ZHANG Xiang
Zhang Xiang is working as an associate professor and MS supervisor with the Institute of Materia Medica, Chinese Academy of Medical Sciences. He is a licensed pharmacist. He has more than 20 years of research experience in the field of drug R&D. During his career, he has presided over a number of the R&D and industrial technology transfer projects of innovative drugs and high-end generic drugs. As a sub project leader, he has completed preclinical study of a new drug for drug-resistant tuberculosis. He has published more than 20 research papers and filed more than 10 patents. His research interests focus on medicinal chemistry, including (i) development of innovative drugs; (ii) chiral drug's synthesis methodology; (iii) the process study of drugs with complex structures.
1. An Eco-Friendly Industrial Fischer Indole Cyclization Process. Organic Process Research & Development ; 2018, 22, 1115-1118.
2. In situ intramolecular difluorocarbene-triggered synthesis of 2-gem-difluoro-2,3-dihydrobenzofuran-3-ols. Tetrahedron Letters ; 2018, 59: 2941-2944.
3. A high-performance liquid chromatography-electronic circular dichroism online method for assessing the absolute enantiomeric excess and conversion ratio of asymmetric reactions. Scientific Reports ; 2017, 7:43278. DOI: 10.1038/srep43278.
4. A Morphological identification cell cytotoxicity assay using cytoplasmlocalized fluorescent probe (CLFP) to distinguish living and dead cells. Biochemical and Biophysical Research Communications ; 2017, 482 (2): 257-263.
5.Structural Simplification of Bedaquiline: the Discovery of 3-(4-(N,N-Dimethylaminomethyl)phenyl)quinoline-Derived Antitubercular Lead Compounds. ChemMedChem ; 2017, 12 (2): 106-119.
6. A high-resolution method to assess cell multinucleation with cytoplasm-localized fluorescent probes. Analyst ; 2016, 141: 4010-4013.
7. Development of a validated LC–APCI-MS/MS method to study the plasma and tumor distribution of CHO-PTX intravenous lipid emulsion. J Pharmaceutical and Biomedical Analysis ; 2016, 117: 532-543.
8. A facile and efficient synthesis of 4 H -1,3-benzoxazine-4-one with electron-withdrawing group derivatives. Tetrahedron Letters ; 2015, 56: 4683-4685.
9. Synthesis and bio-evaluation of phenothiazine derivatives as new antituberculosis agents. Chinese Chemical Letters ; 2015, 26 (2015): 951-954.
10. Development of 3-alkyl-6-methoxy-7-hydroxychromones (AMHCs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging. Chem. Commun., 2015, 51:881-884.
