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副研究员

康洁

职 称:副研究员

所属科室:天然药物化学研究室

导师类别:硕士生导师

联系方式:jiekang@imm.ac.cn

所属重点实验室:天然药物活性物质与功能国家重点实验室

个人简介

工作经历
2012/09–今,中国医学科学院药物研究所,天然产物化学室,副研,硕导
2008/09–2012/06 美国阿肯色大学儿童营养研究中心,生理系,博士后
2006/09–2008/08 北京大学医学部药学院,天然产物化学系,博士后
1999/09–2001/08 中国医学科学院药物研究所,天然产物化学室,实习研究员
教育背景 2001/09-2006/06 中国协和医科大学,药物化学专业,博士学位
1995/09-1999/06 同济医科大学,药学专业,理学学士

研究方向

1.天然产物活性物质的寻找与发现
(1)抗炎、抗肿瘤、抗糖尿病、及代谢性疾病的活性天然产物的发现与结构修饰。
(2)药用真菌活性成分的研究。
(3)液质分析的研究。
2.常用中药(单方和复方)药效物质基础研究
针对所要研究的中药(单方和复方)在临床上所治疗病症,选择相应的药理筛选指标,进行高通量筛选,以确定该单方或复方的药效物质和药效物质群。通过HPLC, HPLC-NMR, HPLC-MS,确定化合物类型,结合快速分离方法,得到单体化合物,并确定化合物结构。研究复方的化学组成与药效相关性,确定活性化合物。提供新药研究先导化合物。

发表论文

1. Water-soluble alkaloids isolated from Portulaca oleracea L. Jia Fuequa, Hongqing Wangequa, Chaoxuan Dong, Chuchu Xi, Jun Xie, Shengtian Lai, Ruoyun Chen, Jie Kang*. Bioorg Chem, 2021, 113: 105023.
2. The racemic trimeric quinone and polycyclic quinones isolated from the aerial parts of Morinda umbellata L. Changkang Li, Chaoxuan Dong, Jia Fu, Jun Xie, Shengtian Lai, Hongqing Wang, Ruoyun Chen, Jie Kang*. Phytochemistry, 2021, 183: 112622.
3. Inhibition of IL-6 expression by lignans and other constituents isolated from Schefflera rubriflora C. J. Tseng & G. Hoo. Fenghua Li, Zhengyu Cao, Hongqing Wang, Changkang Li, Jia Fu, Jun Xie, Baoming Li, Ruoyun Chen, Jie Kang*. Fitoterapia, 2020, 140: 104417.
4. Eight new glycosides with hepatoprotective activity isolated from the aerial parts of Morinda parvifolia. Xianming Su, Lili, Hua Sun, Fan Zhang, Changkang Li, Fenghua Li, Hongqing Wang, Baoming Li, Ruoyun Chen, Jie Kang*. Bioorg Chem. 2019, 87: 867-875.
5. Cytotoxic quinones from the aerial parts of Morinda umbellata L. Changkang Li, Xianming Su, Fenghua Li, Jia Fu, Hongqing Wang, Baoming Li, Ruoyun Chen, Jie Kang*. Phytochemistry, 2019, 167: 112096.
6. Anti-inflammatory terpenes from Schefflera rubriflora C. J. Tseng & G. Hoo with their TNF-α and IL-6 inhibitory activities. Fenghua Li, Jian Zhang, Mingbao Lin, Xianming Su, Changkang Li, Hongqing Wang, Baoming Li, Ruoyun Chen, Jie Kang*. Phytochemistry, 2019, 163: 23-32.
7. Anti-inflammatory glycosides isolated from the aerial parts of Morinda parvifolia. Xianming Su, Jian Zhang, Fenghua Li, Changkang Li, Jia Fu, Baoming Li, Ruoyun Chen, Jie Kang*, Phytochem Lett, 2019, 33: 55-60.
8. Glycosides of naphthohydroquinones and anthraquinones isolated from the aerial parts of Morinda parvifolia Bartl. ex DC (Rubiaceae) increase p53 mRNA expression in A2780 cells. Xianming Su, Jian Zhang, Changkang Li, Fenghua Li, Hongqing Wang, Haifeng Gu, Baoming Li, Ruoyun Chen, Jie Kang*. Phytochemistry, 2018, 152: 97-104.
9. A new nortriterpenoid, a sesquiterpene and hepatoprotective lignans isolated from the fruit of Schisandra chinensis. Fenghua Li, Ting Zhang, Hua Sun, Haifeng Gu, Hongqing Wang, Xianming Su, Changkang Li, Baoming Li, Ruoyun Chen, Jie Kang*. Molecules, 2017, 22, 1931.
10. Phenolic acid profiling, antioxidant, and anti-Inflammatory activities, and miRNA regulation in the polyphenols of 16 blueberry samples from China. Xianming Su, Jian Zhang, Hongqing Wang, Jing Xu, Jiuming He, Liying Liu, Ting Zhang, Ruoyun Chen, Jie Kang*, Molecules, 2017, 22: 312.
11. Isolation, modification, and aldose reductase inhibitory activity of rosmarinic acid derivatives from the roots of Salvia grandifolia. Jie Kang, Yanbo Tang, Quan Liu, Nan Guo, Jian Zhang, Zhiyan Xiao, Ruoyun Chen*, Zhufang Shen*. Fitoterapia, 2016, 112: 197-204.
12. Naphthohydroquinones, naphthoquinones, anthraquinones, and a naphthohydroquinone dimer isolated from the aerial parts of Morinda parvifolia and their cytotoxic effects through up-regulation of p53. Jie Kang, Peng Zhang, Zengping Gao, Jian Zhang, Yan Zheng, Hongqing Wang, Ruoyun Chen*. Phytochemistry, 2016, 130:144-151.
13. Isolation and bioactivity of diterpenoids from the roots of Salvia grandifolia. Jie Kang, Li Li, Dingding Wang, Hongqing Wang, Chao Liu, Baoming Li, Yu Yan, Lianhua Fang, Guanhua Du, Ruoyun Chen*. Phytochemistry, 2015, 116: 337-348.
14. Phenolic acids of the two major blueberry species in the US market and their antioxidant and anti-inflammatory activities. Jie Kang, Keshari M. Thakali, Gitte S. Jensen, Xianli Wu*. Plant Foods Hum Nutr, 2015, 70 (1): 56-62.

专著

Ganoderma and Health. Biology, Chemistry and Industry. Zhibin Lin and Baoxue Yang (主编). Ruoyun Chen and Jie Kang (编者). Springer, 2019.
2. 中国食用药用真菌化学. 陈若芸 (主编),康洁 (副主编). 上海科学技术文献出版社, 2016.
3. Blueberries: Major phytochemicals and potential health effects in cardiovascular diseases. Carlo Tuberoso (主编). Xianli Wu and Jie Kang (编者). Nova Publisher, 2012.
4. Soy: Nutrition, Consumption and Health. Aamir Ahmad (主编). Xianli Wu, Jie Kang (编者) and Keshari M. Thakali. Nova Publisher, 2012.
5. Phytochemicals - Bioactivities and Impact on Health. Iraj Rasooli (主编). Xianli Wu and Jie Kang (编者). INTECH Publisher, 2011.

专利

1. 一类具有镇痛作用的钠离子通道1.7抑制剂. 曹征宇,陈若芸,赵芳,李熙莼,康洁,潘锡平.专利号ZL 2015 1 0930003.X,授权日期2018.06.12.
2. 褐孔菌内酯、其制法及其药物组合物与应用. 陈若芸,方莲花,刘超,杜冠华,康洁,武玉洁,王洪庆,李莉,孙岚,李保明. 专利号:ZL 201410132369.8,授权日期2019.01.01.

科技奖励

1. 2012, 桑属植物及其代谢产物的化学和生物活性基础研究,陈若芸、于德泉、申竹芳、谭永霞、张庆建、刘超、刘泉、戴胜军、杨燕、康洁、王洪庆、崔锡强、王磊、孙胜国、倪刚,北京市人民政府,北京市科学技术奖,一等奖.
2. 2012, 桑属植物及其代谢产物的化学和生物活性基础研究,陈若芸、于德泉、戴胜军、康洁、王洪庆、谭永霞、张庆建、崔锡强、王磊、倪钢、孙胜国,中华人民共和国教育部,高等学校科学研究优秀成果奖(科学技术),自然科学二等奖.