刘晓宇，博士，副研究员。2013年毕业于北京协和医学院，获得药物化学博士学位。主要研究方向为适药天然产物、结构简化物的合成以及构效关系的研究、手性药物及中间体的催化合成及方法学研究。主持国自然青年基金1项、药物所基本科研业务费1项，参与国家科技重大专项，国家自然科学基金面上项目等。共发表论文30余篇，申请专利12项，获授权专利5项。

1．活性天然产物的全合成及结构修饰
2．创新药物的研发
3．手性药物及中间体的催化合成及方法学研究

1. Xiaoyu Liu (#), Qianqian Du (#), Caiping Tian, Mei Tang , Yingjun Jiang , Yong Wang , Yang Cao , Zhe Wang , Zhenwei Wang , Jing Yang, Yan Li *, Xiaozhen Jiao, Ping Xie*. Discovery of CAPE derivatives as dual EGFR and CSK inhibitors with anticancer activity in a murine model of hepatocellular carcinoma. Bioorganic Chemistry, 2021, 107, 104536.
2. Xiaoyu Liu; Haidong Deng; Yingjun Jiang; Yang Cao; Zhe Wang; Xiaozhen Jiao; Ping Xie ; Total synthesis of (±) commiphoranes C–D and their epimers, Organic & Biomolecular Chemistry, 2022, 20(10): 2102-2108.
3. Xin-Yue Suo (#), Xiao-Yu Liu (#), Xiao-Wei Liu, Xiao-Xiu Li, Ting-Ting Zhu, Teng-Fei Ji*, Bo Liu*. Four new polyprenylated acylphloroglucinol derivatives from Hypericum beanie. J. Asian Nat. Prod. Res. 2022; 24 (11): 1008-1017.
4. Kailu Zheng, Mei Tang, Haidong Deng, Siqi, Liu, Xiaoyu Liu*, Yan Li*. The antitumor activity and mechanisms of action caffeic acid phenethyl ester derivative PEC01 in mouse G422 glioma. Acta Pharmaceutica Sinica, 2022, 57( 4 ): 1063−1072.
5. Xiaoyu Liu(#), Panpan Chen (#), Xiaoyu Li, Mingyu Ba, Xiaozhen Jiao*, Ying Guo*, Ping Xie. Design, synthesis and biological evaluation of substituted (+)-SG-1 derivatives as novel anti-HIV agents. Bioorganic & Medicinal Chemistry Letters, 2018, 28(10): 1699-1703.
6. Xiaoyu Liu(#), Xiaoyu Li, Hongguang Yang, Xiang Shi, Feilong Yang, Xiaozhen Jiao* and Ping Xie. Concise and efficient synthesis of eliglustat. Synthetic communications, 2018, 48(5): 594-599.
7. Xiaoyu Liu(#), Xiaoyu Li, Feilong Yang, Yan Li, Xiaozhen Jiao * and Ping Xie. Design, synthesis of a novel 4-O-methylsaucerneol analogue LXY7824 as potent HIF-1 inhibitor and anti-cancer agent. Journal of Asian Natural products Resarch, 2018, 20(6): 545-558.
8. Xiaoyu Liu(#), Chengsen Tian, Xiaozhen Jiao, Xiaoyu Li, Hongguang Yang, Yangyang Yao and Ping Xie*. A practical synthesis of chiral tricyclic cyclopenta[b]benzofuran, a key intermediate of Beraprost. Org. Biomol. Chem., 2016, 14(32): 7715-7721.
9. Liwei Lang(#), Xiaoyu Liu(#), Yan Li, Qing Zhou, Ping Xie, Chunhong Yan*, Xiaoguang Chen*. A synthetic manassantin a derivative inhibits hypoxia-inducible factor 1 and tumor growth. PLos One, 2014, 9(6): 1-9.
10. Yonghui Ma (#); Xiaoyu Liu (#); Bo Liu, Pingping Li, Xinyue Suo, Tingting Zhu, Tengfei Ji*, Jin Li,* Xiaoxiu Li*. Hyperacmosin R, a New Decarbonyl Prenylphloroglucinol with Unusual Spiroketal Subunit from Hypericumacmosepalum. Molecules, 2022, 27, 5932.

1. 三白脂素结构简化物，其制法和其药物组合物与用途。谢平，陈晓光，焦晓臻，刘晓宇，李燕，张翼，郎立伟，王丽萍，李人则，2016/3/9，中国， ZL201110141751.1
2. 一种制备伊力格鲁司他的方法。谢平，刘晓宇，焦晓臻，李晓宇，杨红光，施翔，杨飞龙， 2021/1/12，中国， ZL201810305457.1
3. 木脂素类天然产物4-O-甲基三白草醇的结构简化物，其制法和其药物组合物与用途。李燕，谢平，刘晓宇，焦晓臻，杜倩倩，李晓宇，杨飞龙，2022/3/15，中国，ZL201711282043.3
4. 咖啡酸苯乙酯类衍生物，其制法和其药物组合物与用途。谢平，李燕，焦晓臻，刘晓宇，唐梅，王勇，杜倩倩，2022/9/16，中国，ZL201910583291.1
5. 2,3-二氢萘并[呋喃]-4,9-二酮类化合物及其制备方法和用途。谢平，陈晓光，焦晓臻，施翔，刘晓宇，薛妮娜，季鸣，杜婷婷，王振伟，2023/7/28，中国，ZL 2019 1 0311646.4
6. 木脂素类衍生物及其制法和其药物组合物与用途。谢平，李燕，焦晓臻，刘晓宇，姜英俊，郑凯露，邓海东，王哲，王振伟，曹泱，吴媛媛，申请号：202110277262.2
7. 抗肾纤维化天然产物Commiphorane C 异构体其制法与用途。谢平，焦晓臻，刘晓宇，姜英俊，王振伟，吴媛媛，曹泱，王哲，李文萱，王苑，马波，申请号：202111623518.7
8. BysspectinA 衍生物、其制备方法及其药物用途。焦晓臻，葛广波，吴媛媛，谢平，刘晓宇，宋云清，张雅，马波，李文萱，王苑，申请号：202210173634.1
9. 一种咖啡酸类衍生物及其制法和药物组合物与用途。谢平，季鸣，焦晓臻，杜婷婷，刘晓宇，金晶，王哲，李文萱，申请号：202210701582.0
10．2-苯基-4-酰基苯并呋喃类化合物、其制备及其用途。焦晓臻，葛广波，谢平，刘晓宇，李文萱，吴媛媛，张雅，胡丹阳，申请号：202211359718.0
11. 一种脂肪胺羧酸五味子酚酯及其制备方法和应用以及一种抗抑郁症药物。王刚，吉腾飞，李磊，刘晓宇，张婉君，谢平，焦晓臻，杜静，申请号：202311237697X
12. 芳基烯酸五味子酚酯在制备治疗抑郁症药物中的应用及所制备的抗抑郁药物。吉腾飞，王刚，刘晓宇，杜静，谢平，李磊，朱婷婷，张婉君，焦晓臻，申请号：2023112216487