ZHAO Zhehui
In July 2014, Zhao Zhehui got his PhD degree in medicinal chemistry from the Institute of Materia Medica, Chinese Academy of Medical Science, under the supervision of Professor Lei. In recent years his research group has been engaged in the synthesis of highly active molecules containing saccharide and the study of their structure-activity relationships, such as macrolide antibiotics, OSW-1, and chondroitin sulfate oligosaccharides. Up to now, a total of 13 papers have been published.
1. Synthesis and Antibacterial Activity of Novel 4′′- O -desosaminyl clarithromycin derivatives with 11, 12-arylalkyl side chains. JANPR, 2019, 7, 610-618.
2. Antibacterial activities of a series of novel 5- O -(4′, 6′- O -dimodified)-mycaminose 14-membered ketolides. JANPR, 2019, 5, 456–461.
3. An efficient and facile approach for construction of chondroitin sulfate E oligosaccharides precursors. CCL, 2019, 30, 686–689.
4. Synthesis of novel 5- O -(6′- O -modified)-desosamine 14-membered ketolides. CCL, 2019, 30, 425–427.
5. The synthesis and biological evaluation of chondroitin sulfate E glycodendrimers. Future Med. Chem. 2019, 11(12), 1403–1415.
6. Two novel N-glycoside 17, 18-unsaturated acid quinolin-3-ylmethyl ester josamycin derivatives. TL, 2018, 59, 1208-1211.
7. Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains. BMCL, 2018, 14, 2358-2363.
8. An Approach to Synthesize Chondroitin Sulfate-E (CS–E) Oligosaccharides Precursors. JOC, 2018 83, 5897-5908.
9. Synthesis and antibacterial activities of some novel 17, 18-unsaturated carbonyl compounds derivated from josamycin. JANPR, 2017, 4, 358-387.
10. An investigation of construction of chondroitin sulfate E (CS-E) repeating unit. Tetrahedron, 2016, 72, 5659-5670.
11. Synthesis, conformational analysis and SAR research of OSW-1 Analogues. Tetrahedron, 2016, 72, 4091-4102.
12. An efficient method to synthesize novel 5-O-(6’-modified)-mycaminose 14-membered ketolide. Tetrahedron, 2016, 72, 285-297.
