ZHU Ping
Principal Investigator
Professor Zhu is a doctoral supervisor at PUMC, head of Department of Biosynthesis of Natural Products, director of NHC Key Laboratory of Biosynthesis of Natural Products, deputy director of State Key Laboratory of Biosynthesis of Natural Products, vice president of Mycological Society of China, and editors of ACTA Pharmaceutica Sinica and Mycosystema. Currently his research interest includes: 1) Biosynthetic gene mining and catalytic enzyme characterization of natural medicines, elucidation and reconstruction of biosynthetic pathway in microbial system. 2) Discovery, production and new drug R&D of active compounds produced by medicinal fungi, etc.
Some achievements have been published in top international journals like Nature Communications, Green Chemistry, Acta Pharmaceutica Sinica B and Fungal Diversity. Dozens of patents have been authorized at home and abroad. He obtained the third award of Science & Technology of Chinese Pharmaceutical Association in 2011 and was awarded the title of outstanding teacher of PUMC in 2020. One PhD graduate won the award of excellent doctoral degree dissertation of PUMC in 2018, and the other was awarded the title of outstanding graduate of universities in Beijing in 2019. He and his co-workers discovered AMPK agonistic function of 3′-deoxyadenosine, which was used to develop a novel hypolipidemic drug.
1. Construction of acetyl-CoA and DBAT hybrid metabolic pathway for acetylation of 10- deacetylbaccatin III to baccatin III. Acta Pharmaceutica Sinica B , 2021, https://doi.org/10.1016/j.apsb.2021.03.029
2. De novo transcriptome sequencing of Rhododendron molle and identification of genes involved in the biosynthesis of secondary metabolites. BMC Plant Biology , 2020, 20(1), 414.
3. Structures of β-glycosidase LXYL-P1-2 reveals the product binding state of GH3 family and a specific pocket for Taxol recognition. Communications Biology , 2020, 3(1), 22.
4. High-level soluble expression of human Cu, Zn superoxide dismutase with high activity in Escherichia coli. World Journal of Microbiology and Biotechmology , 2020, 36, 106.
5. Construction and optimization of microbial cell factories for the sustainable production of bioactive dammarenediol-II glucosides. Green Chemistry , 2019, 219(12): 3286-3299.
6. Fed-batch high-cell-density fermentation strategies for Pichia pastoris growth and production. Critical Reviews in Biotechnology , 2019, 39(2): 258-271.
7. Combinatorial mutation on the β -glycosidase specific to 7- β -xylosyltaxanes and increasing the mutated enzyme production by engineering the recombinant yeast. Acta Pharmaceutica Sinica B , 2019, 9(3):626-638.
8. Advances in targeting and heterologous expression of genes involved in the synthesis of fungal secondary metabolites. RSC Advances , 2019, 9, 35124–35134.
9. Epigenetic modification enhances ergot alkaloid production of Claviceps purpurea. Biotechnology Letters, 2019, 41,1439–1449.
10. Site-directed mutagenesis of bata-Glycoside hydrolase from lentinula edodes. Molecules , 2019, 24, 59.
11. Tetrocarcin Q, a new spirotetronate with a unique glycosyl group from a marine-derived actinomycete Micromonospora carbonacea LS276. Marine Drugs , 2018, 16, 74.
12. Chrysoxanthones A–C, three new xanthone–chromanone heterdimers from sponge-associated Penicillium chrysogenum HLS111 treated with histone deacetylase inhibitor. Marine Drugs , 2018, 16, 357.
13. Improving 10-deacetylbaccatin III-10-β-Oacetyltransferase catalytic fitness for Taxol production. Nature Communication , 2017, 8, 15544.
14. Cloning and characterization of the glycoside hydrolases that remove xylosyl group from 7-β-xylosyl-10-deacetyltaxol and its analogues. Molecular & Cellular Proteomics , 2013, 12(8):2236-2248. (Cover Image and Highlight from this Issue)
15. Phylogenetic diversity of culturable fungi associated with two marine sponges: Haliclona simulans and Gelliodes carnosa , collected from the Hainan Island coastal waters of the South China Sea. Fungal Diversity , 2010, 42:1-15.
1. Exploring alternative Taxol sources: biocatalysis of 7-β-xylosyl-10-deacetyltaxol and application for Taxol production. In: Pharmaceutical Biocatalysis. Wan-Cang Liu, Bing-Juan Li, Ting Gong, Ping Zhu. Edited by Peter Grunwald. Pan Stanford Publishing Pte Ltd. Jenny Stanford Publishing. Chapter 2. ISBN 9789814877145. Published November 25, 2020.
2. Demonstration-scale high-cell-density fermentation of Pichia pastoris. In: Recombinant Glycoprotein Production: Methods and Protocols, Methods in Molecular Biology. Wan-Cang Liu, Ping Zhu. Edited by Virgínia Picanco-Castro and Kamilla Swiech. Springer Science+Business Media LLC 2018. vol.1674.
3. Medicinal Fungal Research in China. In: McGraw-Hill Year Book of Science & Technology 2011. Ping Zhu and Hua-An Wen. Edited by David Blumel, et al. The McGraw-Hill Companies, Inc. 2011. pp.188-191.
4. Biotechnological Studies on Anisodus tanguticus . In: Recent Pregress in Medicinal Plants. Volume 16 Phytomedicines. Kedi Cheng, Tao Liu, Cao Meng and Ping Zhu. Edited by Govil JN, Singh VK and Bhardwaj R. Studium Press LLC, USA. 2006, pp.9-32.
2011, The third prize. Awards of Scienence & Technology of Chinese Pharmaceutical Association.
