ZHANG Xiaowei
Prof. Zhang received his PhD degree in pharmacology from Peking Union Medical College (PUMC) in 2009, with his research interest in cardiovascular immunopharmacology. After then, he joined University of Cincinnati School of Medicine in the United States for a four-year postdoctoral research, during which he was awarded the Postdoctoral fellowship by the American Heart Association and the title of Outstanding Young Scientist by the University of Cincinnati Cardiovascular Center. Since returning to China in 2013, his relevant research work has been supported by a number of funds, and has published more than 40 academic papers with total impact factor of over 240. As the first/corresponding author, he has published more than 10 papers in a series of international journals such as Circulation , Autophagy , Acta Parm Sin B , and J Am Heart Assoc . He has also been awarded the title of "Union New Star" by Chinese Academy of Medical Sciences and the 18th SERVIER Young Pharmacologist by Chinese Pharmacological Society. Prof. Zhang’s major research interests focus on: 1) The pathogenesis investigation and drug development of cardiovascular and liver fibrosis. 2) Protein quality control especially cell autophagy mediated cell biology mechanism in the process of tissue fibrosis. 3) Research and development of new polypeptide and natural products active molecules targeting protein-protein interaction.
1. Klionsky DJ*, Cui B, Hua F, Li K, Zhang XW, Hu ZW, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy , DOI: 10.1080/15548627.2020.1797280, 2021
2. Xu AJ, Zhou JC, Li YM, Qiao LY, Jin CC, Chen W, Sun L, Wu SN, Li XJ, Zhou DH, Jia SY, Zhang B, Yao JY, Zhang XW*, You H*, Huang J*. 14-kDa Phosphohistidine Phosphatase is a Potential Therapeutic Target for Liver Fibrosis. Am J Physiol Gastrointest Liver Physiol , 320(3):351-365, 2021 (* co-corresponding author)
3. Zhang XW, Zhou JC, Peng D, Hua F, Li K, Yu JJ, Lv XX, Cui B, Liu SS, Yu JM, Wang F, Jin CC, Yang ZN, Zhao CX, Hou XY, Huang B, Hu ZW*. Disrupting the TRIB3-SQSTM1 interaction reduces liver fibrosis by restoring autophagy and suppressing exosome-mediated HSC activation. Autophagy , 16(5):782-796, 2020
4. Liu P, Bao HY, Jin CC, Zhou JC, Hua F, Li K, Lv XX, Cui B, Hu ZW, Zhang XW*. Targeting Extracellular Heat Shock Protein 70 Ameliorates Doxorubicin-Induced Heart Failure Through Resolution of Toll-Like Receptor 2-Mediated Myocardial Inflammation. J Am Heart Assoc , 8(20):e012338, 2019
5. Zhang XW, Sun L, Chen W, Wu SN, Li YM, Li XJ, Zhang B, Yao JY, Wang H, Xu AJ*. ARHGEF4-mediates the actin cytoskeleton reorganization of hepatic stellate cells in 3-dimensional collagen matrices. Cell Adh Migr , 13(1):169-181, 2019
6. Zhou JC, Zhang XW*. Akkermansia muciniphila : a promising target for the therapy of metabolic syndrome and related diseases. Chin J Nat Med , 17(11): 835-841, 2019
7. Jin W, Cui B, Li PP, Hua F, Lv XX, Zhou JC, Hu ZW, Zhang XW*. 1,25- Dihydroxyvitamin D3 protects obese rats from metabolic syndrome via promoting regulatory T cell-mediated resolution of inflammation. Acta Pharm Sin B , 8(2):178-187, 2018
8. Wu RN, Yu TY, Zhou JC, Li M, Gao HK, Zhao C, Dong RQ, Peng D, Hu ZW, Zhang XW*, Wu YQ*. Targeting HMGB1 ameliorates cardiac fibrosis through restoring TLR2-mediated autophagy suppression in myocardial fibroblasts. Int J Cardiol , 267:156-162, 2018 (* co-corresponding author)
9. Zhang XW, Mi S, Li Z, Zhou JC, Xie J, Hua F, Li K, Cui B, Lv XX, Yu JJ, Hu ZW*. Antagonism of Interleukin-17A ameliorates experimental hepatic fibrosis by restoring the IL-10/STAT3-suppressed autophagy in hepatocytes. Oncotarget , 8(6):9922-9934, 2017
10. Zhang XW, Zhou JC, Hu ZW*. Autophagy as a target for development of anti-diabetes drugs derived from natural compounds. J Asian Nat Prod Res , 19(4):314-319, 2017
11. Zhang XW, Wang XH, Zhu HY, Kranias EG, Tang YL, Peng TQ, Chang J, Fan GC*. Hsp20 functions as a novel cardiokine in promoting angiogenesis via activation of VEGFR2. PLoS One , 7(3):e32765, 2012
12. Ma YG†, Zhang XW†, Bao HY, Mi S, Cai WF, Yan HM, Wang QQ, Wang ZY, Yan J, Fan GC, Lindsey ML, Hu ZW*. Toll-like receptor (TLR) 2 and TLR4 differentially regulate doxorubicin induced cardiomyopathy in mice. PLoS One , 7(7):e40763, 2012 († co-first author)
13. Wang XH†, Zhang XW†, Ren XP, Chen J, Liu HZ, Yang JQ, Medvedovic M, Hu ZW, Fan GC*. MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/ reperfusion-induced cardiac injury. Circulation , 122(13):1308-18, 2010 († co-first author)
14. Zhang XW, Wang XH, Zhu HY, Zhu C, Wang YG, Pu WT, Jegga AG, Fan GC*. Synergistic effects of the GATA4- mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death. J Mol Cell Cardiol , 49(5):841-50, 2010
15. Cai WF†, Zhang XW†, Yan HM, Ma YG, Wang XX, Yan J, Xin BM, Lv XX, Wang QQ, Wang ZY, Yang HZ, Hu ZW*. Intracellular or extracellular heat shock protein 70 differentially regulates cardiac remodelling in pressure overload mice. Cardiovasc Res , 88(1):140-9, 2010 († co-first author)
16. Qiao LY, Zhang XW*. Mechanism of "aberrant liver regeneration" and its role intreatment of liver fibrosis. Acta Pharmaceutica Sinica , 55(10): 2243-2255, 2020
17. Jin CC, Zhang XW*. Research progress of natural medicines and bioactive compounds against heart failure. Acta Pharm Sin , 55(6): 1147-1156, 2020
18. Peng D, Hu ZW, Zhang XW*. Therapeutic perspectives of intestinal probiotics A. muciniphila in metabolic disorders. Acta Pharm Sin , 54(5): 768-777, 2019
19. Zhang XW, Cai WF, Hu ZW*. Advances in the study of immunopathological mechanism of dilated cardiomyopathy. Advances in Cardiovascular Diseases , 30(5):814-817, 2009
20. Li K, Zhang TT, Zhao CX, Wang F, Cui B, Yang ZN, Lv XX, Yeerjiang Z, Yuan YF, Yu JM, Wang ZH, Zhang XW, Yu JJ, Liu SS, Shang S, Huang B, Hua F, Hu ZW. Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability. Sci Transl Med , 13(586): eabb2914, 2021
21. Li K, Wang F, Yang ZN, Zhang TT, Yuan YF, Zhao CX, Yeerjiang Z, Cui B, Hua F, Lv XX, Zhang XW, Yu JJ, Liu SS, Yu JM, Shang S, Xiao Y, Hu ZW*. TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation. Nat Commun , 11(1): 6316, 2020
22. Yu JJ, Zhou DD, Yang XX, Cui B, Tan FW, Wang JJ, Li Ke, Shang S, Zhang C, Lv XX, Zhang XW, Liu SS, Yu JM, Wang F, Huang B, Hua F*, Hu, ZW*. TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target, Nat Commun, 11(1): 3660, 2020
23. Yu JM, Sun W, Wang ZH, Liang X, Hua F, Li K, Lv XX, Zhang XW, Liu YY, Yu JJ, Liu SS, Shang S, Wang F, Yang ZN, Zhao CX, Hou XY, Li PP, Huang B, Cui B*, Hu ZW*. TRIB3 Supports Breast Cancer Stemness by Suppressing FOXO1 Degradation and Enhancing SOX2 Transcription. Nat Commun. 10(1):5720, 2019
24. Liu SS, Lv XX, Liu C, Qi J, Li YX, Wei XP, Li K, Hua F, Cui B, Zhang XW, Yu JJ, Yu JM, Wang F, Shang S, Zhao CX, Hou XY, Yao ZG, Li PP, Li X, Huang B, Hu ZW*. Targeting Degradation of the Transcription Factor C/EBPβ Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages. Immunity , 51(3):522-534.e7, 2019
25. Hua F, Shang S, Yang YW, Zhang HZ, Xu TL, Yu JJ, Zhou DD, Cui B, Li K, Lv XX, Zhang XW, Liu SS, Yu JM, Wang F, Zhang C, Huang B, Hu ZW*. TRIB3 Interacts with β-Catenin and TCF4 to Increase Stem Cell Features of Colorectal Cancer Stem Cells and Tumorigenesis. Gastroenterology , 156(3):708-721, 2019
26. Li K, Zhang TT, Wang F, Cui B, Zhao CX, Yu JJ, Lv XX, Zhang XW, Yang ZN, Huang B, Li X, Hua F, Hu ZW. Metformin suppresses melanoma progression by inhibiting KAT5-mediated SMAD3 acetylation, transcriptional activity and TRIB3 expression. Oncogene , 37(22):2967-2981, 2018
27. Li K, Wang F, Cao WB, Lv XX, Hua F, Cui B, Yu JJ, Zhang XW, Shang S, Liu SS, Yu JM, Han MZ, Huang B, Zhang TT, Li X, Jiang JD, Hu ZW*. TRIB3 Promotes APL Progression through Stabilization of the Oncoprotein PML-RARα and Inhibition of p53-Mediated Senescence. Cancer Cell , 31(5):697-710, 2017
28. Hua F, Li K, Yu JJ, Lv XX, Yan J, Zhang XW, Sun W, Lin H, Shang S, Wang F, Cui B, Mu R, Huang B, Jiang JD, Hu ZW*. TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations. Nat Commun , 6:7951, 2015
29. Yan HM, Cui Bing, Zhang XW, Fu XM, Yan J, Wang XX, Lv XX, Chen Z, Hu ZW*. Antagonism of toll-like receptor 2 attenuates the formation and progression of abdominal aortic aneurysm. Acta Pharm Sin B , 45(3):176-187, 2015
1. Autophagic Flux Detection: Significance and Methods Involved. Autophagy-Biology and Disease-Technical Volume (3rd Edition). Lv XX, Zhang XW, Zhou JC, Qiao LY, Jin CC, Hu ZW. Edited by Xie Zhi-Ping. Science Press , Print ISBN: 978-7-03-068383-0
2. Regulating cardiac remodeling and myocardial regeneration for chronic cardiovascular disease. Practical Molecular Pharmacology (2nd Edition). Hu ZW, Zhang XW. Edited by Wang Xiao-Liang. Peking Union Medical College Press , Print ISBN: 978-7-5679-0411-8
3. Molecular mechanisms of vascular and blood pressure regulation and drug application. Practical Molecular Pharmacology (2nd Edition). Zhang XW, Hu ZW. Edited by Wang Xiao-Liang. Peking Union Medical College Press , Print ISBN: 978-7-5679-0411-8
4. Autophagic Flux Detection: Significance and Methods Involved. Autophagy-Biology and Disease (2nd Edition). Lv XX, Zhang XW, Hu ZW. Edited by Qin Zheng-Hong. Science Press , Print ISBN: 978-7-03-044498-1
5. Methods and techniques for cutaneous fibrosis. Modern Experimental Methods of Pharmacology (2nd Edition). Zhang XW, Yan J, Hu ZW. Edited by Zhang Jun-Tian & Du Guan-Hua. Peking Union Medical College Press , Print ISBN: 978-7-81136-375-3/R.375
6. Important fibrotic promoting factors and anti-fibrotic factors. Fundamentals of Organ Fibrosis and its Prevention and Treatment by Traditional Chinese Medicine. Zhang XW, Yang HZ, Ben CE. Edited by Niu Jian-Zhao & Ben Chang-En. People's Medical Publishing House , Print ISBN: 978-7-117-09337-8/R.9338
1. 2017, Mechanism and drug target discovery of the involvement of abnormal immune-autophagy regulation in fibrosis and tumor pathogenesis. Hu ZW, Hua F, Zhang XW, Lv XX, Lin H, Cui B, Li K. Natural Science Awards from the Ministry of Education, Second prize, China
2. 2017, TLRs-mediated immune-autophagy regulation of fibrosis and tumor development mechanism and drug target discovery. Hu ZW, Hua F, Zhang XW, Lv XX, Lin H, Wang ZY, Lv Q, Yang HZ. China Medical Science and Technology Award. Third prize, China
3. 2016, TLRs-mediated immune-autophagy regulation of fibrosis and tumor development mechanism and drug target discovery. Hu ZW, Hua F, Lin H, Zhang XW, Lv XX, Wang ZY. Beijing Science and Technology Award. Third prize, China
