ZHANG Wenxuan
Zhang Wenxuan graduated from Peking University with a doctoral degree in 2013. He is currently the Deputy Director, Associate Researcher, Postgraduate Tutor of Department of New Drug Research and Development, Institute of Materia Medica, Chinese Academy of Medical Sciences. In terms of innovative drug research and development, as the main contributor, he developed two original drug candidates for blood lipid regulation and for the treatment of non-alcoholic hepatitis (NASH) respectively, and anti-drug resistant preclinical bacteria pharmacy research and development work of infection original drug candidates and other varieties. He has conducted and participated in multiple national grant studies. He has published more than 30 papers in domestic and foreign journals such as Nat Commun., Eur. J. Med. Chem, etc., applied for more than ten patents, and served as reviewer for Eur. J. Med. Chem. and other medicinal chemistry journals.
1. Metallaphotoredox -catalyzed C–H activation: regio-selective annulation of allenes with benzamide. Org Chem Front, 2021, 8(5): 928-935.
2. Quantitative 1H nuclear magnetic resonance method for assessing the purity of dipotassium glycyrrhizinate. Molecules, 2021, 26(12): 3549.
3. The structure optimization of dicarboximide-phenylpyridine conjugates as inhibitor of Wnt signaling Pathway. Chemistry select, 2020, 5: 13795 – 13799
4. Amide-sialoside protein conjugates as neomucin bioshields prevent influenza virus infection. Carbohyd Res, 2020, 495: 108088.
5. Mangiferin Ameliorates Hyperuricemic Nephropathy Which Is Associated With Downregulation of AQP2 and Increased Urinary Uric Acid Excretion. Front Pharmacol, 2020, 11: 49.
6. Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases. Nat Commun., 2019, 10(1): 1981.
7. Discovery and structure-activity relationship study of phthalimide- phenylpyridine conjugate as inhibitor of Wnt pathway. Bioorg. Med. Chem. Lett., 2019, 29: 870-872.
8. A Useful Synthesis of 2-Acylamino-1,3,4-oxadiazoles from Acylthiosemicarbazides Using Potassium Iodate and the Discovery of New Antibacterial Compounds. Molecules, 2019, 24: 1490
9. Protective effects of a novel water-soluble biphenyl compound WLP-S-14 against acute-on-chronic liver failure in rats. J Asian Nat Prod Res, 2019, 21(9): 928-938.
10. Identification and Characterization of Two New 1‑O‑Acyl-glucoseester Forming Glucosyltransferases from Erigeron breviscapus. J. Agric. Food Chem., 2019, 67: 2848−2855.
11. A Concise Synthesis of (±)-7- O -Galloyltricetiflavan. RSC Adv., 2018, 8: 14389.
12. Design and synthesis of conformationally constrained salinomycin derivatives. Eur. J. Med. Chem., 2017, 138: 353.
13. A Novel Synthesis of 4-Acetoxyl 5(4H)-Oxazolones by Direct α-Oxidation of N-Benzoyl Amino-Acid Using Hypervalent Iodine. Molecules, 2017, 22: 1102.
14. Synthesis and biological activity of salinomycin-hydroxamic acid conjugates. Bioorg Med Chem Lett, 2017, 27: 1624.
15. Tumor-selective lipopolyplex encapsulated small active RNA hampers colorectal cancer growth in vitro and in orthotopic murine. Biomaterials, 2017, 141: 13-28
16. Synthesis and biological activity evaluation of 20-epi-salinomycin and its 20-O-acyl derivatives. RSC Adv. , 2016, 6: 41885.
17. Structure–activity & structure–toxicity relationship study of salinomycin diastereoisomers and their benzoylated derivatives. Org Biomol Chem, 2016, 14: 2840.
18. An attempt to construct the C/D ring system of parkacine by intramolecular cycloaddition of azomethine ylide and alkyne . Tetrahedron Lett ., 2016, 57: 1981.
19. The synthesis of the metabolites of 2′,3′,5′-Tri- O -acetyl- N6 -(3-hydroxyphenyl) adenosine (WS070117). Molecules , 2015, 21: 8.
20. Design, synthesis and antibacterial activities of conformationally constrained kanamycin A derivatives. J. Org. Chem., 2013, 78: 400−409.
21. Concise synthesis and antitumor activity of Bengamide E and its analogs. Tetrahedron, 2013, 69: 664-672.
