ZHENG Wensheng
Principal Investigator
From 1998 to the present, Zheng Wensheng has been working at Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, as a professor, project leader, and doctoral supervisor. Professor Zheng has undertaken 11 research projects on key technology and standards, and dozens of enterprise cooperation projects. He has published more than 110 papers, and obtained 8 clinical approvals, 9 new drug certificates and 8 national invention patents.
1. Borneol-mediated vardenafil hydrochloride patch for pediatric pulmonary arterial hypertension:.Preparation, characterization and in vivo studyInternational. Journal of Pharmaceutics, 2020 https://doi.org/10.1016/j.ijpham.2020.119864.
2. A novel α-(8-quinolinyloxy) monosubstituted zinc phthalocyanine nanosuspension for potential enhanced photodynamic therapy. Drug Development and Industrial Pharmacy，2020, 46(11), 1881-1888；
3. Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases. Nature communication , 2019, 10:1981/https://doi.org/10.1038/s41467-019-09852-0.
4. Dual-Stimuli-Responsive Gut Microbiota-Targeting Berberine-CS/PT-NPs Improved Metabolic Status in Obese Hamsters. Advanced functional materials , 2019, 1808197.
5. Enhanced transdermal permeability and drug deposition of rheumatoid arthritis via sinomenine hydrochloride-loaded antioxidant surface transethosome. International Journal of Nanomedicine, 2019, 14: 3177-3188.
6. A novel dantrolene sodium mixed micelle containing a reduced amount of cremophor EL: characterization, stability, safety and pharmacokinetics Preparation and evaluation of dantrolene sodium loaded mixed micelle for intravenous administration. Molecules，2019, 24, 728; doi:10.3390/molecules24040728.
7. Design, characterization and comparison of transdermal delivery of colchicine via borneol-chemically-modified and borneol-physically-modified ethosome. Drug Delivery , 2019, 26(1):70-77.
8. Enhanced permeability of blood brain barrier and targeting function of brain via borneol-modified chemically solid lipid nanoparticle (BO-SLN/CM). International Journal of Nanomedicine, 2018, 13: 1869-1879.
9. Self-assembling HA/PEI/dsRNA-p21 ternarycomplexes for CD44 mediated small active RNA delivery to colorectal cancer. Drug Delivery , 2017,24(1):1537-1548. https://doi.org/10.1080/10717544.2017.1386732.
10. Tumor-selective lipopolyplex encapsulated small active RNA hamperscolorectal cancer growth in vitro and in orthotopic murine. Biomaterials , 2017, 141:13-28.
2018, Xinzheng Science and Technology Progress Award, third prize, China.
