1. 天然产物来源的活性成分功能研究(抗糖化,维持骨稳态等)。
2. 分子与细胞水平的药理学评价新方法建立。
3. 创新药候选物的临床前研究及作用机制研究。

职 称:副研究员
所属科室:药理学研究室
导师类别:
联系方式:Wangyuchen@imm.ac.cn
所属重点实验室:“创新药临床前研发药代-药效关键技术”北京市重点实验室
第一作者:
1. Wang, Y., Lu, S. C., Wen, H., Zhao, C., Jiang, Y., & Cui, H. 2024. 'A CuSO4/Bicinchoninic acid/Reducing sugar based stable and non-ROS catalyst system for the CuAAC reaction in bioanalysis'. Bioorganic chemistry, 150, 107557.
2. Wang, Y., Jia, S., Chen, Y., Liao, X., Jie, R., Jiang, L., Wang, T., Wen, H., Gan, W., & Cui, H. 2024. 'Taking advantage of the interaction between the sulfoxide and heme cofactor to develop indoleamine 2, 3-dioxygenase 1 inhibitors'. Bioorganic chemistry, 148, 107426.
3. Wang Y, Jia S, Yu Z, Wen H, Cui H. 2021. ‘Insights Into the Detection Selectivity of Redox and Non-redox Based Probes for the Superoxide Anion Using Coumarin and Chromone as the Fluorophores’. Front Chem. 25(9):753621.
4. Wang, Y.; Liu, X.; Zou, X.; Wang, S.; Luo, L.; Liu, Y.; Dong, K.; Yao, X.; Li, Y.; Chen, X.; Sheng, L. 2021. 'Metabolism and Interspecies Variation of IMMH-010, a Programmed Cell Death Ligand 1 Inhibitor Prodrug'. Pharmaceutics, 13, 598.
5. Wang, Y, Li, Z, Zhang, Z, Chen, X. 2021. 'Identification ACTA2 and KDR as key proteins for prognosis of PD‐1/PD‐L1 blockade therapy in melanoma'. Anim Models Exp Med. 00: 1-13.
6. Wang, Y., J. Han, Y. Xu, Y. Gao, H. Wen, and H. Cui. 2020. 'Taking advantage of the aromatisation of 7-diethylamino-4-methyl-3,4-dihydrocoumarin in the fluorescence sensing of superoxide anion', Chem Commun (Camb), 56: 9827-29.
7. Wang, Y., H. Tian, W. Cai, Z. Lian, D. Bhavanasi, C. Wu, T. Sato, M. Kurokawa, D. Wu, L. Fu, H. Wang, H. Shen, D. Liang, and J. Huang. 2018. 'Tracking hematopoietic precursor division ex vivo in real time', Stem Cell Res Ther, 9: 16.
8. Wang, Y., C. Qiu, and Q. Cui. 2015. 'A Large-Scale Analysis of the Relationship of Synonymous SNPs Changing MicroRNA Regulation with Functionality and Disease', Int J Mol Sci, 16: 23545-55.
9. 王雨辰,陈越,季鸣,薛妮娜,陈晓光,STAT3靶点抑制剂Bt354抗前列腺癌作用及其分子机制研究,药学学报,54: 1851 −1857.
通讯作者:
1. Wang, T., Liao, X., Zhao, X., Chen, K., Chen, Y., Wen, H., Yin, D., Wang, Y., Lin, B., Zhang, S., & Cui, H. 2024. 'Rational design of 2-benzylsulfinyl-benzoxazoles as potent and selective indoleamine 2,3-dioxygenase 1 inhibitors to combat inflammation'. Bioorganic chemistry, 152, 107740.
2. Wang, W., Dong, G., Yang, Z., Li, S., Li, J., Wang, L., Zhu, Q., & Wang, Y. 2024. 'Single-cell analysis of tumor microenvironment and cell adhesion reveals that interleukin-1 beta promotes cancer cell proliferation in breast cancer'. Animal models and experimental medicine, 10.1002/ame2.12445. Advance online publication.
3. Chen, Y.; Gao, Y.; He, Y.; Zhang, G.; Wen, H.; Wang, Y.; Wu, Q.-P.; Cui, H.2021. 'Determining Essential Requirements for Fluorophore Selection in Various Fluorescence Applications Taking Advantage of Diverse Structure–Fluorescence Information of Chromone Derivatives'. Journal of Medicinal Chemistry, 64 (2), 1001-1017.
4. Xu, Y.; Qi, N.; Wen, H.; Zhang, G.; Wang, Y.; Cui, H. 2021. 'Synthesis and evaluation of benzenesulfonic acid derivatives as human neutrophil elastase (hNE) inhibitors'. Medicinal chemistry research, 30 (2), 387-398.
5. 刘洋,王欢欢,侯雪莹,王雨辰,融入思政元素的新药研发PBL课程设计,基础医学与临床, 2023,43 : 91-94.