1994.09--1999.07 济宁医学院，学士
1999.09--2002.07 天津医科大学，硕士
2002.07--2005.08 中国科学院电工研究所，实习研究员
2005.09--2008.07 北京协和医学院，博士
2008.09—至今中国医学科学院药物所，助理研究员，副研究员

神经精神系统疾病发病新机制、新靶点研究以及新药研发；炎症免疫相关疾病的机制研究及治疗药物研发；肠道菌群在多种疾病进程中的机制研究。

1. Gut microbiota mediates the absorption of FLZ, a new drug for Parkinson’s disease treatment. Shang JM, Ma SR, Zang CX, Bao XQ*, Wang Y,* Zhang D*. Acta Pharmaceutica Sinica B. Accepted. (IF: 11.413)
2. Autoimmune polyendocrine syndrome induced by immune checkpoint inhibitors: a systematic review. Zhao Z, Wang X, Bao XQ, Ning J, Shang M, Zhang D*. Cancer Immunol Immunother, 2020. (IF: 6.962)
3. CXCR2 antagonism promotes oligodendrocyte precursor cell differentiation and enhances remyelination in a mouse model of multiple sclerosis. Wang L, Yang HY, Zang CX, Dong Y, Shang JM, Chen JH, Wang Y, Liu H, Zhang ZH, Bao XQ*, Xu H*, Zhang D*. Neurobiol Dis, 2020. (IF: 5.991)
4. Novel phloroglucinol derivative Compound 21 protects experimental autoimmune encephalomyelitis rats via inhibiting Th1/Th17 cell infiltration. Zhao Z, Bao XQ, Zhang Z, Li F, Liu H, Zhang D*. Brain Behav Immun, 2020. (IF: 7.217)
5. Discovery of coumarinMannich base derivatives as multifunctional agents against monoamine oxidase B and neuroinflammation for the treatment of Parkinson's disease. Deng Tao, Yue Wang, Xiu-Qi Bao, Bei-Bei Yang, Fan Gao, Lin Wang, Dan Zhang*, Li Li*. European journal of medicinal chemistry, 2019. (IF：6.514)
6. Phloroglucinol derivative compound 21 attenuates cuprizone-induced multiple sclerosis mice through promoting remyelination and inhibiting neuroinflammation. Zhao Z, Bao XQ, Zhang Z, Liu H, Zhang D*. Sci China Life Sci, 2019. (IF: 6.038)
7. A Novel Synthetic Derivative of Phloroglucinol Inhibits Neuroinflammatory Responses Through Attenuating Kalirin Signaling Pathway in Murine BV2 Microglial Cells. Zang CX, Yang HY, Wang L, Wang Y, Bao XQ, Wang XL, Zhang D*. Mol Neurobiol, 2018. (IF:5.592)
8. Integrin CD11b mediates α-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway. Liyan Hou#, Xiuqi Bao#, Caixia Zang, Hanyu Yang, Fuqiang Sun, Yuning che, Xuefei Wu, Shao Li, Dan Zhang*, Qingshan Wang*. Redox Biol, 2018. (IF:11.799)
9. FLZ Attenuates α-Synuclein-Induced Neurotoxicity by Activating Heat Shock Protein 70. Bao XQ, Wang XL, Zhang D*. Mol Neurobiol, 2017. (IF:5.592)
10. A Novel Parkinson's Disease Drug Candidate with Potent Anti-neuroinflammatory Effects through the Src Signaling Pathway. Wang YD#, Bao XQ#, Xu S, Yu WW, Cao SN, Hu JP, Li Y, Wang XL, Zhang D*, Yu SS*. J Med Chem, 2016. (IF: 7.446)
11. Inhibition of Src tyrosine kinase activity by squamosamide derivative FLZ attenuates neuroinflammation in both in vivo and in vitro Parkinson's disease models. Tai W, Ye X, Bao X, Zhao B, Wang X, Zhang D*. Neuropharmacology, 2013. (IF: 5.25)
12. Li Z#, Bao X#, Bai X, Zhang G, Wang J, Zhu M, Wang Y, Shang J, Sheng C, Zhang D*, Wang Y*. Design, Synthesis, and Biological Evaluation of Phenol Bioisosteric Analogues of 3- Hydroxymorphinan. Sci Rep. 2019 Feb 19;9(1):2247. (Co-first author) (IF: 4.011)
13. Bao XQ, Wang L, Yang HY, Hou LY, Wang QS*, Zhang D*. Induction of glial cell line-derived neurotrophic factor by the squamosamide derivative FLZ in astroglia has neuroprotective effects on dopaminergic neurons. Brain Res Bull, 2020 Jan;154:32-42. (IF: 3.37)
14. Yu WW#, Cao SN, Zang CX, Sun H, Bao XQ*, Zhang D*. Heat shock protein 70 suppresses neuroinflammation induced by α-synuclein in rat primary astrocytes. Mol Cell Neurosci. 2018;86:58-64. (IF:3.312)

1. 藏红花色素类组合物在制备用于治疗帕金森症的药物中的应用。姚新生, 张丹, 于洋, 鲍秀琦, 臧彩霞, 盛婵娟。专利号:ZL201810884030.1, 授权日2020.4.28。
2. 藏红花色素类化合物及其用途。姚新生, 于洋, 张丹, 倪阳，鲍秀琦, 李林, 臧彩霞, 高昊，郑远鹏。专利号：ZL201610284974.6。授权日期：2017.12.29。2017255363（澳大利亚），2018-556352（日本），16/097,166（美国），17788553.0（欧专局）。
3. 组合物藏红花色素类活性部位及其用途。姚新生，张丹，于洋，鲍秀琦，倪阳，臧彩霞，高昊，郑远鹏。专利号：ZL201610284549.7。授权日期：2017.03.08；2017255362（澳大利亚），2018-556347（日本），16/097,247（美国），17788552（欧专局）。
4. 间苯三酚类衍生物及其在治疗神经退行性疾病中的用途。庾石山,张丹,王亚丹,鲍秀琦, 屈晶, 徐嵩, 泰文娇, 武良玉。专利号：ZL201480026162.0，授权日2018.7.20。
5. 咪唑酮-吗啡喃及其制备方法和应用。张丹, 王玉成, 李子强, 鲍秀琦, 白晓光, 张国宁, 王菊仙, 周磊, 李强, 郑远鹏, 臧彩霞。专利号：ZL201610194651.8，授权日期： 2017.05.10。
6. 香豆素曼尼希碱的合成及其在防治神经退行性疾病中的用途。李莉,王琳,张丹, 鲍秀琦, 高琦, 臧彩霞, 郑远鹏。申请号：201611177885.8。申请日：2016.11.01。
7. 藏红花色素类组合物在制备治疗或改善抑郁症的药物中的应用。姚新生, 张丹, 于洋, 鲍秀琦, 鲁丹, 臧彩霞, 盛婵娟。申请号：201711020810.3。申请日：2017.10.26。
8. 芬乐胺晶B型、制备方法和其组合物与用途。吕扬，杨世颖，刘耕陶，张丹，鲍秀琦，谢平。申请号：2017105609838。申请日：2017.9.18。
9. 芬乐胺晶G型、制备方法和其组合物与用途。吕扬，杨世颖，刘耕陶，张丹，鲍秀琦，谢平。申请号：2017105607033。申请日：2017.9.18。