bailing Xu, European Journal of Medicinal Chemistry, 2013, 68, 222-232.
10.氮杂吲哚类PARP-1抑制剂的合成及活性评价，药学学报，周洁, 朱枝祥, 陈晓光, 徐柏玲, 2013, 48, 1792-1799.
11. An in silico Investigation of Kv2.1 Potassium Channel: Model Building and Inhibitors Binding Sites Analysis, Xiaoyu Wang, Xinyuan Zhang, Jie Zhou, Weiping Wang, Xiaoliang Wang, and Bailing Xu, Molecular Informatics, 2023, e202300072.
12. Discovery of N Arylsulfonyl-Indole-2-Carboxamide Derivatives as Galectin 3 and Galectin 8 C Terminal Domain Inhibitors, Haoming Zhang, Xiaoyu Wang, Yanjun Wan, Liheng Liu, Jie Zhou, Pingping Li, and Bailing Xu, ACS Medicinal Chemistry Letter, 2023, 14, 1257-1265.
13. Discovery of Novel Indole Derivatives as Fructose-1,6- bisphosphatase Inhibitors and X ray Cocrystal Structures Analysis, Xiaoyu Wang, Rui Zhao, Wenming Ji, Jie Zhou, Quan Liu, Linxiang Zhao, Zhufang Shen, Shuainan Liu, and Bailing Xu, ACS Medicinal Chemistry Letter, 2022, 13, 118-127.
14. Discovery of 3, 6-Disubstituted Isobenzofuran-1(3H)-ones as Novel Inhibitors of Monoamine Oxidases, Kaiyue Liu, Shiqi Zhou, Jie Zhou, Ruxue Bo, Xiaoyu Wang, Tong Xu, Yuhe Yuan, Bailing Xu, Bioorganic & Medicinal Chemistry Letter, 2022, 67, 128748-128755.

1.吲哚类化合物及其制备方法、药物组合物和用途，徐柏玲、陈晓光、崔国楠、来芳芳、周洁、季鸣、王晓宇、杜婷婷、李陵、金晶；专利授权日2022-9-16，专利号：ZL201810453950.8。
2.芳酰胺类Kv2.1抑制剂及其制备方法、药物组合物和用途, 徐柏玲、王晓良、周洁、王伟平、刘东、郭婷婷、王雪、冯楠、陈华龙、徐少锋、李江、王玲；专利授权日：2022-7-22，专利号：ZL 201810307478.7。
3. 喹唑啉酮类PARP-1抑制剂及及其制备方法，药物组合物和用途, 徐柏玲、陈晓光、姚海平、季鸣、金晶、周洁、王珂、赵大龙；专利授权日：2022-4-15，专利号：ZL201680080100.7。
4. 含有哌嗪酮的喹唑啉酮类PARP-1/2抑制剂及其制备方法、药物组合物和用途；徐柏玲、陈晓光、周洁、季鸣、姚海平、周秦；专利授权日：2020-5-7，专利号：ZL201610108263.3。
5. N-酰基磺酰胺类FBPase抑制剂、其制备方法、药物组合物及用途；徐柏玲、申竹芳、别建波、穆永钊、刘率男、周洁、李彩娜、曹冉、环弈、孙淑娟，专利授权日：2020-10-9，专利号：ZL 2016 1 0105864.9。